Genentech, Inc.

This study is testing if adding a drug called venetoclax to a standard BTKi therapy can create a very deep remission for people with chronic lymphocytic leukemia (CLL). The goal is to see if this deep remission is strong enough to allow patients to safely stop all treatment for a…

This early-stage study is testing new drug combinations for people with advanced melanoma that has a specific genetic change (NRAS mutation) and has stopped responding to standard immunotherapy. Researchers want to see if belvarafenib works better alone or when combined with othe…

This study is testing how well an eye injection called faricimab works for diabetic macular edema (DME), a swelling in the back of the eye that can cause vision loss. It focuses on enrolling 218 adults from racial and ethnic groups that are often underrepresented in medical resea…

This study allows people with metastatic breast cancer who were benefiting from a targeted drug called trastuzumab emtansine in a previous trial to continue receiving it. The main goal is to monitor the long-term safety of the treatment in about 720 participants. It is not testin…

This early-stage study is testing the safety and initial effectiveness of a new drug called RO7496353 when given with an existing immunotherapy drug, with or without standard chemotherapy. It is for adults with advanced solid tumors that have spread or cannot be cured, including …

This study follows 404 adults and children with spinal muscular atrophy (SMA) who are already taking the approved drug risdiplam (Evrysdi). Researchers will track patients for about two years to monitor the long-term safety of the medication and see how well it continues to work.…

This early-stage study is testing the safety and dosing of an experimental pill called inavolisib. It is for people with advanced breast cancer or other solid tumors that have a specific genetic change called a PIK3CA mutation. The study will give the pill alone or in combination…

This is an early-stage study to check the safety and side effects of a new drug called RO7497372, given as an injection into the eye, for people with diabetic macular edema (DME). The study has two parts: first to find safe dose levels, and second to test two selected doses more …

This study is testing whether a new drug called giredestrant, when combined with everolimus, works better than current standard hormone therapies combined with everolimus for people with advanced breast cancer. It's for patients whose cancer has grown despite previous treatment w…

This early-stage study is testing whether two new drugs, XmAb24306 and cevostamab, can be safely given together to people with advanced multiple myeloma that has returned or stopped responding to other treatments. The trial will enroll about 90 patients who have already tried at …

This is an early-stage study to check the safety and side effects of a new drug called XmAb24306. It will be tested alone and in combination with an existing immunotherapy drug (atezolizumab) in about 195 adults with advanced solid tumors that have spread or cannot be cured by su…

This early-stage study is testing the safety and dosing of a new drug called runimotamab. It is being given alone and in combination with an existing cancer drug, trastuzumab, to people with advanced HER2-positive cancers like breast or stomach cancer that have stopped responding…

This early-stage trial is testing the safety and appropriate dosing of an experimental drug called GDC-9545 for advanced breast cancer. The study involves 181 patients with estrogen receptor-positive breast cancer that has spread or returned. Researchers are testing GDC-9545 alon…

This is an early-stage study to find a safe dose and see how the body processes a new drug called GDC-6036. It is being tested alone and with other cancer drugs in people with advanced solid tumors, like lung or colorectal cancer, that have a specific genetic change called KRAS G…

This early-stage trial is testing a new drug called cevostamab, both by itself and in combination with other approved myeloma medications. It aims to find safe doses and see if these treatments can help control multiple myeloma that has returned or stopped responding to other the…

This study is testing a new, more convenient under-the-skin injection of an immunotherapy drug called mosunetuzumab for people with certain types of B-cell lymphoma. It aims to see if this method is safe, effective, and how the body handles the drug. The trial includes people wit…

This study aims to better understand how intermediate age-related macular degeneration (AMD) worsens over time. Researchers will follow 400 participants with early-stage AMD for about 3 years, tracking how quickly their vision changes and measuring specific eye structures. The go…