Changhai Hospital

This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see…

This study compares two approaches for people with mild-to-moderate carotid artery stenosis (narrowing of the neck arteries): a standard statin regimen versus a statin plus a PCSK9 inhibitor (evolocumab) given as biweekly injections. The main goal is to see whether the combinatio…

This study tests whether adding an immunotherapy drug (toripalimab) to standard BCG therapy can help people with high-risk bladder cancer avoid bladder removal. About 31 participants will receive the combination after surgery. The main goal is to see if the cancer disappears with…

This early-phase trial tests a new treatment called KN5501, which uses specially engineered immune cells (CAR NK cells) to target and destroy harmful B cells in people with relapsed or refractory immune nephropathy, a kidney disease caused by the immune system attacking the kidne…

This phase 2 trial is testing whether the drug hetrombopag can prevent chemotherapy-induced thrombocytopenia (low platelet counts) in people with gastrointestinal tumors. The study will enroll 40 patients who had low platelets in a previous chemo cycle. Participants take hetrombo…

This early-phase study tests a new type of CAR-T cell therapy (called KN3601) for people with severe autoimmune diseases like lupus, scleroderma, Sjögren's syndrome, rheumatoid arthritis, and vasculitis that haven't responded to standard treatments. The therapy uses specially eng…

This early-stage study tests a new treatment called CAR-NK cells (CL-NK-003) in 9 people with advanced pancreatic cancer that has not responded to standard therapies. The main goal is to check safety and find the right dose. Researchers will also watch for signs that the treatmen…

This early-phase study tests a new treatment called anti-CD19/BCMA universal CAR T cells (KN3601) for people with relapsed or refractory immune-mediated kidney disease. The therapy involves collecting a patient's immune cells, engineering them to target and destroy harmful B cell…

This trial tests a personalized cell therapy for advanced pancreatic cancer. Patients receive their own immune cells that have been engineered to recognize and attack cancer cells with a specific mutation (KRAS G12V). The study enrolls 30 people whose tumors carry this mutation a…

This study tests a new approach to treat high-risk bladder cancer without removing the bladder. Doctors will first remove the tumor through the urethra, then freeze the tumor base with a special balloon, followed by immunotherapy and low-dose chemotherapy. The goal is to see if t…

This study tests whether transplanting healthy gut bacteria (FMT) can reduce infections in people with moderate to severe acute pancreatitis. 80 participants will receive either FMT or a placebo through a feeding tube for five days. The goal is to see if FMT lowers the risk of se…

This study tests an artificial intelligence (AI) system that analyzes contrast-enhanced CT scans to help diagnose and manage pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitoring, or routine follow-up. Researchers will…

This trial tests whether making a small opening in the sac around the heart (posterior pericardiotomy) during heart surgery can prevent a common complication called atrial fibrillation. About 650 adults in China having surgery on the heart's valves, coronary arteries, or aorta wi…

This study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from healthy donors — can prevent infections in people with moderately severe or severe acute pancreatitis. About 150 adults will receive either FMT liquid or a placebo through a feeding t…

This study tests whether giving extra IV fluids along with a standard anti-inflammatory suppository can better prevent pancreatitis after a procedure to break up pancreatic stones. About 1250 adults with chronic pancreatitis will be randomly assigned to receive either the combina…

This study compares a low dose (50 mg) versus the standard dose (100 mg) of indomethacin given rectally before ERCP to prevent post-procedure pancreatitis. About 1,366 adults undergoing ERCP will be randomly assigned to one of the two doses in a double-blind fashion. The goal is …

This study tests whether a pre-packaged low-residue diet (Maifu Changqing®) helps people with inflammatory bowel disease (IBD) prepare for colonoscopy more comfortably and effectively. About 500 adults with IBD will be enrolled across multiple hospitals in China. The goal is to s…

This study tests whether a pre-packaged low-residue nutrition formula (Maifu Changqing®) can improve bowel cleanliness and comfort during colonoscopy preparation for 1,000 adults with inflammatory bowel disease (IBD). Participants will be randomly assigned to receive either the s…

This study involves 1,000 adults with inflammatory bowel disease (IBD) who need a colonoscopy. Researchers want to see how well current bowel preparation methods work and what factors lead to poor preparation. The goal is to create a tool that predicts which patients might have t…

This study is gathering images from special cameras and CT scans, along with lab results, to create a database for early upper gastrointestinal cancers and precancerous conditions. About 500 adults who need certain procedures will take part. The goal is to help doctors better rec…