Nationwide Children's Hospital

Researchers are testing whether natural killer (NK) cells from a universal donor can be safely given with standard chemotherapy drugs and an immune-targeting antibody to children and young adults with neuroblastoma that has returned or stopped responding. The NK cells are modifie…

This trial tests a one-time gene therapy injection for people with Charcot-Marie-Tooth disease type 1A (CMT1A), a genetic nerve disorder that causes progressive muscle weakness. The therapy delivers a gene that produces a protein to support nerve health. Three adults aged 18 to 3…

This study tests a new way to do stem cell transplants for 20 children with blood cancers or myelodysplasia who don't have a perfect donor match. Doctors remove certain immune cells from a parent's partially matched stem cells before transplant to help the new cells grow faster a…

This early-phase trial is testing the safety of an experimental drug called PTC596 (Unesbulin) when given alongside radiation therapy to children and young adults newly diagnosed with diffuse intrinsic pontine glioma (DIPG) or high-grade glioma. The study aims to find the safest …

This pilot study tests whether playing a virtual reality game during dermatologic laser procedures can reduce pain and anxiety in children and young adults aged 5 and up. Forty participants will either use VR-PAT or receive standard care. Researchers will measure pain and anxiety…

This study explores whether virtual reality (VR) can help reduce pain and anxiety in children aged 5-17 undergoing joint injections for juvenile idiopathic arthritis. Participants will use a VR headset during the procedure, and researchers will measure how practical it is for nur…

This study tests whether using a special augmented reality (AR) game called Little NIRVANA, along with numbing cream, can help children ages 2 to 8 feel less pain and anxiety when getting an IV in the emergency room. About 130 kids will be randomly assigned to get either the AR g…

This trial tests whether a smartphone-based virtual reality tool (VR-PAT) can reduce pain during at-home burn dressing changes in children aged 6 to 17. Half of the 200 participants will use VR-PAT during their daily dressing changes, while the other half will not. Researchers wi…

This study planned to test whether the painkiller ketorolac is safe and effective for newborns (up to 3 months old) after abdominal surgery. Researchers wanted to compare bleeding and pain control between babies given the drug and those given a placebo. However, the study was wit…

This study planned to compare three different medications given as nose sprays to children aged 2 to 6 years who needed stitches for a cut. The goal was to see which one worked best for pain and anxiety during the procedure. However, the trial was withdrawn before any children we…

This study will test a device called TetraGraph that measures muscle response to electrical stimulation. It will track how quickly the muscle relaxant rocuronium takes effect and wears off in 130 children having surgery. The goal is to help doctors know the best time to place a b…

This study looks for early signs of necrotizing enterocolitis (NEC), a severe gut infection in premature babies. Researchers will use non-invasive measures and blood markers to identify at-risk infants before symptoms start. The goal is to eventually prevent the disease from prog…

This study looks at whether teaching people who use drugs how to use fentanyl test strips can help prevent overdoses. About 2,400 adults in Ohio will take part at Project DAWN sites. Some will get the test strip education, while others will just get the usual overdose prevention …

This study will use brain imaging to understand how virtual reality (VR) helps children manage pain. Twenty healthy kids aged 6-17 will wear a blood pressure cuff to create mild pain while playing VR games, watching a passive VR video, or using an iPad. Researchers will measure b…

This study follows 526 preterm infants born before 30 weeks who have a condition called patent ductus arteriosus (PDA), where a fetal blood vessel stays open too long. Researchers collect heart ultrasound, blood, and urine tests over the first month to predict which babies will c…

This study uses a non-invasive surface EMG device (sensor stickers on the skin) to measure how well regional anesthesia (nerve blocks) works during surgery in children and young adults up to age 21. The goal is to learn how to give nerve blocks more safely and effectively. Partic…

This study looks at blood samples from 84 children aged 4-17 having their tonsils removed to find chemical clues about why Black children often report more pain afterward. Researchers will measure pain scores and compare blood metabolites between racial groups. The goal is to und…