The Methodist Hospital Research Institute
Clinical trials sponsored by The Methodist Hospital Research Institute, explained in plain language.
Upcoming readouts
Trials from this sponsor expected to report results within the next 12 months.
- Can a simple nasal dilator quiet the ear symptoms of patulous eustachian tube? Results expected Nov 2026 (estimated)
- New combo therapy aims to boost prostate cancer fight before surgery Results expected Nov 2026 (estimated)
- New cocktail targets rare breast cancer that defies standard treatment Results expected Dec 2026 (estimated)
- Could a peptide supercharge COVID-19 vaccines for seniors? Results expected Dec 2026 (estimated)
- Can a steroid blast calm kidney stent pain? Results expected Dec 2026 (estimated)
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Can a smart immune cell with a kill switch beat tough lymphomas?
Cure Not yet recruitingThis Phase 1 trial tests a new type of cell therapy for people with relapsed or refractory CD30-positive lymphomas, including Hodgkin lymphoma and certain non-Hodgkin lymphomas. The treatment uses a patient's own immune cells that are genetically engineered to recognize and attac…
Phase 1 • Sponsor: The Methodist Hospital Research Institute • Aim: Cure
Last updated Jul 29, 2026 00:00 UTC
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Can a Weight-Loss drug and an IUD treat early uterine cancer without surgery?
Disease control Not yet recruitingResearchers are testing whether a combination of semaglutide (Wegovy), a levonorgestrel-releasing intrauterine device (LNG-IUD), and a structured weight loss program can treat endometrial atypical hyperplasia or early-stage, grade 1 endometrioid endometrial cancer in women who wa…
Phase 2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Botox before the scalpel: a new angle on High-Risk prostate cancer
Disease control Not yet recruitingThis pilot study tests whether injecting Botox into the prostate a few weeks before surgery can improve outcomes for men with high-risk localized prostate cancer. Thirty men will receive either a single Botox injection or a placebo, then undergo standard prostate removal surgery.…
Phase 1/2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Can a RAGE inhibitor revive a failing breast cancer treatment?
Disease control Not yet recruitingThis trial is testing whether adding azeliragon, a RAGE inhibitor, to the drug T-DXd can help people with HER2-positive or HER2-low metastatic breast cancer whose cancer has progressed despite prior T-DXd treatment. The study will first find the safest dose of the combination, th…
Phase 1/2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Laser vs. water jet: which surgery for enlarged prostate is better?
Disease control Not yet recruitingThis trial compares two FDA-approved surgeries for benign prostatic hyperplasia (BPH), a condition where the prostate enlarges and causes urinary problems. Men aged 50-80 with moderate-to-severe symptoms and prostate sizes between 50 and 180 mL will be randomly assigned to receiv…
Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Bone injection may beat IV for spine surgery infections
Disease control Not yet recruitingThis study compares two ways of giving the antibiotic vancomycin during lumbar fusion surgery: injecting it directly into the bone marrow versus the standard method through a vein. Researchers want to see which method delivers higher antibiotic levels to the bone and soft tissue,…
Phase 2/3 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New blood test could personalize AML treatment
Diagnosis Not yet recruitingThis study tests a new blood test (5hmC) to see if it can help doctors choose between two standard treatments for acute myeloid leukemia (AML): a milder drug (hypomethylating agent) or strong chemotherapy. About 112 newly diagnosed adults will have their blood tested after initia…
Phase 2 • Sponsor: The Methodist Hospital Research Institute • Aim: Diagnosis
Last updated Jun 27, 2026 09:11 UTC
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Bone injection may boost antibiotic power in knee surgery
Knowledge-focused Not yet recruitingThis study tests whether giving the antibiotic vancomycin directly into the bone (via the ankle) works better than the usual IV method during revision knee replacement surgery. Forty adults having a second knee replacement will be randomly assigned to one of the two methods. Rese…
Sponsor: The Methodist Hospital Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC