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Eye disease progression under the microscope: 3-Year study launched

NCT ID NCT05300724

Knowledge-focused Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 2 times

Summary

This study follows 400 people with intermediate age-related macular degeneration (AMD) for about 3 years. Researchers watch how the disease advances to more severe stages and test if measuring the loss of light-sensing cells in the eye can be a useful way to track the disease. No treatment is given; the goal is simply to learn more about how AMD progresses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

400 people

The number who actually took part.

Started

May 2022

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will enroll participants with high risk intermediate AMD.

Ages

50 to 94 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For women of childbearing potential, agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception, during the study for at least 28 days after the last fluorescein injection for the fluorescein angiography (FA) administration * Study eye: High-risk intermediate AMD Exclusion Criteria: * Macular disease in either eye with subretinal deposits not typical of AMD * Pigmentary abnormalities of the retina in either eye not typical of AMD * Atrophy in either eye due to causes other than AMD * Study eye: Any concurrent or history of ocular or intraocular condition * Study eye: Intraocular surgery, including cataract surgery, within 3 months prior to Day 1 * Study eye: Retinal tears or peripheral retinal breaks within 3 months prior to Day 1 * Study eye: Concurrent or history of retinal laser photocoagulation or anti-vascular endothelial growth factor (anti-VEGF) treatment for exudative MNV, diabetic macular edema, retinal vein occlusion, or proliferative diabetic retinopathy * Study eye: Presence of choroidal nevus with overlying drusen in the circle with a radius 3600 micrometer centered on the fovea * Study eye: Previous participation in interventional clinical trials for GA or early stages of AMD, except for vitamins and minerals, regardless of the route of administration within the last 6 months, except for sham-arm participants * Study eye: History of glaucoma surgery, corneal transplant, retinal pigment epithelium tear, retinal tear that involves the macula, retinal detachment * Either eye: Uncontrolled progressive glaucoma * Either eye: Moderate or severe non-proliferative diabetic retinopathy or proliferative diabetic retinopathy * Either eye: History of recurrent infectious or inflammatory ocular disease * Any concurrent or history of taking medications that can induce retinal toxicity

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Age-related macular degeneration

Contacts and locations

Locations

  • ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco

    Milan, Lombardy, 20157, Italy

  • Adelaide Eye and Retina Centre

    Adelaide, South Australia, 5000, Australia

  • Advanced Research

    Coral Springs, Florida, 33067, United States

  • Augenzentrum am St Franziskus-Hospital

    Münster, Germany

  • Austin Clinical Research LLC

    Austin, Texas, 78750, United States

  • Austin Retina Associates

    Austin, Texas, 78705, United States

  • Azienda Sanitaria Universitaria Friuli Centrale ? PO Universitario Santa Maria della Misericordia

    Udine, Friuli Venezia Giulia, 33100, Italy

  • Bay Area Retina Associates

    Walnut Creek, California, 94598, United States

  • CHU de GRENOBLE

    Grenoble, 38043, France

  • Casey Eye Institute - OHSU

    Portland, Oregon, 97239, United States

  • Centre For Eye Research Australia

    East Melbourne, Victoria, 3002, Australia

  • Centre Hospitalier Intercommunal

    Créteil, 94010, France

  • Centre Ophtalmologique Maison-Rouge

    Strasbourg, 67000, France

  • Centre Ophtalmologique Pole Vision

    Écully, 69130, France

  • Cleveland Clinic Cole Eye Institute

    Cleveland, Ohio, 44195, United States

  • Cumberland Valley Retina Consultants PC

    Hagerstown, Maryland, 21740, United States

  • Deep Blue Retina Clinical Research

    Southaven, Mississippi, 38671, United States

  • Duke Eye Center

    Durham, North Carolina, 27705, United States

  • Emanuelli Research and Development Center LLC

    Arecibo, 00612, Puerto Rico

  • Erie Retinal Surgery

    Erie, Pennsylvania, 16507, United States

  • Eye Associates of New Mexico

    Albuquerque, New Mexico, 87109, United States

  • Eye Care Center of Northern Colorado PC

    Longmont, Colorado, 80503, United States

  • EyeHealth Northwest

    Portland, Oregon, 97224, United States

  • Florida Eye Associates

    Melbourne, Florida, 32901, United States

  • Fondazione G.B. Bietti Per Lo Sudio E La Ricerca In Oftalmologia-Presidio Ospedaliero Britannico

