Janssen Research & Development, Llc

This study tested a vaccine called ExPEC9V to see if it can prevent severe E. coli infections in adults aged 60 and older who had a urinary tract infection in the past 2 years. The vaccine targets nine common types of E. coli that can cause dangerous infections outside the gut, s…

This study tested a drug called golimumab, given through a vein, for people with active ankylosing spondylitis—a type of arthritis that causes back pain and stiffness. The trial included 208 adults who had not responded well to standard anti-inflammatory drugs. The goal was to se…

This study tested a combination of ibrutinib and rituximab against other standard treatments for people with mantle cell lymphoma that had come back or stopped responding. The main goal was to monitor side effects and provide continued access to treatment for those who were benef…

This study tested whether adding apalutamide to standard hormone therapy after prostate removal surgery could delay cancer recurrence in 108 high-risk patients. The main goal was to see how many men had no sign of cancer (measured by PSA levels) after 24 months. Results suggest t…

This study tested a drug called erdafitinib in 316 adults and children with advanced solid tumors that have certain changes in FGFR genes. The main goal was to see if the drug could shrink tumors. Participants had already tried at least one other treatment. The study is now compl…

This study tested a drug called golimumab in 130 children with active juvenile idiopathic arthritis (JIA) that was not controlled by methotrexate. The drug was given through a vein (IV) to see how it moves through the body and how well it works. The goal was to help control the d…

This study tested a daily pill called erdafitinib against standard chemotherapy placed directly into the bladder for people with a high-risk type of bladder cancer that came back after BCG treatment. Only patients whose tumors had certain FGFR gene changes were included. The goal…

This study tested a new blood thinner pill called milvexian in over 14,000 people who recently had a heart attack or unstable angina. The goal was to see if adding milvexian to standard care could lower the chance of another heart attack, stroke, or death from heart problems. Par…

This study tested an experimental drug called nipocalimab in 228 adults with active systemic lupus erythematosus (SLE). Participants received either the drug or a placebo to see if it could reduce lupus symptoms and disease activity. The goal was to control the disease, not cure …

This study tested a drug called M281 in 25 pregnant women whose babies were at high risk for a severe blood disorder (HDFN). The goal was to see if the drug could help more babies survive to at least 32 weeks without needing a risky blood transfusion before birth. The study focus…

This study tested a gene therapy (AAV5-RPGR) for people with X-linked retinitis pigmentosa, a genetic eye disease that causes vision loss. 105 participants received the treatment or a control. The main goal was to see if it improved their ability to navigate a maze after one year…

This study tested an experimental drug called JNJ-77242113 in 255 adults with moderate-to-severe plaque psoriasis. Participants took different doses of the drug or a placebo for 16 weeks. The main goal was to see if the drug could clear at least 75% of psoriasis patches. This is …

This early-stage study tested a new drug called JNJ-74856665 in 153 people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal was to find safe doses and check for side effects. The drug works by blocking a key enzyme cancer cells need to grow. Thi…

This study tested three different schedules of the drug daratumumab in 123 people with smoldering multiple myeloma, a condition that often leads to active cancer. The goal was to see which dose schedule best controlled the disease and reduced cancer cells. Participants had interm…

This study tested a drug called ustekinumab in 112 children with moderate-to-severe ulcerative colitis, a chronic bowel disease. The goal was to see if the drug could reduce symptoms like diarrhea and bleeding and help the colon heal. Children first received the drug through an I…

This study followed 42 people with X-linked retinitis pigmentosa, an inherited eye disease that causes vision loss, for up to 5 years after they received a gene therapy. The goal was to check the long-term safety of the treatment and see if it helped with functional vision, like …

This early-phase study tested a new drug called JNJ-70218902 in 82 people with advanced solid tumors, including prostate cancer. The goal was to find a safe dose and check for side effects. The drug works by redirecting the body's T cells to attack cancer cells, but it is not a c…

This early-phase study tested an experimental drug called JNJ-75348780 in 147 people with two types of blood cancer (non-Hodgkin lymphoma and chronic lymphocytic leukemia) that had returned or stopped responding to other treatments. The drug is designed to help the immune system …

This early-stage study tested a new drug called JNJ-64619178 in 114 people with advanced cancers, including lymphoma and solid tumors. The main goal was to find the safest dose and check for side effects. The drug works by blocking a protein that helps cancer cells grow.

