Genentech, Inc.

This early-stage trial is testing a new drug called GDC-0587, both alone and combined with another cancer drug called giredestrant. It's for people with advanced ER-positive, HER2-negative breast cancer that has continued to grow despite previous treatment with CDK4/6 inhibitor d…

This study is testing a new drug called RO7446603, given as an injection into the eye, to see if it is safe and can help improve vision in people with diabetic macular edema (DME). DME is a swelling in the back of the eye that causes vision loss in people with diabetes. Researche…

This study is testing whether adding a personalized cancer vaccine and an immunotherapy drug to standard chemotherapy is better than chemotherapy alone at preventing pancreatic cancer from coming back after surgery. It will involve about 260 people whose pancreatic tumors have be…

This study aims to see if a refillable implant that continuously delivers medication into the eye affects the health of the cornea, the eye's clear front layer. It will involve about 188 people with wet age-related macular degeneration who receive the implant. Researchers will co…

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This early-stage study is testing an investigational drug called vixarelimab in people with moderate to severe ulcerative colitis (UC) who haven't responded well to other treatments. The main goal is to see how the drug affects the gut and to check its safety. Researchers will en…

This study is testing whether giving specific, personalized drug treatments before and after surgery can better control early-stage lung cancer. It is for people whose tumors have certain genetic markers. The goal is to see if these targeted approaches shrink tumors more effectiv…

This early-stage trial is testing a new type of cell therapy called P-CD19CD20-ALLO1 in people with severe lupus that hasn't responded to multiple treatments. Researchers will give 162 participants modified immune cells designed to target and remove the faulty B-cells that drive …

This study is testing a new drug called RO7837195 for adults with moderate to severe ulcerative colitis who haven't gotten better with other treatments. It aims to see if the drug can reduce symptoms and gut inflammation better than a placebo. The trial includes an initial 12-wee…

This early-stage study is testing the safety and best dose of a new two-drug combination (cevostamab and elranatamab) for people with multiple myeloma that has returned or stopped responding to other treatments. The main goals are to see what side effects occur and to find the ri…

This study aims to check the safety of two different drug treatments for people with advanced liver cancer that cannot be removed by surgery. It focuses on patients who also have significant liver damage (scarring) from cirrhosis. Researchers will test a two-drug combination and …

This study is testing a new cell therapy called OpRegen for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes progressive vision loss. Doctors will inject the therapy under the retina during eye surgery to see if it is safe and i…

This early-stage study is testing a new type of immune cell therapy called P-CD19CD20-ALLO1 in people with multiple sclerosis. The main goal is to check if the treatment is safe and how the modified cells behave in the body. Researchers will enroll 60 adults with either progressi…

This is a first-in-human study to test the safety, side effects, and best dose of a new investigational drug called RO7566802. It will be given alone and in combination with an existing immunotherapy drug (atezolizumab) to up to 250 adults with advanced solid tumors that have spr…

This study is testing a new inhaled drug called GDC-6988 to see if it is safe and can help people with chronic lung diseases where thick mucus builds up. It will involve about 128 adults with conditions like COPD or bronchiectasis. Researchers will measure how the drug affects mu…

This study is testing a new drug called GDC-7035, both alone and combined with other cancer treatments, for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The main goals are to find a safe dose and see how the body processes the drug. It w…

This is an early-stage study to test the safety and side effects of a new drug, RO7656594, in men with advanced or metastatic prostate cancer that has progressed after standard treatments. The main goals are to find a safe dose and see how the body processes the drug. Researchers…

This study is testing a new drug called GDC-4198 for people with advanced breast cancer that has stopped responding to standard treatments. Researchers will compare GDC-4198 alone and combined with another drug against the current standard treatment to see which works better and …

This study is testing whether an investigational drug called GDC-8264 can prevent serious kidney injury in people undergoing major heart surgery. It will involve about 404 adults who are at moderate to high risk for kidney problems after their operation. Participants will receive…

This study is testing how liver problems affect how the body processes a single dose of the cancer drug inavolisib. Researchers will compare people with moderate or severe liver impairment to healthy people with normal liver function. The goal is to understand if liver problems c…

This study aims to compare two different injection methods for delivering trastuzumab, a medication used to treat certain cancers. It will involve 312 healthy male volunteers to see if both methods deliver the drug similarly into the body and to check for side effects. The goal i…

This early-stage study aims to understand how eating food and taking a common stomach acid medicine (rabeprazole) affect how the body absorbs a new drug called ZN-A-1041. It will involve 48 healthy volunteers who will take the drug under different conditions (like with a high-fat…

This study is collecting information about what happens when pregnant women take mycophenolate medications, which are used for organ transplants and autoimmune diseases. Researchers will follow 500 pregnant women in the U.S. who are exposed to these drugs to track pregnancy compl…