Janssen Research & Development, Llc

This study tested an experimental drug called JNJ-63733657, designed to target tau protein tangles in the brain, in people with early Alzheimer's disease. The goal was to see if it could slow down memory loss and daily function decline compared to a placebo. The trial was termina…

This study tested whether adding the drug aticaprant to standard antidepressant therapy could prevent depression from returning in people with major depressive disorder who also experience a loss of interest and pleasure (anhedonia). The study was terminated early and involved 47…

This study tested a drug called aticaprant added to standard antidepressants for people with major depression who still feel no pleasure or interest (anhedonia). The trial was stopped early, but researchers wanted to see if aticaprant could improve mood and pleasure more than a p…

This study looked at the long-term safety of adding aticaprant to standard antidepressants for adults with major depressive disorder. About 871 people were planned to take part, but the trial was stopped early. The main goal was to track side effects and other safety measures ove…