Alliance For Clinical Trials In Oncology

This study tests whether adding a precise type of radiation therapy (I²-PORT) after surgery can lower the chance of cancer coming back in people with non-small cell lung cancer who still have cancer in their lymph nodes. About 164 adults will be randomly assigned to receive eithe…

This study is for men with advanced, hormone-resistant prostate cancer that has spread. It tests whether giving the targeted radiation drug lutetium-177 PSMA less often, based on how the cancer responds, can improve quality of life without shortening survival. About 1,500 partici…

This phase 3 trial tests whether adding sonrotoclax to zanubrutinib for a fixed time works better than taking zanubrutinib alone long-term in older adults with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. About 466 participants will be randomly assigned t…

This study tests whether adding the targeted drug vorasidenib to standard chemotherapy (temozolomide) after radiation can slow tumor growth better than chemo alone in people with a specific, aggressive brain tumor (grade 3 IDH-mutated astrocytoma). About 408 newly diagnosed patie…

This study looks at the best way to inform close relatives (parents, siblings, children) of people newly diagnosed with colorectal cancer about their possible genetic risk. It compares having the patient share the information versus having a healthcare provider do it. The goal is…