Institut National De La Santé Et De La Recherche Médicale, France

This study looks for signs of endometriosis in menstrual blood, which is easy to collect. Researchers will compare samples from 250 women with and without the condition, and also check if these signs change after surgery. The goal is to create a simple, non-invasive test to diagn…

This study tests whether numbing a nerve in the arm or leg can reduce the burning or aching pain that some people feel after a stroke. About 36 adults who have had a stroke at least 6 months ago and have had pain for at least 6 months will receive two injections (either a numbing…

This study aims to understand how 9 rare skin diseases affect people's lives beyond just physical symptoms. Researchers will survey 900 patients and their families to measure the emotional, social, and financial burden. The goal is to create a tool that helps doctors and caregive…

This study aims to find early markers for ALS by analyzing blood, tears, urine, and spinal fluid from 60 people. It includes those with ALS gene mutations but no symptoms, early-stage ALS patients, and healthy controls. The goal is to enable earlier diagnosis and better treatment…

This study follows 700 people with Alport syndrome, a rare inherited disease that can cause kidney failure, hearing loss, and eye problems. Researchers will collect health data over time to learn how the disease progresses and find early signs of kidney damage. The goal is to pre…

This study looks at 300 people with rare autoinflammatory diseases to find new genes and biological signs that cause these conditions. Researchers will use advanced genetic testing and blood analysis to better understand the disease pathways. The goal is to improve diagnosis and …

This study follows 800 children from birth to age 10 who have rare eye malformations like missing eyes (anophthalmia), small eyes (microphthalmia), or missing iris (aniridia). Researchers will track vision, brain development, and other health issues over time to better predict ou…

This study aims to uncover the genetic causes of Developmental Language Disorder (DLD), a condition where children have trouble learning language without other known medical issues. Researchers will analyze the DNA of 50 children with severe DLD and their families using advanced …

This study looks at why the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells and DNA from 200 adults to understand how these diseases develop and progress. The goal is to learn more, not to test a …

This study aims to create a large collection of medical images (MRI and ultrasound) of the heart, liver, and blood vessels from 2,400 healthy volunteers across France. By analyzing these images alongside factors like age and sex, researchers hope to establish what 'normal' looks …

This study looks at the genes of 3,800 people with autism to find genetic changes that could lead to new treatments. Researchers will analyze DNA from large groups of patients, focusing on genes linked to brain cell communication. The goal is to better understand the biology of a…

This study looks at why some women with anorexia nervosa get better after treatment but then relapse. Researchers will use brain scans, thinking tests, and blood samples to find clues. The goal is to understand the disease better, not to test a new treatment. About 275 women with…

This study aims to find out why some people with fatty liver disease or alcohol-related liver disease develop liver cancer. Researchers will study genetic markers and immune factors in 710 adults, both with and without cirrhosis. The goal is to identify early warning signs, espec…

This study is creating a tool to help doctors diagnose and choose treatments for autoimmune diseases. Researchers will analyze blood samples from 500 children with and without these conditions to find unique molecular patterns. The goal is to make diagnosis faster and treatments …