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Double-Drug attack on prostate cancer shows promise in early trial

NCT ID NCT04455750

Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase III trial tests whether adding rucaparib to standard enzalutamide therapy helps men with metastatic castration-resistant prostate cancer live longer or delay cancer growth. The study involves 61 participants and compares the combination against enzalutamide alone. Researchers are also looking at whether certain DNA repair gene mutations affect how well the treatment works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
enzalutamide and rucaparib
What this could lead to
If successful, this combination could help men with advanced prostate cancer live longer and keep their cancer from growing or spreading for a longer time.
What could go wrong
This is an early-phase trial with only 61 participants, so results may not apply to everyone. The combination may cause more side effects than enzalutamide alone, and it's not yet proven to be better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

61 people

The number who actually took part.

Started

Oct 2021

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologic/cytologic documentation of prostate adenocarcinoma * Adequate archival tumor specimen or archival slides must be available to be tested as part of the trial screening (most recent metastatic site biopsy preferred, but primary prostate biopsy allowed if metastatic biopsy is not available or inadequate. A new biopsy is not required for pre-registration in the trial as long as sufficient archival tissue is available). Due to significant variability between tests, results from an existing targeted next-generation exome sequencing test may not be used for this trial * Progressive disease must be demonstrated at study entry while the patient is on continuous androgen deprivation therapy (ADT) or status post orchiectomy. Progressive disease is defined as one or more of the following criteria: * PSA progression, defined by at least 2 consecutive rising PSA values at a minimum of 1-week intervals with the most recent PSA value being 1.0 ng/mL or higher, if confirmed PSA rise is the only indication of progression. Patients who received an anti-androgen must have PSA progression after withdrawal of anti-androgen therapy (\>=4 weeks since last flutamide, bicalutamide or nilutamide, apalutamide or darolutamide) * Radiographic progression per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 for soft tissue lesions * Bone metastasis progression per Prostate Cancer Working Group 3 (PCWG3) criteria * Measurable or non-measurable metastatic disease * No prior therapy for metastatic castration-resistant prostate cancer, defined as a treatment given for prostate cancer with radiographically-detectable metastasis and a serum testosterone level less than 50 ng/dl (1.73 nmol/L) at the time of registration * \>= 2 weeks or 5 half-lives (whichever is shorter) since prior therapy with flutamide, dutasteride, bicalutamide, niltamide, finasteride, aminoglutethimide, estrogens, cytoproterone, chemotherapy, abiraterone, apalutamide, or darolutamide * \>= 4 weeks or 5 half-lives (whichever is shorter) since any prior investigational therapy * \>= 4 weeks since a major surgery or radiation * No prior therapy with enzalutamide, rucaparib or any other PARP inhibitor, or platinum chemotherapy * Prior docetaxel and/or novel anti-androgen use is allowed only if given in the hormone-sensitive non-metastatic or metastatic, or castration-resistant non-metastatic disease setting * Patient must have discontinued all previous treatments for cancer (except ADT and bone anti-responsive therapies