Nationwide Children's Hospital

This study tested a drug called GM-CSF in 75 children with sepsis who had organ failure and a weakened immune system (immunoparalysis). The goal was to see if a 7-day course of GM-CSF could restore their immune function. The researchers compared two doses and two ways of giving t…

This study tested a new chemotherapy combination (GemPOx) followed by a single round of very high-dose chemotherapy and a stem cell transplant in 10 patients with recurrent or progressive brain germ cell tumors. The goal was to see if this approach could shrink or control the tum…

This study tested whether the drug GM-CSF could help children with sepsis who have a weakened immune system. 141 children with multiple organ failure were given either GM-CSF or a placebo. The goal was to see if the drug could improve organ function and quality of life over 28 da…

This study looked at whether giving fentanyl test strips and naloxone to people in Ohio drug courts can help prevent overdoses. Over 650 adults who used stimulants like cocaine or methamphetamine took part. The goal was to see if this approach is practical and acceptable, and whe…

This study tested a treatment called posterior tibial nerve stimulation (PTNS) for children ages 8-18 with constipation caused by pelvic floor dyssynergia. Researchers compared real PTNS to a sham (fake) treatment in 40 children to see if it improves bowel function. The goal was …

This study tested whether baclofen, a muscle relaxant, can reduce vomiting in children with rumination syndrome. Fifty children aged 4 to 18 took either baclofen or a placebo for 4 weeks. The main goal was to see if more children on baclofen vomited once a week or less compared t…

This study looked at whether a short video that teaches teens how fear and stress affect pain can help them recover from leg pain. 86 teens aged 12-17 with leg pain that started without an injury took part. They were split into two groups: one watched the special video, the other…

This study tested a treatment called gastric electrical stimulation (GES) in 30 children with severe nausea and vomiting that didn't get better with standard care. GES uses mild electrical pulses to help the stomach work better. For four days the device was off, then on for four …

This study tested a new rehabilitation approach called the Immediate Functional Progression Program (IFPP) for adolescent athletes with spondylolysis, a stress fracture in the lower back. 64 athletes aged 10-19 were randomly assigned to start physical therapy right away or wait u…

This study tested a Spanish-language mobile app (BMT4me) designed to help parents care for children recovering from a bone marrow transplant. Thirty Spanish-speaking caregivers of children who had the transplant used the app and rated how easy it was to use. The goal was to see i…

This study followed 44 adults with a confirmed VCP gene mutation to learn how their disease (IBMPFD) naturally progresses over one year. Participants completed walking tests, strength assessments, and questionnaires about daily function and quality of life. The goal was to gather…

This study tested a non-invasive sticker-like sensor (EMG) to measure how well spinal and caudal anesthesia works in 80 children under 5 during surgery. The goal was to see if the sensor could show when anesthesia starts, how strong it is, and how long it lasts. This was a pilot …