This study tested the drug guselkumab in 213 adults with skin of color who have moderate-to-severe plaque or scalp psoriasis. Participants received either the drug or a placebo for 16 weeks. The main goal was to see if guselkumab could clear at least 90% of psoriasis patches on t…

This study tested a new gene therapy, JNJ-81201887, in 305 people with geographic atrophy (advanced dry age-related macular degeneration). The goal was to see if a single injection into the eye could slow the growth of blind spots compared to a sham procedure. The therapy aims to…

This study looked at whether ustekinumab (STELARA) is safe and effective for Chinese adults with moderate to severe Crohn's disease. 182 participants received the drug and were followed for 52 weeks. The main goals were to see if symptoms improved by week 8 and if gut healing occ…

This early-phase study tested a new treatment called JNJ-75229414, which uses a patient's own immune cells (CAR-T cells) to target a protein found on prostate cancer cells. The study involved 15 men with metastatic castration-resistant prostate cancer who had already tried other …

This study tested whether combining two drugs (guselkumab and golimumab) works better than one drug alone for active psoriatic arthritis. 91 adults who had not responded well to previous TNF-alpha therapy participated. The main goal was to see if more people reached a state of mi…

This study tested a new oral medication, JNJ-77242113, in 227 adults with moderate-to-severe plaque psoriasis who had already completed a previous 16-week study. The goal was to see how well the drug worked over 36 weeks, measuring skin improvement using the Psoriasis Area Severi…

This study tested an experimental drug called JNJ-77242113 in 252 adults with moderate to severe ulcerative colitis. The goal was to see if the drug could reduce symptoms like diarrhea and rectal bleeding better than a placebo. Participants took the drug or a placebo for 12 weeks…

This study tested a medicine called ustekinumab in 101 children with moderate-to-severe Crohn's disease. The goal was to see if the drug could reduce symptoms and keep the disease under control. Children first received the drug through an IV, then some continued with injections t…

This study tested an experimental oral tablet (JNJ-77242113) against a placebo in 90 adults with moderate-to-severe plaque psoriasis. The main goal was to see if the pill could reduce psoriasis severity by at least 75% after 16 weeks. Participants had to have psoriasis for at lea…

This study tested a new combination of drugs (daratumumab, lenalidomide, and dexamethasone) in 45 adults whose multiple myeloma had returned or stopped responding to treatment. The main goal was to check safety and find the right dose, while also measuring how well the drugs shra…

This study tested whether adding daratumumab to standard chemotherapy (CyBorD) helps people newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins build up in organs. Over 400 adults took part. The goal was to see if the combination leads to better blood resp…

This study looked for special markers in the blood that could help doctors find pulmonary hypertension (high blood pressure in the lungs) earlier. Researchers tested blood samples from over 900 people and compared the results to a standard heart test. The goal is to create a simp…

This study tested whether a new vaccine against a serious E. coli infection (ExPEC9V) can be given at the same time as a high-dose flu shot in adults aged 65 and older. The goal was to make sure the immune response to both vaccines stays strong when given together. About 959 heal…

This study tested a new vaccine called ExPEC10V to see if it is safe and can help prevent infections caused by a type of E. coli bacteria outside the intestines. The study included 836 adults aged 60 to 85 who were in stable health. Researchers gave different doses of the vaccine…

This study tested a drug called seltorexant in 588 adults with major depression and insomnia who were not fully helped by their current antidepressant. Participants took either seltorexant or a placebo pill alongside their regular antidepressant for about 6 weeks, with a longer s…

This study tested whether adding aticaprant to standard antidepressants helps adults with major depression who still feel little pleasure or interest (anhedonia). 444 participants received either aticaprant or a placebo pill for about 6 weeks. The main goal was to see if depressi…

This study tested a drug called aticaprant in 513 adults with major depression who still had symptoms—especially loss of interest or pleasure (anhedonia)—even after taking standard antidepressants. Participants took either aticaprant or a placebo pill alongside their usual antide…

This study tested a drug called guselkumab against a placebo in 338 adults with moderate plaque psoriasis that also affects special sites like the scalp, nails, or genitals. The goal was to see if the drug could clear or nearly clear the psoriasis in those areas. Results showed t…

This early-stage study tested how a long-acting HIV medication (rilpivirine, given alone or with cabotegravir) moves through the body after a single injection under the skin. 126 healthy adults took part to check safety and drug levels. The goal was not to treat disease, but to g…

This study observed 545 adults with major depression and anhedonia (loss of interest or pleasure) who were not helped enough by their current antidepressants. Researchers tracked their personal and medical backgrounds, treatment patterns, and outcomes like sexual function and rel…

This study followed 17 pregnant women and their babies who were at high risk for a severe blood condition called hemolytic disease of the newborn. The goal was to learn how the condition is currently managed and what happens to mothers and babies. Researchers tracked treatments l…