such as denosumab or zoledronic acid) and must have recovered from all acute side effects of prior therapy or surgical procedures to =\< grade 1 or baseline prior to randomization, with the exception of fatigue, alopecia or peripheral neuropathy * Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Absolute neutrophil count (ANC) \>= 1,500/mm\^3 * Platelet count \>= 100,000/mm\^3 * Hemoglobin \>= 10 g/dL * Serum testosterone =\< 50 ng/dl (=\< 1.73 nmol/L) * Serum creatinine =\< 1.5 x upper limit of normal (ULN) * Total bilirubin =\< 1.5 x upper limit of normal (ULN) * Aspartate transaminase (AST)/alanine transferase (ALT) =\< 2.5 x upper limit of normal (ULN) * No clinically suspected central nervous system (CNS) (leptomeningeal or parenchymal) metastases. Patients with a history of CNS metastasis(s) will be allowed as long (1) as the metastatic site(s) were adequately treated as demonstrated by clinical and radiographic improvement, AND (2) the patient has recovered from the intervention (no residual adverse events \> Common Terminology Criteria for Adverse Events \[CTCAE\] grade 1), AND (3) the patient has remained without occurrence of new or worsening CNS symptoms for a period of 28 days prior to pre-registration * No known or suspected history of cytopenia (low white blood cell \[WBC\], hemoglobin or platelet count) of greater than 3 months duration with an unknown cause, myelodysplastic syndrome, or hematologic malignancies * No blood product transfusion, granulocyte/granulocyte-macrophage-colony stimulating factor (G-CSF/GM-CSF), or erythropoietin/thrombopoietin use within 14 days of pre-registration * No history of syncope of cardiovascular etiology, uncontrolled cardiac arrhythmia, history of Mobitz II second degree or third degree heart block without a permanent pacemaker in place, myocardial ischemia or infarction, severe or unstable angina, New York Heart Association (NYHA) class II to IV heart failure, or stroke/transient ischemic attack (TIA) within the past 3 months * No history of seizure or any condition that may increase the patient's seizure risk (e.g., prior cortical stroke, significant brain trauma) within 2 years * No clinically active or chronic liver disease resulting in moderate/severe hepatic impairment (Child-Pugh class B or C), ascites, coagulopathy or bleeding due to liver dysfunction * No clinical, laboratory or radiographic evidence of an active bacterial, fungal, or viral infection requiring treatment at the time of registration * No planned palliative procedures for alleviation of bone pain such as radiation therapy or surgery * No untreated spinal cord compression or evidence of spinal metastases with a risk of impending fracture or spinal cord compression * No known or suspected contraindications or hypersensitivity to enzalutamide, rucaparib, or to any of the excipients * No known or suspected gastrointestinal disorder affecting absorption of oral medications * No prior malignancy for which the last treatment was given within the past 2 years, or any active concurrent malignancy with the exception of non-melanomatous localized skin cancers (such as squamous or basal cell carcinoma of the skin) * Any concomitant medications that are strong inhibitors of CYP2C8 or inducers of CYP3A4 cytochrome enzymes must be discontinued prior to registration. Dose adjustments per Food and Drug Administration (FDA) label or clinical judgement should be considered for any concomitant medications that are moderate inhibitors of CYP2C8 or inducers of CYP3A4 cytochrome enzymes * Any concomitant medications that are substrates of CYP3A4, CYP2C9 and CYP2C19 cytochrome enzymes should be monitored closely per clinical judgement of the treating physician

