Alliance For Clinical Trials In Oncology

This study is testing if adding a high daily dose of vitamin D3 to standard chemotherapy helps people with advanced colorectal cancer that has spread. Researchers want to see if the vitamin D helps shrink tumors or keeps the cancer from growing for a longer time compared to stand…

This study is for people whose advanced pancreatic cancer has spread and has a specific genetic change (BRCA1, BRCA2, or PALB2 mutation). It compares a new three-drug chemotherapy combination (NABPLAGEM) against the current standard two-drug combination. The goal is to see if add…

This study aims to find out which of two chemotherapy drug combinations works better with radiation therapy to control a specific genetic type of brain tumor (glioma). It is for adults newly diagnosed with anaplastic glioma or high-risk low-grade glioma that has a particular gene…

This study is comparing two different treatment strategies for a rare type of brain cancer called primary CNS B-cell lymphoma. It aims to see if a more intensive approach using high-dose chemotherapy followed by a stem cell transplant is more effective at keeping the cancer from …

This study is testing whether extra support helps breast cancer patients take their daily hormone therapy pills correctly. Over 1,100 women who have finished their main cancer treatment will receive text message reminders, phone counseling, or both, and be compared to those recei…

This study is testing whether adding the drug cetuximab to avelumab works better than avelumab alone to control advanced skin cancer that has spread. It will involve about 60 adults with metastatic or inoperable cutaneous squamous cell carcinoma. The main goal is to see which tre…

This study is for people with a specific type of stage II or III colon cancer who have already had surgery and chemotherapy. It tests whether adding a new, targeted two-drug treatment after the standard care is better at keeping the cancer from coming back, compared to just watch…

This study is for people with advanced bladder cancer who have already had about a year of immunotherapy. It compares two approaches: continuing the immunotherapy treatment versus stopping it. The main goal is to see if stopping treatment leads to similar survival rates while pot…

This study aims to see if adding one of two new drugs (duvelisib or CC-486) to a standard chemotherapy regimen works better for treating newly diagnosed peripheral T-cell lymphoma, a rare and aggressive blood cancer. It will compare the complete remission rates and side effects b…

This large study is testing whether a lower dose of the hormone-blocking drug tamoxifen works as well as standard hormone therapy for preventing breast cancer from returning. It involves over 1,100 postmenopausal women with early-stage, low-risk breast cancer. The goal is to see …

This study tests whether using genetic testing to match patients with specific drugs can help control cancer that has spread to the brain. It is for adults with solid tumors (like lung or breast cancer) that have spread to the brain and have certain genetic changes. Patients rece…

This large Phase 3 trial is comparing two different timing strategies for chemotherapy in people with pancreatic cancer that can be surgically removed. It tests whether giving strong chemotherapy both before and after surgery leads to better survival and cancer control than the s…

This study is for adults with advanced dedifferentiated liposarcoma, a rare and aggressive cancer. It compares a standard cancer drug (palbociclib) alone versus the same drug combined with an immunotherapy drug (cemiplimab). The goal is to see if the two-drug combination is more …

This study is testing if combining two drugs, sorafenib and everolimus, works better than sorafenib alone to control a rare, aggressive form of thyroid cancer that no longer responds to standard radioactive iodine treatment. The trial will enroll about 35 adults to see if the dru…

This study is testing if the drug enzalutamide can shrink tumors in people with advanced salivary gland cancer that has a specific marker (androgen receptor). The trial will enroll about 46 patients to see if the treatment is effective and safe. Enzalutamide is already approved f…

This study is testing if adding a drug called rucaparib to standard treatment (enzalutamide) works better for men whose prostate cancer has spread and stopped responding to hormone therapy. The goal is to see if the combination helps patients live longer or keeps their cancer fro…

This trial is testing whether a three-drug chemotherapy combination (FOLFIRINOX) works better than the standard two-drug combinations (FOLFOX or CAPOX) for patients with locally advanced rectal cancer. All patients first receive radiation with chemo, then are randomly assigned to…

This large study is testing whether adding the drug tucatinib to standard treatment (T-DM1) works better at preventing breast cancer from coming back. It is for people with a specific type of high-risk, HER2-positive breast cancer who still have some cancer cells after their init…

This large study compares different hormone therapy approaches given before surgery to shrink breast cancer tumors in postmenopausal women. Researchers are testing whether newer drug combinations work better than the current standard treatment at controlling cancer growth and pre…

This large Phase 3 trial is testing whether a surgical technique called axillary reverse mapping can prevent lymphedema—painful arm swelling—in breast cancer patients having lymph node removal surgery. Researchers are comparing patients who receive the new mapping procedure durin…

This large, Phase 3 trial aims to see if adding a targeted drug called inotuzumab ozogamicin to standard chemotherapy works better for young adults (ages 18-39) newly diagnosed with a fast-growing blood cancer called B-cell acute lymphoblastic leukemia (ALL). The main goal is to …

This study is testing whether men with advanced prostate cancer that has spread can safely take a break from hormone-blocking medications when their cancer responds exceptionally well to treatment. The trial involves 79 men who have been on strong hormone therapy for 18-24 months…

This large study is comparing two different schedules of radiation therapy given after mastectomy to prevent breast cancer from coming back. It is testing if a shorter 3-4 week schedule is as safe for breast reconstruction and works as well as the standard 5-6 week schedule. The …

This study compares two ways of delivering targeted radiation after surgery to remove cancer that has spread to the brain. It tests whether giving one high-dose treatment is as good as, or worse than, giving several smaller doses over a few days. The goal is to see which method b…

This study is testing if the drug duloxetine can prevent or reduce nerve pain, tingling, and numbness caused by a chemotherapy drug called oxaliplatin. It involves 220 people with stage II or III colorectal cancer who are scheduled to receive oxaliplatin. The trial will compare d…

This trial is testing whether a substance called GM1 can prevent or reduce nerve damage (neuropathy) caused by paclitaxel chemotherapy. It involves about 98 people with metastatic breast cancer who are receiving this specific chemo. Participants are randomly assigned to receive e…

This study is testing a special guide, called a decision aid, designed to help people newly diagnosed with early-stage breast cancer be more involved in choosing between surgery options like lumpectomy or mastectomy. It involves over 600 patients across 10 clinics and focuses on …