    Rome, Lazio, Italy

  • Foundation for Vision Research

    Grand Rapids, Michigan, 49546, United States

  • Hadassah Medical Center

    Jerusalem, 91120, Israel

  • Hôpital de La Croix Rousse

    Lyon, 69004, France

  • Marsden Eye Specialists

    Parramatta, New South Wales, 2150, Australia

  • Medizinische Hochschule Hannover, Innere Abteilung/Pneumologie

    Hanover, 30625, Germany

  • National Ophthalmic Research Institute

    Fort Myers, Florida, 33912, United States

  • New England Retina Consultants

    Springfield, Massachusetts, 01107, United States

  • Northern California Retina Vitreous Associates

    Mountain View, California, 94040, United States

  • Ophthalmic Consultants of Long Island

    Rockville Centre, New York, 11570, United States

  • Ospedale S. Giuseppe Multimedica

    Milan, Lombardy, 20123, Italy

  • Ospedale San Raffaele S.r.l. - PPDS

    Milan, Lombardy, 20132, Italy

  • Palmetto Retina Center, LLC

    West Columbia, South Carolina, 29169, United States

  • Rabin Medical Center

    Petah Tikva, 49100, Israel

  • Raj K. Maturi, MD PC

    Indianapolis, Indiana, 46290, United States

  • Rambam Medical Center - PPDS

    Haifa, 3109600, Israel

  • Rand Eye Institute

    Deerfield Beach, Florida, 33064, United States

  • Retina Consultants of Orange County

    Fullerton, California, 92835, United States

  • Retina Consultants of Texas

    Bellaire, Texas, 77401, United States

  • Retina Consultants, San Diego

    Poway, California, 92064, United States

  • Retina Foundation of the Southwest

    Dallas, Texas, 75231, United States

  • Retina Partners of Northwest Arkansas, PLLC

    Springdale, Arkansas, 72764, United States

  • Retina Specialists

    DeSoto, Texas, 75115, United States

  • Retina Vitreous Center

    Edmond, Oklahoma, 73013, United States

  • Retinal Consultants Medical Group

    Sacramento, California, 95841-2013, United States

  • Rocky Mountain Retina

    Salt Lake City, Utah, 84107, United States

  • San Antonio Eye Center

    San Antonio, Texas, 78215, United States

  • Scheie Eye Institute

    Philadelphia, Pennsylvania, 19104, United States

  • Sierra Eye Associates

    Reno, Nevada, 89502, United States

  • Southeast Retina Center

    Augusta, Georgia, 30909, United States

  • Southwest Retina Consultants

    Durango, Colorado, 81303, United States

  • Spokane Eye Clinical Research

    Spokane, Washington, 99204, United States

  • Sydney Retina Clinic and Day Surgery

    Sydney, New South Wales, 2000, Australia

  • Tel Aviv Sourasky Medical Center PPDS

    Jerusalem, 90000, Israel

  • Tennessee Retina PC

    Nashville, Tennessee, 37203, United States

  • The Lions Eye Institute

    Nedlands, Western Australia, 6009, Australia

  • The Retina Partners

    Encino, California, 91436-2018, United States

  • UC Davis Eye Center

    Sacramento, California, 95817, United States

  • Universitatsklinikum Leipzig

    Leipzig, 04103, Germany

  • Universitatsklinikum Munster

    Münster, 48149, Germany

  • Universitatsklinikum Tubingen

    Tübingen, 72076, Germany

  • University Medicine Gottingen Germany

    Göttingen, 37075, Germany

  • University Retina and Macula Associates, PC

    Oak Forest, Illinois, 60452, United States

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin, 53705-2275, United States

  • Universitätsklinikum Bonn

    Bonn, 53127, Germany

  • Universitätsklinikum Freiburg

    Freiburg im Breisgau, 79106, Germany

  • Vitreous Retina Macula Consultants of New York

    New York, New York, 10022, United States

  • W Texas Retina Consultants PA

    Abilene, Texas, 79606, United States

  • Wagner Kapoor Institute

    Norfolk, Virginia, 23502, United States

  • Wolfe Eye Clinic

    West Des Moines, Iowa, 50266, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.