The Methodist Hospital Research Institute

This study tests whether giving the drug atezolizumab before surgery is safe for people with high-risk melanoma that hasn't spread. About 20 participants will receive two doses before their operation. The goal is to see if this approach can help control the disease and reduce the…

This study tests whether adding the immunotherapy drug durvalumab to two standard targeted drugs (trastuzumab and pertuzumab) can shrink tumors more effectively in people with a specific, aggressive type of breast cancer called HER2-enriched. About 51 women with this cancer will …

This study tests a new approach for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. It combines an immunotherapy drug (sasanlimab) with targeted radiation to boost the immune system's ability to fight the tumor before surgical removal of the b…

This early-stage trial tests the safety of combining two drugs, olaparib and vorinostat, in people with advanced breast cancer that has returned or spread. The study includes 28 adults whose cancer is not HER2-positive. The goal is to find the best dose and check for side effects…

This study tests whether adding the drug belumosudil to standard anti-rejection medicines can prevent scarring in new kidney transplants. Scarring often leads to transplant failure over time. About 40 adults receiving a first or second kidney will take either the drug or a placeb…

This study tests whether using a lower, personalized tourniquet pressure during orthopedic surgeries can reduce post-operative pain and the need for opioid painkillers. Researchers will enroll 400 adults undergoing common procedures like knee replacement or carpal tunnel release.…

This study tests whether adding blood flow restriction (BFR) therapy to standard physical therapy helps people regain strength and muscle mass after wrist fracture surgery. About 70 adults who had surgery for a broken wrist will either get standard rehab or standard rehab plus BF…

This study looks at two methods of giving the antibiotic vancomycin during shoulder replacement surgery: standard IV (into a vein) versus intraosseous (into the bone). Researchers want to see if both methods deliver similar levels of the drug to bone and tissue. About 33 adults h…