Samsung Medical Center

This study looks at whether people with a high risk of bleeding who have stable coronary artery disease can safely stop taking antiplatelet medication (blood thinners) after a drug-coated balloon angioplasty. Participants must have been on standard blood thinners for at least a y…

This study tests whether combining two targeted drugs, lazertinib and tepotinib, can shrink tumors in people with a specific type of advanced lung cancer (EGFR-mutant NSCLC) that stopped responding to lazertinib alone. It includes 47 adults whose tumors show a change called MET o…

This study looks at whether starting heart rhythm control early can help people who have both atrial fibrillation (an irregular heartbeat) and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be assigned to either early rhythm control or usual care. Th…

This study tests whether starting kidney dialysis early helps people with severe heart shock who are on a heart-lung machine (ECMO). About 408 adults with both heart and kidney failure will be randomly assigned to early or standard dialysis. The goal is to see if early treatment …

This study tests whether giving the immunotherapy drug avelumab after standard chemotherapy can help prevent upper tract urothelial cancer from coming back. About 48 adults who have already completed chemotherapy and show no signs of cancer will receive avelumab every two weeks f…

This study compares two drug combinations—aspirin plus prasugrel versus aspirin plus clopidogrel—in 3,500 adults with complex coronary artery disease who are getting stents. The goal is to see which combo better prevents major heart problems like death, heart attack, or stent blo…

This study is for men whose prostate cancer has come back after surgery, shown by rising PSA levels. It compares a standard 4-week radiation course to a shorter, more intense 1-week course. The goal is to see if the shorter treatment works just as well to control the cancer while…

This study tests whether the drug osimertinib can stop or shrink small, hazy lung spots (called ground-glass nodules) that remain after surgery for a type of lung cancer. About 59 adults with EGFR-mutant lung adenocarcinoma will take one pill daily. The goal is to see if the drug…

This study tests a new drug, selinexor, added to standard chemotherapy for people with a type of blood cancer (B-cell lymphoma) that has come back or not responded to treatment and has spread to the brain. The goal is to see if the combination is safe and works better than curren…

This study tests whether a drug-coated balloon works better than a drug-eluting stent for treating complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two procedures. The goal is to see which approach reduces …

This study looks at 2,000 people with chest pain and moderate coronary artery blockages seen on a CT scan. It compares an invasive approach (like stenting or bypass) with a non-invasive approach (medication and lifestyle changes) to see which leads to fewer heart attacks, deaths,…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can help control the condition. About 520 adults with these hidden AF episodes will be randomly assigned to either early rhythm control therapy (medication, sh…

This study tests whether adding a special type of radiation (Adaptive Pulse Radiotherapy) to standard immunotherapy can help control advanced solid tumors. About 35 adults with cancer who are already receiving or planning to receive immunotherapy will get 2-3 high-dose radiation …

This study compares two procedures for removing small precancerous growths in the stomach. One method cuts out the growth, while the other uses a gas-based tool to burn it away. Researchers want to see if the simpler gas method works just as well and causes fewer side effects. Ab…

This study compares a newer pacing method, left bundle branch area pacing (LBBAP), to the standard right ventricular pacing (RVP) in 200 patients with heart block and normal heart function. The goal is to see if LBBAP better preserves heart pumping ability and reduces complicatio…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This study tests a new radiation approach called PULSAR, which delivers short, powerful proton beam pulses spaced weeks apart, allowing the body to recover between treatments. It is for people with pancreatic cancer that has not spread far. The goal is to see if this method, comb…

This study looks at whether a small, wearable continuous glucose monitor (CGM) can accurately diagnose dumping syndrome in people who have had surgery for esophageal cancer. Dumping syndrome happens when food moves too quickly into the small intestine, causing symptoms like dizzi…

This study tests a personalized approach to brain stimulation (rTMS) for people with Parkinson's disease. The goal is to see if tailoring the stimulation to each patient's brain function improves walking better than the standard one-size-fits-all method. The study will involve 60…

This study tests a smartphone app that provides personalized exercise and education after rotator cuff repair surgery. It aims to improve shoulder function and reduce pain compared to standard care. The trial involves 70 adults who have had this surgery and own a smartphone.

This study tests whether adjusting a pacemaker to each patient's ideal heart rate can reduce heart failure symptoms. About 106 adults with heart failure and slow heart rates will receive either standard or personalized pacemaker settings. The goal is to see if the tailored approa…

This study is following 81 adults with a rare condition called hemophagocytic lymphohistiocytosis (HLH), where the immune system becomes dangerously overactive. Researchers aim to better understand the disease's features and how patients respond to treatments like steroids and ch…

This study is collecting medical information and tissue samples from 350 head and neck cancer patients at Samsung Medical Center. Researchers want to understand why some patients respond better to treatment than others, especially looking at genetic differences and HPV infection.…

This study looks at 30 adults with advanced head and neck cancer who are receiving standard immunotherapy plus chemotherapy. The goal is to find biological markers in tumors and blood that can predict who will benefit from treatment. By understanding these changes, doctors hope t…

This study screens up to 797 people with relapsed small cell lung cancer to identify genetic changes in their tumors. It does not test any new drugs. Instead, it uses tissue and blood samples to find molecular subtypes, which may help patients qualify for future targeted therapy …

This study is collecting information from 2,200 children (ages 0-12) who visit the emergency room with breathing problems. Researchers will use videos and medical data to train an artificial intelligence system that can automatically analyze breathing patterns. The goal is to hel…

This study looks at 100 adults with advanced breast cancer to see if a special type of PET-CT scan (called F-18 FDG PET-CT) is better than standard imaging at tracking how well the first round of cancer treatment is working. Participants will have both types of scans over 48 week…

This study follows 300 Korean adults with high-grade upper tract urothelial carcinoma (a type of cancer in the kidney or ureter) to monitor for cancer recurrence. Participants will receive standard treatment (chemotherapy before surgery to remove the kidney and ureter) and provid…

This study aims to find genetic markers in tissue and blood that can help doctors better diagnose early stomach cancer and precancerous growths, and predict if the cancer will come back after treatment. Researchers will analyze samples from 1,730 adults who have already been diag…

This study aims to create and test a way to set personalized goals for children in the pediatric intensive care unit (PICU). Researchers will first ask a group of experts to agree on the best methods, then try these methods with a small number of caregivers and hospital staff. Th…

This study is creating a large, organized database of up to 800,000 Korean patients with heart or brain blood vessel diseases. Researchers will collect medical history and follow patients over many years to understand how these diseases progress and what factors affect outcomes. …

This study aims to use artificial intelligence to find patterns in patients with acute respiratory failure, a serious condition where the lungs can't get enough oxygen. Researchers will collect data from 250 adults in the ICU to create a model that groups patients by their traits…