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Castration-resistant prostate carcinoma Metastatic prostate adenocarcinoma Stage IV prostate cancer ajcc V8 Stage IVA prostate cancer ajcc V8 Stage IVB prostate cancer ajcc V8

Contacts and locations

Locations

  • 21st Century Oncology-Pontiac

    Pontiac, Michigan, 48341, United States

  • Academic Hematology Oncology Specialists

    Grosse Pointe Woods, Michigan, 48236, United States

  • Advanced Breast Care Center PLLC

    Warren, Michigan, 48088, United States

  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois, 60657, United States

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068, United States

  • Alaska Breast Care and Surgery LLC

    Anchorage, Alaska, 99508, United States

  • Alaska Oncology and Hematology LLC

    Anchorage, Alaska, 99508, United States

  • Alaska Women's Cancer Care

    Anchorage, Alaska, 99508, United States

  • Alegent Health Bergan Mercy Medical Center

    Omaha, Nebraska, 68124, United States

  • Alegent Health Immanuel Medical Center

    Omaha, Nebraska, 68122, United States

  • Alegent Health Lakeside Hospital

    Omaha, Nebraska, 68130, United States

  • Alegent Health Mercy Hospital

    Council Bluffs, Iowa, 51503, United States

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, 98508, United States

  • Anchorage Oncology Centre

    Anchorage, Alaska, 99508, United States

  • Anchorage Radiation Therapy Center

    Anchorage, Alaska, 99504, United States

  • Armes Family Cancer Center

    Findlay, Ohio, 45840, United States

  • Ascension Borgess Cancer Center

    Kalamazoo, Michigan, 49009, United States

  • Ascension Saint John Hospital

    Detroit, Michigan, 48236, United States

  • Ascension Saint Joseph Hospital

    Tawas City, Michigan, 48764, United States

  • Ascension Saint Mary's Hospital

    Saginaw, Michigan, 48601, United States

  • Augusta Oncology Associates PC-D'Antignac

    Augusta, Georgia, 30901, United States

  • Augusta Oncology Associates PC-Wheeler

    Augusta, Georgia, 30909, United States

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin, 54143, United States

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin, 54311, United States

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin, 53024, United States

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin, 53142, United States

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin, 53209, United States

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin, 53226, United States

  • Aurora Cancer Care-Racine

    Racine, Wisconsin, 53406, United States

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin, 53105, United States

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin, 53022, United States

  • Aurora Medical Center in Summit

    Summit, Wisconsin, 53066, United States

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin, 53233, United States

  • Aurora West Allis Medical Center

    West Allis, Wisconsin, 53227, United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • Avera Cancer Institute at Yankton

    Yankton, South Dakota, 57078, United States

  • Avera Cancer Institute-Aberdeen

    Aberdeen, South Dakota, 57401, United States

  • Bay Area Hospital

    Coos Bay, Oregon, 97420, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Ben Taub General Hospital

    Houston, Texas, 77030, United States

  • Benefis Healthcare- Sletten Cancer Institute

    Great Falls, Montana, 59405, United States

  • Bethesda North Hospital

    Cincinnati, Ohio, 45242, United States

  • Bhadresh Nayak MD PC-Sterling Heights

    Sterling Heights, Michigan, 48312, United States

  • Billings Clinic Cancer Center

    Billings, Montana, 59101, United States

  • Billings Clinic-Cody

    Cody, Wyoming, 82414, United States

  • Bozeman Deaconess Hospital

    Bozeman, Montana, 59715, United States

  • Broadlawns Medical Center

    Des Moines, Iowa, 50314, United States

  • Bronson Battle Creek

    Battle Creek, Michigan, 49017, United States

  • Bronson Methodist Hospital

    Kalamazoo, Michigan, 49007, United States

  • CHI Health Good Samaritan

    Kearney, Nebraska, 68847, United States

  • CHI Health Saint Francis

    Grand Island, Nebraska, 68803, United States

  • CHI Saint Vincent Cancer Center Hot Springs

    Hot Springs, Arkansas, 71913, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Cancer Center at Saint Joseph's

    Phoenix, Arizona, 85004, United States

  • Cancer Centers of Southwest Oklahoma Research

    Lawton, Oklahoma, 73505, United States

  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    Norton Shores, Michigan, 49444, United States

  • Capital Region Southwest Campus

    Jefferson City, Missouri, 65109, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401, United States

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938, United States

  • Carle at The Riverfront

    Danville, Illinois, 61832, United States

  • Caro Cancer Center

    Caro, Michigan, 48723, United States

  • Centra Lynchburg Hematology-Oncology Clinic Inc

    Lynchburg, Virginia, 24501, United States

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801, United States

  • Clackamas Radiation Oncology Center

    Clackamas, Oregon, 97015, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Coborn Cancer Center at Saint Cloud Hospital

    Saint Cloud, Minnesota, 56303, United States

  • Commonwealth Cancer Center-Corbin

    Corbin, Kentucky, 40701, United States

  • Community Hospital of Anaconda

    Anaconda, Montana, 59711, United States

  • Community Medical Hospital

    Missoula, Montana, 59804, United States

  • Creighton University Medical Center

    Omaha, Nebraska, 68131, United States

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Dayton Physician LLC-Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Dayton Physicians LLC-Atrium

    Franklin, Ohio, 45005, United States

  • Dayton Physicians LLC-Miami Valley South

    Centerville, Ohio, 45459, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Duluth Clinic Ashland

