Memorial Sloan Kettering Cancer Center

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread live longer. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will als…

This study tests whether a new drug (BMS986365) combined with hormone therapy (degarelix) can safely shrink or eliminate high-risk prostate cancer before surgery. About 30 adults with localized high-risk prostate cancer will receive the drug combo for a few months, then have thei…

This study tests a new drug called 2141-V11 that helps the immune system find and kill prostate cancer cells. It is given as an injection directly into the tumor, either alone or with standard hormone therapy. The goal is to see if this approach can completely eliminate cancer or…

This study tests a mix of immune cells (agenT-797) and three immunotherapy drugs (botensilimab, balstilimab, ramucirumab) plus chemotherapy (paclitaxel) for people with advanced stomach, esophageal, or gastro-esophageal junction cancer that has worsened after one prior treatment.…

This study tests whether two drugs, mirdametinib and palbociclib, can safely control advanced liposarcoma that has spread or cannot be removed by surgery. About 54 adults with this rare cancer will receive different doses to find the best balance of safety and effectiveness. The …

This study tests the drug ruxolitinib in people with T or NK cell lymphoma that has come back or not responded to treatment. Ruxolitinib blocks a protein that helps these cancer cells survive, which may shrink the tumors. About 83 adults will take part to see if the drug can cont…

This study tests whether giving the drug trastuzumab deruxtecan before routine surgery can shrink tumors in people with a specific type of lung cancer (HER2-amplified or HER2-mutated non-small cell lung cancer). About 14 adults with stage II to IIIB lung cancer will receive the d…

This study tests whether adding certolizumab (an anti-inflammatory drug) to standard chemotherapy before surgery can shrink stage II-III lung cancers more than chemo alone. About 60 adults with operable lung cancer will receive the combination, then have surgery to remove any rem…

This study tests whether a combination of three drugs (zanubrutinib, obinutuzumab, and venetoclax) can make chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) undetectable in the body. About 230 adults who have not had prior treatment for these blood cancers w…

This study is testing whether a special PET scan called 68Ga PSMA-PET/CT can find cancer spots in people with advanced bladder cancer or melanoma that has spread. About 20 participants will get both the new scan and the standard scan to compare. The goal is to see if the new scan…

This study tests a new dye called pHLIP ICG that makes breast cancer cells glow during surgery, helping surgeons see and remove all cancer. About 55 adults with early-stage breast cancer will get the dye before surgery. The goal is to see if this method is safe and improves cance…

This study looks at whether a plant-based diet, omega-3 and curcumin supplements, or a placebo can change gut bacteria in people with early blood conditions called MGUS and smoldering multiple myeloma. The goal is to see if these changes might help prevent the conditions from tur…

This study compares two types of virtual therapy—music therapy and cognitive-behavioral therapy—to see which better reduces anxiety in people who have had cancer. Researchers will enroll 368 adult cancer survivors with ongoing anxiety. The goal is to find out if personal traits l…

This study tests whether a single 60-minute counseling session can reduce anxiety and depression in breast cancer patients who are waiting for ongoing therapy. Twenty participants will try the session and report how helpful it was. The goal is to see if this quick support can imp…

This study looks at two common practices after bladder cancer surgery: using a ureteral stent (a tube to drain urine) and giving a drug called alvimopan to help the bowels work again. The goal is to see if avoiding stents reduces urinary tract infections and if alvimopan shortens…

This study tests whether tirzepatide and semaglutide (weight loss drugs) are practical and safe for endometrial cancer patients who are overweight, obese, or have diabetes and are receiving chemotherapy. About 36 adults will take weekly doses for 24 weeks. Researchers will track …

This study tests whether Revaree Plus, a vaginal moisturizer, can improve vaginal dryness in women with hormone-receptor-positive breast cancer. About 60 participants who have completed primary cancer therapy or are on maintenance treatment will use the product for 8 weeks. The g…

This study asks informal caregivers (family or friends) of people with Erdheim-Chester disease and similar conditions about their supportive care needs. Researchers will use a questionnaire to measure quality of life and identify areas where caregivers need more help. The goal is…

This study is testing a questionnaire called PRO-AYA, designed to measure health and well-being in adolescents and young adults (ages 15-39) with cancer. Researchers want to see if the questions are reliable and make sense in both English and Spanish. About 120 participants will …

This study aims to understand why some people experience low blood pressure after receiving general anesthesia for surgery. Researchers will monitor heart function and blood flow in 250 adults before and after anesthesia. The goal is to identify key changes that lead to this comm…

This study is building a database of health information from 500 adults with painful bone metastases that have spread from other cancers. Researchers will track participants over time to learn more about the disease and how different treatments affect survival. The goal is to gat…

This study looks at how lymphedema patients' quality of life changes over time, comparing those who choose surgery (a lymph node transfer) with those who choose non-surgical care. Researchers will follow 600 adults aged 18 to 80 with arm or leg swelling. The goal is to understand…