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New radiation technique may help rectal cancer patients keep their rectum

NCT ID NCT02505750

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 25 times

Summary

This study tests whether a special type of internal radiation (contact X-ray brachytherapy) is better than standard external radiation at helping people with early-stage rectal cancer avoid surgery. About 148 adults with small, early rectal tumors will receive standard chemoradiation followed by one of the two boost radiation methods. The goal is to see if more patients can keep their rectum and avoid a permanent colostomy three years after treatment.

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Contacts and locations

Locations

  • CHRU Besançon

    Besançon, Bourgogne-Franche-Comté, 25030, France

  • Centre Antoine Lacassagne

    Nice, 06189, France

  • Centre Jean Godinot

    Reims, Champagne-Ardenne, 51726, France

  • Centre Léon Bérard

    Lyon, 69008, France

  • Centre d'oncologie et de radiothérapie Mâcon

    Mâcon, 71000, France

  • Centre de radiothérapie Bayard

    Villeurbanne, 69100, France

  • Christie Hospital

    Manchester, M204BX, United Kingdom

  • Clatterbridge Cancer Centre NHS Foundation Trust

    Liverpool, L9 7BA, United Kingdom

  • Clinique Charcot

    Sainte-Foy-lès-Lyon, 69110, France

  • Clinique de la Sauvegarde

    Lyon, Auvergne-Rhône-Alpes, 69009, France

  • Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud

    Pierre-Bénite, 69495, France

  • Hôpital de la Croix Rouge Française - Centre de Radiothérapie St Louis

    Toulon, 83100, France

  • Hôpitaux Universitaires de Genève

    Geneva, CG-1211, Switzerland

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut de Cancérologie Lucien Neuwirth

    Saint-Priest-en-Jarez, 42270, France

  • Royal Surrey County Hospital

    Guildford, GU2 7XX, United Kingdom

  • Spire Hull and East Riding Hospital

    Hull, HU10 7AZ, United Kingdom

  • University Hospital

    Nottingham, NG5 8RX, United Kingdom

Conditions

Explore the condition pages connected to this study.