Centre Antoine Lacassagne

This study tests a new two-drug combination for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to initial treatment. The drugs target a genetic change (FLT3 mutation) found in some AML patients. The goal is to see if the combinatio…

This study tests a combination of two drugs, pazopanib and temozolomide, in adults with newly diagnosed glioblastoma, a fast-growing brain tumor. Participants take the drugs after surgery and standard chemoradiation. The goal is to find the safest dose of pazopanib and see how we…

This study aimed to test the safety and effectiveness of adding the drug ribociclib to standard hormone therapy and radiation for women aged 70 and older with a certain type of breast cancer. The participants would have been newly diagnosed and unable or unwilling to have surgery…

This study tests whether a special type of internal radiation (contact X-ray brachytherapy) is better than standard external radiation at helping people with early-stage rectal cancer avoid surgery. About 148 adults with small, early rectal tumors will receive standard chemoradia…

This study compares two imaging methods to see how well brain blood vessels respond to a drug called acetazolamide. The PET scan method is being tested against the standard scintigraphy method to see if it works just as well. Nineteen adults with narrowed brain arteries (over 70%…