Centre Antoine Lacassagne

This study tested a two-step treatment for adults aged 65 to 80 with a type of lymphoma. First, they received standard chemotherapy plus a targeted antibody (rituximab). Then, they got more rituximab and a radioactive antibody (Y90 ibritumomab) to kill remaining cancer cells. The…

This study tested three different nutrition plans given through a feeding tube to see which one best prevents infections after surgery for head and neck cancer. 311 patients took part. The goal was to find the most effective way to support recovery and reduce complications.

This early-phase study tested a combination of three drugs (gemcitabine, capecitabine, and erlotinib) in 30 people with advanced pancreatic cancer that had already been treated. The main goal was to find the safest dose and understand side effects. This is not a cure, but aims to…

This study looked at giving a precise, high-dose radiation treatment called CyberKnife after standard chemotherapy and radiation for people with stage III non-small cell lung cancer that could not be removed with surgery. The goal was to find the safest highest dose of CyberKnife…

This study tested a single, high-dose radiation treatment for men with low-risk prostate cancer. The goal was to see how well the body tolerates this one-time procedure by tracking side effects in the urinary and digestive systems for 6 months. 35 men participated, and the treatm…

This early-phase study tested a new approach for women with breast cancer who cannot have breast-conserving surgery. It combined a short course of high-dose radiation (Cyberknife) with standard chemotherapy drugs. The main goal was to find the safest radiation dose and see how we…

This study tested a new way to give radiation therapy during breast cancer surgery, called intraoperative radiotherapy. It included 28 women aged 60 or older with early-stage, low-risk breast cancer. The goal was to see if the technique could deliver the right dose of radiation t…

This study tested a new way to give an extra dose of radiation (a boost) to the tumor site after standard breast radiation. Instead of multiple sessions, the CyberKnife machine delivered a single high dose very precisely, aiming to reduce skin damage and improve cosmetic results.…

This study tested a combination of chemotherapy, radiation, and a targeted drug called cetuximab in 53 patients with head and neck cancer who had a high risk of the cancer coming back after surgery. The goal was to see if this triple therapy could keep the cancer from returning f…

This study tested whether a special PET scan called 18F-FDOPA can help doctors make better treatment decisions for people with brain tumors (gliomas or metastases) when standard MRI results are unclear. 85 patients whose MRI scans left doctors unsure about the next step received …

This study looked at how well MRI scans can measure the size of ductal carcinoma in situ (DCIS), a very early form of breast cancer. Forty women with DCIS had an MRI before surgery, and the MRI results were compared to the actual tumor size found during surgery. The goal was to s…

This study looked at 100 people with advanced lung cancer or melanoma who were getting immunotherapy. Researchers used a special PET scan to see if they could tell the difference between real tumor growth and inflammation that looks like growth. The goal was to improve how doctor…

This study tested two ways to mark non-palpable breast tumors before surgery: a tiny iodine seed versus a standard metal wire. 350 women with early breast cancer took part. The goal was to see if the seed method leads to cleaner surgical margins and less pain. Results help doctor…

This study looked at whether two phone calls during the first three rounds of chemotherapy could improve the emotional well-being of patients with breast or colon cancer. 274 patients were randomly assigned to receive either standard care or additional phone support. The goal was…

This study tested whether an expensive PET scan called 18F-FDOPA helps doctors choose better treatments for people with high-grade gliomas, a type of aggressive brain tumor. About 110 patients whose cases were discussed by a team of experts were included. The main goal was to see…

This study looked at 422 breast cancer patients to understand how their knowledge of exercise benefits, their current activity level, and their fatigue affect their beliefs about physical activity and their desire to be active. All participants were undergoing chemotherapy and we…

This study examined 52 breast cancer tumor samples and some blood samples to find chemical markers (metabolites) that might help understand different types of breast cancer better. The goal was to learn more about how cancer cells use energy and to find possible targets for futur…

This study analyzed blood samples from 49 women with metastatic breast cancer to find genetic markers linked to how they respond to trastuzumab (Herceptin). The goal was to better understand side effects like heart toxicity and allergic reactions, as well as treatment effectivene…

This study followed 240 adults with head and neck cancer for 18 months after their first treatment. Researchers used questionnaires and doctor evaluations to track how often and how severely swallowing problems occurred, and how long they lasted. The goal was to better understand…

This study looked at how cancer treatment changes patients' sense of taste and smell, and how that affects their ability to follow a healthy Mediterranean diet. Researchers tracked 116 patients before and after 9 weeks of treatment. The goal is to understand these changes so bett…

This study looked at whether a genetic deficiency (DPD deficiency) can predict severe side effects from the chemotherapy drug capecitabine in women with metastatic breast cancer. Researchers analyzed blood samples from 303 participants to see if those with the deficiency experien…

This study followed 76 adults over age 70 with solid tumors who were starting chemotherapy for the first time. Researchers used questionnaires to measure quality of life, daily activities, and mental function. The goal was to learn how to better tailor cancer treatment and suppor…

This study looked at 160 people with head and neck cancer who needed a scope exam of their throat. Researchers compared standard oxygen therapy with a high-flow system that delivers warm, moist oxygen at high rates. The goal was to see which method better prevents drops in oxygen…

This study looked at how common iron deficiency is in 480 cancer patients starting chemotherapy. The goal was to find out how many patients might benefit from iron injections. Researchers measured iron levels using blood tests to better understand and manage anemia in cancer care…

This study looked at 700 cancer patients to understand how often they develop dangerous blood clots (like deep vein thrombosis or pulmonary embolism). It focused on patients who already take blood thinners or have low platelet counts, which can complicate treatment. The goal was …

This study aimed to find out how many cancer patients had been infected with COVID-19, including those without symptoms. Researchers used a rapid blood test to check for antibodies in 214 adults receiving cancer treatment. The goal was to better understand infection risks and hel…

This study looked at whether having an extra talk with a radiotherapy technician helps cancer patients get better information about their treatment. Over 300 adults with various cancers took part. The goal was to see if this extra chat reduces anxiety and helps patients feel more…