Alliance For Clinical Trials In Oncology

This study looked at how well older adults (70+) with advanced, hormone-positive breast cancer tolerate a combination of palbociclib plus either letrozole or fulvestrant. The goal was to understand side effects and find factors that might predict who handles treatment better. 93 …

This study tested a combination of two drugs, sorafenib and bevacizumab, in 83 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The goal was to see if the combination could slow or stop tumor growth. Participants received both …

This study tested a combination of chemotherapy drugs in 318 adolescents and young adults (ages not specified) with newly diagnosed acute lymphoblastic leukemia (ALL). The goal was to see how well the treatment worked at killing cancer cells and stopping the disease from coming b…

This study looked at whether adding the drug celecoxib (often used for arthritis) to standard chemotherapy helps prevent colon cancer from coming back after surgery. About 2,500 patients with stage III colon cancer took part. They received either 6 or 12 rounds of chemo, plus eit…

This study tested whether giving the drug bortezomib after intensive chemotherapy, immunotherapy, and a stem cell transplant could help keep mantle cell lymphoma from coming back. 151 patients took part. The goal was to see if this approach improved how long people lived without …

This study compared two types of surgery for people with small (≤2 cm) early-stage lung cancer: removing the entire lobe (lobectomy) versus removing only the tumor and a small margin (sublobar resection). The goal was to see if the less invasive approach works just as well with f…

This study looked at whether adding physical therapy to education helps prevent lymphedema (arm swelling) in women treated for breast cancer. Women with stage I to III breast cancer who had lymph nodes removed from their armpit took part. The goal was to see if a personalized phy…

This study looked at whether having a breast MRI before surgery helps women with early-stage breast cancer get better surgical results. About 317 women with certain types of breast cancer took part. The goal was to see if the MRI could reduce the need for repeat surgeries and imp…