Nationwide Children's Hospital

This study is testing a new way to do stem cell transplants for children with blood cancers or bone marrow disorders. Instead of needing a perfectly matched donor, doctors use a partially matched family donor and remove certain immune cells from the donated cells to reduce the ri…

This study is testing a new drug called PTC596 (Unesbulin) given alongside radiation therapy for children and teens (ages 1-21) newly diagnosed with aggressive brain tumors like DIPG or high-grade glioma. The main goal is to find a safe dose and check for side effects. Participan…

This study looks at whether giving people who use drugs fentanyl test strips and education at overdose prevention sites can help reduce overdoses. About 2,400 adults in Ohio will take part. Researchers will track how many overdoses happen and whether the strips change behavior.

This study tests whether playing a virtual reality game can help children and young adults feel less pain and anxiety during laser skin treatments. About 40 people aged 5 and older will either use VR or receive standard care. The goal is to see if VR is a practical and effective …

This study tests whether using an augmented reality (AR) game called Little NIRVANA, along with numbing cream, can reduce pain and anxiety in children aged 2 to 8 years old when they get an IV in the emergency department. About 130 children will take part. The goal is to see if t…

This study aimed to compare three different nose sprays (dexmedetomidine, fentanyl, and midazolam) for reducing pain and anxiety in young children (ages 2-6) getting stitches in the emergency room. The goal was to see which spray worked best and was safest. However, the study was…

This study planned to test whether a pain medicine called ketorolac is safe and effective for newborns up to 3 months old after abdominal surgery. The goal was to see if it could reduce the need for stronger narcotic painkillers. However, the study was withdrawn before any babies…

This study tests a non-invasive sticker sensor (surface EMG) to measure how well nerve blocks work during surgery in children and young adults up to age 21. The sensor records muscle electrical activity before, during, and after surgery. The goal is to learn how to give nerve blo…

This study looks at how virtual reality (VR) affects pain in the brain. Twenty healthy children aged 6 to 17 will wear a blood pressure cuff to create mild pain and a brain scanner while using VR games, a VR video, or an iPad game. The goal is to find brain signals that show when…

This study follows 526 preterm infants born before 30 weeks who have a condition called patent ductus arteriosus (PDA), where a fetal blood vessel stays open too long. Researchers want to find out which babies will close this vessel on their own and which ones are at risk for ser…

This study examines why Black children often report more pain after tonsil removal than White children. Researchers will analyze blood samples from 84 children aged 4-17 to find chemical differences that might explain this disparity. The goal is to better understand the biology b…