Samsung Medical Center

This phase II trial tests whether the immunotherapy drug avelumab can keep upper tract urothelial carcinoma from coming back after standard cisplatin-based chemotherapy. About 48 adults with high-risk muscle-invasive or node-positive disease who have completed chemotherapy withou…

This phase 2 trial tests whether adding a special type of radiation called adaptive pulse radiotherapy to standard immunotherapy can help treat advanced solid tumors. The study will enroll 35 people with various cancers who are already receiving or planning to receive immune chec…

This study tests a drug called selinexor combined with chemotherapy in 37 adults with B-cell lymphoma that has come back or not responded to treatment and has spread to the brain. The goal is to find the safest dose and see if the combination can shrink tumors. Selinexor works by…

This phase 3 trial compares two types of radiation therapy for men whose prostate cancer has returned after surgery. One schedule takes 5-6 weeks, while the other is completed in just 2 weeks. The study aims to see if the shorter option works just as well with manageable side eff…

This study looks at whether quickly restoring normal heart rhythm (early rhythm control) can help people who have both atrial fibrillation (an irregular heartbeat) and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to either earl…

This study tests a shorter, more intense radiation schedule combined with chemotherapy for cervical cancer. Standard treatment takes 7-8 weeks, but this approach aims to finish in less time while still controlling the tumor. The trial includes 34 adults with advanced cervical can…

This study compares two types of anesthesia—propofol-based intravenous anesthesia versus inhaled gas anesthesia—in over 5,300 people having surgery for early-stage non-small cell lung cancer. The goal is to see if one method leads to a longer time before the cancer comes back. Pa…

This phase 2 trial tests whether combining two targeted drugs—lazertinib and tepotinib—can shrink tumors in people with advanced EGFR-mutant non-small cell lung cancer whose disease has worsened after initial lazertinib treatment due to MET gene changes. About 47 participants wil…

This study tests whether a stronger blood thinner (prasugrel) combined with aspirin works better than the standard combo (clopidogrel plus aspirin) in heart disease patients undergoing complex artery stenting. About 3,500 adults will be enrolled to see if the stronger combo reduc…

This study tests a new way to deliver radiation for pancreatic cancer, called PULSAR, combined with proton therapy. It involves giving short, high-dose radiation pulses every few weeks, which may be safer and more effective than standard radiation. The trial enrolls about 47 adul…

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) in the lungs from growing after surgery for a specific type of lung cancer. About 43 adults with early-stage lung cancer and an EGFR mutation will take a daily pill for one year. The goal is to…

This study looks at 408 adults with severe heart shock who need a heart-lung machine (ECMO) and have kidney injury. It compares starting kidney dialysis early versus waiting for standard timing. The goal is to see which approach reduces death or the need for long-term dialysis.

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see which approach leads …

This study compares a newer pacing method (left bundle branch area pacing) to the standard method (right ventricular pacing) in 200 people with heart block and normal heart function. The goal is to see if the newer method better preserves heart pumping ability and reduces complic…

This study looks at whether people with a high risk of bleeding who have stable coronary artery disease can safely stop taking antiplatelet medication (blood thinners) after a drug-coated balloon angioplasty. Participants must have been on standard blood thinners for at least a y…

This study tests whether the drug osimertinib can stop or shrink small, hazy lung spots (called ground-glass nodules) that remain after surgery for a type of lung cancer. About 59 adults with EGFR-mutant lung adenocarcinoma will take one pill daily. The goal is to see if the drug…

This study looks at 2,000 people with chest pain and moderate coronary artery blockages seen on a CT scan. It compares an invasive approach (like stenting or bypass) with a non-invasive approach (medication and lifestyle changes) to see which leads to fewer heart attacks, deaths,…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can help control the condition. About 520 adults with these hidden AF episodes will be randomly assigned to either early rhythm control therapy (medication, sh…

This study compares two procedures for removing small precancerous growths in the stomach. One method cuts out the growth, while the other uses a gas-based tool to burn it away. Researchers want to see if the simpler gas method works just as well and causes fewer side effects. Ab…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This study looks at whether a small, wearable continuous glucose monitor (CGM) can accurately diagnose dumping syndrome in people who have had surgery for esophageal cancer. Dumping syndrome happens when food moves too quickly into the small intestine, causing symptoms like dizzi…

This study tests whether a smart board device can help people with arm weakness from brain disorders (like stroke or brain injury) do rehab at home. Forty adults will either use the smart board or a workbook for 4 weeks. The goal is to see if the smart board improves arm function…

This study tests whether adjusting a pacemaker to a personalized, optimal heart rate can improve symptoms and quality of life in people with heart failure and a slow heartbeat. About 106 adults with heart failure who need a permanent pacemaker will be randomly assigned to either …

This study tests a smartphone app that provides personalized exercise and education to people recovering from rotator cuff repair surgery. The goal is to see if the app improves shoulder function and reduces pain better than standard care. About 70 adults who have had this surger…

This study tests a personalized approach to brain stimulation (rTMS) for people with Parkinson's disease. The goal is to see if tailoring the stimulation to each patient's brain function improves walking better than the standard one-size-fits-all method. The study will involve 60…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

The HOPE study is a long-term research project at Samsung Medical Center that will collect medical information and tissue/blood samples from 350 head and neck cancer patients each year. The goal is to identify biomarkers that can predict how patients will respond to treatments li…

This study is developing and testing a new way to set recovery goals for children in the pediatric intensive care unit (PICU). The method, based on the Canadian Occupational Performance Measure (COPM), focuses on what matters most to the child and their family. Researchers will f…

This study is collecting data from 2,200 children aged 0 to 12 who come to emergency rooms with breathing problems. Researchers will use videos and clinical information to train an artificial intelligence system to automatically recognize different breathing patterns. The goal is…

This study looks at whether a follow-up CT scan of the heart's arteries, done one year after stent placement, can reduce the risk of heart attacks, death, or other major heart problems compared to usual care. It will include 3,500 high-risk patients who have had a stent placed. T…

This study is analyzing blood and tumor samples from 30 people with advanced head and neck cancer who are receiving standard immunotherapy plus chemotherapy. The goal is to find biological markers that can predict who will respond well to treatment. By understanding changes in th…

This study aims to find genetic markers in blood and tissue that can help doctors better diagnose early stomach cancer and precancerous growths, and predict if the cancer will come back after treatment. Researchers will collect samples from 1,730 adults with these conditions and …

This study follows 300 Korean adults with high-grade upper tract urothelial carcinoma (a type of cancer in the kidney or ureter) to monitor for cancer recurrence. Participants will receive standard treatment (chemotherapy before surgery to remove the kidney and ureter) and provid…

This study is following 81 adults with a rare condition called hemophagocytic lymphohistiocytosis (HLH), where the immune system becomes dangerously overactive. Researchers aim to better understand the disease's features and how patients respond to treatments like steroids and ch…

This study screens up to 797 people with relapsed small cell lung cancer to identify genetic changes in their tumors. It does not test any new drugs. Instead, it uses tissue and blood samples to find molecular subtypes, which may help patients qualify for future targeted therapy …

This study looks at 100 adults with advanced breast cancer to see if a special type of PET-CT scan (called F-18 FDG PET-CT) is better than standard imaging at tracking how well the first round of cancer treatment is working. Participants will have both types of scans over 48 week…

This study aims to use artificial intelligence to find patterns in patients with acute respiratory failure, a serious condition where the lungs can't get enough oxygen. Researchers will collect data from 250 adults in the ICU to create a model that groups patients by their traits…