Centre Antoine Lacassagne

This early-stage study tested a combination of three drugs—gemcitabine, capecitabine, and erlotinib—in patients with advanced pancreatic cancer that had worsened after initial treatment. The main goal was to find the highest dose patients could tolerate without severe side effect…

This early-stage study tested a new approach for treating breast cancer before surgery. It combined a shorter, more intense course of targeted radiation (CyberKnife) with chemotherapy drugs. The main goal was to find the safest and most effective radiation dose to shrink tumors, …

This study tested a new device that delivers a concentrated dose of radiation directly to the tumor site during breast cancer surgery. It aimed to see if this faster, single-dose method was a practical alternative to the standard weeks-long course of whole-breast radiation. The t…

This study tested a combination treatment to prevent cancer from coming back in patients with high-risk head and neck cancer who had already undergone surgery. It combined radiation therapy, a standard chemotherapy drug (cisplatin), and a newer targeted drug (cetuximab). The main…

This study compared two ways of giving oxygen to patients under anesthesia for a common diagnostic procedure for head and neck cancer. Researchers tested a newer, high-flow oxygen system against the standard method to see which one better maintains safe oxygen levels and reduces …

This study tested a two-step treatment for older adults (65-80) newly diagnosed with a type of aggressive lymphoma. First, patients received a standard chemotherapy regimen. If they responded, they then received a second, targeted radiation treatment designed to seek out and kill…

This study tested whether a single, precise radiation treatment using CyberKnife technology could replace multiple standard radiation sessions given after lumpectomy for early-stage breast cancer. Researchers wanted to see if this approach could reduce skin redness, swelling, and…

This study tested a new way to mark small, hidden breast tumors before surgery. It compared a tiny radioactive seed implanted near the tumor to the standard method of using a metal wire that sticks out of the breast. The goal was to see if the seed method was as good or better at…

This study tested whether MRI scans could more accurately measure the size of a very early form of breast cancer called DCIS. It involved 40 women with DCIS who received both an MRI and a standard mammogram. The goal was to see if MRI could give surgeons a clearer picture of the …

This study tested a special type of PET scan to see if it could solve a common problem in cancer immunotherapy. For patients with advanced lung cancer or melanoma, the scan aimed to tell the difference between the cancer actually growing versus harmless inflammation that just loo…

This study tested whether giving patients a special 'immunonutrition' formula before and after surgery could help prevent infections. It involved 311 people with head and neck cancer who were scheduled for surgery. Researchers compared three different nutrition plans to see which…

This study followed 76 patients over 70 years old with solid tumors to understand how their quality of life changes during chemotherapy. Researchers used standard geriatric questionnaires to measure daily functioning and mental state. The goal was to learn how to better tailor ca…

This study aimed to better understand and track blood clots in people with cancer, as clots are a leading cause of death for them. Researchers observed 700 hospitalized cancer patients, some already on blood thinners, to see how often clots occurred and how they affected survival…

This study looked at whether having a special information session with a radiation therapist helps cancer patients feel better informed and less anxious during radiotherapy treatment. Researchers compared patients who received standard information with those who had additional co…

This study aimed to understand how often and how severely swallowing problems occur in people being treated for head and neck cancer. Researchers followed 240 patients from diagnosis through 18 months after their first treatment, using questionnaires and clinical exams. The goal …

This study aimed to better understand the biology of different types of breast cancer by analyzing the small molecules (metabolites) inside tumor cells. Researchers examined 52 frozen tumor samples from a biobank to look for unique metabolic patterns that could serve as future bi…

This study aimed to understand what breast cancer patients think about physical activity during chemotherapy and whether watching motivational videos from other patients could encourage them to exercise. Researchers surveyed 422 sedentary breast cancer patients about their belief…

This study aimed to understand how common COVID-19 infections were among cancer patients during the pandemic. Researchers tested 214 cancer patients using a rapid finger-prick blood test that looks for COVID-19 antibodies. The goal was to gather data on infection rates, including…