Nationwide Children's Hospital

This study is testing the safety of a new oral drug called PTC596 (Unesbulin) when given alongside standard radiation therapy to children and young adults newly diagnosed with aggressive brain tumors, including a very hard-to-treat type called DIPG. The main goals are to find the…

This study is testing whether a virtual reality game can help reduce pain and anxiety for children and young adults during repeated laser skin procedures. About 40 participants aged 5 and older will try the VR game during one laser session and a non-game VR headset during another…

This study is testing whether a special augmented reality game, called Little NIRVANA, can help reduce pain and anxiety for young children (ages 2-8) when they need an IV placed in the emergency room. Children will be randomly assigned to either play the game during the procedure…

This study aimed to see if a pain medication called ketorolac is safe and effective for newborns (1 week to 3 months old) after abdominal surgery. It planned to compare ketorolac against a placebo to check for bleeding risks and see if it could reduce the need for stronger narcot…

This study aimed to find out which of three nasal spray medications works best to reduce pain and anxiety in young children getting stitches in the emergency room. It planned to compare dexmedetomidine, fentanyl, and midazolam sprays in kids aged 2 to 6. The trial was withdrawn b…

This study aims to understand why children of different races may experience different levels of pain after tonsil removal surgery. Researchers will analyze blood samples from 84 children to look for unique chemical patterns linked to severe pain. The goal is to uncover the biolo…

This study aims to understand how the brain responds to pain and how virtual reality (VR) might help manage it. Researchers will scan the brains of 20 healthy children while they experience mild simulated pain and play different VR and iPad games. The goal is to find brain signal…

This study is testing a new way to measure how well a nerve block (regional anesthesia) is working during surgery. Researchers will place special sticker sensors on the arms or legs of children and young adults having surgery. The goal is to see if these sensors can provide bette…

This study aims to help doctors predict which premature babies with a common open heart vessel (PDA) will heal on their own and which need treatment. Researchers will follow over 500 preterm infants, using heart ultrasounds and blood tests in their first month to find early signs…