    Ashland, Wisconsin, 54806, United States

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota, 56636, United States

  • Essentia Health Cancer Center

    Duluth, Minnesota, 55805, United States

  • Essentia Health Cancer Center-South University Clinic

    Fargo, North Dakota, 58103, United States

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota, 55746, United States

  • Essentia Health Saint Joseph's Medical Center

    Brainerd, Minnesota, 56401, United States

  • Essentia Health Sandstone

    Sandstone, Minnesota, 55072, United States

  • Essentia Health Virginia Clinic

    Virginia, Minnesota, 55792, United States

  • FHCC Overlake

    Bellevue, Washington, 98004, United States

  • FHCC at Northwest Hospital

    Seattle, Washington, 98133, United States

  • Flaget Memorial Hospital

    Bardstown, Kentucky, 40004, United States

  • Franciscan Research Center-Northwest Medical Plaza

    Tacoma, Washington, 98405, United States

  • Genesee Cancer and Blood Disease Treatment Center

    Flint, Michigan, 48503, United States

  • Genesee Hematology Oncology PC

    Flint, Michigan, 48503, United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503, United States

  • George Washington University Medical Center

    Washington D.C., District of Columbia, 20037, United States

  • Glens Falls Hospital

    Glens Falls, New York, 12801, United States

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220, United States

  • Great Falls Clinic

    Great Falls, Montana, 59405, United States

  • Great Lakes Cancer Management Specialists-Doctors Park

    East China Township, Michigan, 48054, United States

  • Great Lakes Cancer Management Specialists-Macomb Medical Campus

    Macomb, Michigan, 48044, United States

  • Great Lakes Cancer Management Specialists-Macomb Professional Building

    Warren, Michigan, 48093, United States

  • Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

    Grosse Pointe Woods, Michigan, 48236, United States

  • Greater Dayton Cancer Center

    Kettering, Ohio, 45409, United States

  • Greater Regional Medical Center

    Creston, Iowa, 50801, United States

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin, 54601, United States

  • Guthrie Medical Group PC-Robert Packer Hospital

    Sayre, Pennsylvania, 18840, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Harold Alfond Center for Cancer Care

    Augusta, Maine, 04330, United States

  • Harrison Medical Center

    Bremerton, Washington, 98310, United States

  • Hawaii Cancer Care Inc - Waterfront Plaza

    Honolulu, Hawaii, 96813, United States

  • Hematology Oncology Consultants-Clarkston

    Clarkston, Michigan, 48346, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • Hickman Cancer Center

    Adrian, Michigan, 49221, United States

  • Highline Medical Center-Main Campus

    Burien, Washington, 98166, United States

  • Holy Cross Hospital

    Fort Lauderdale, Florida, 33308, United States

  • Hope Cancer Center

    Pontiac, Michigan, 48341, United States

  • Hope Cancer Clinic

    Livonia, Michigan, 48154, United States

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah, 84112, United States

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • Huron Gastroenterology PC

    Ypsilanti, Michigan, 48106, United States

  • Idaho Urologic Institute-Meridian

    Meridian, Idaho, 83642, United States

  • Illinois CancerCare - Washington

    Washington, Illinois, 61571, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Dixon

    Dixon, Illinois, 61021, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Ingalls Memorial Hospital

    Harvey, Illinois, 60426, United States

  • Iowa Lutheran Hospital

    Des Moines, Iowa, 50316, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309, United States

  • Jefferson Healthcare

    Port Townsend, Washington, 98368, United States

  • Jewish Hospital

    Louisville, Kentucky, 40202, United States

  • Jewish Hospital Medical Center South

    Shepherdsville, Kentucky, 40165, United States

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington, 99336, United States

  • Kaiser Permanente Downtown Commons

    Sacramento, California, 95814, United States

  • Kaiser Permanente Dublin

    Dublin, California, 94568, United States

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California, 95051, United States

  • Kaiser Permanente Medical Center-Vacaville

    Vacaville, California, 95688, United States

  • Kaiser Permanente Moanalua Medical Center

    Honolulu, Hawaii, 96819, United States

  • Kaiser Permanente San Leandro

    San Leandro, California, 94577, United States

  • Kaiser Permanente-Deer Valley Medical Center

    Antioch, California, 94531, United States

  • Kaiser Permanente-Fremont

    Fremont, California, 94538, United States

  • Kaiser Permanente-Fresno

    Fresno, California, 93720, United States

  • Kaiser Permanente-Modesto

    Modesto, California, 95356, United States

  • Kaiser Permanente-Oakland

    Oakland, California, 94611, United States

  • Kaiser Permanente-Richmond

    Richmond, California, 94801, United States

  • Kaiser Permanente-Roseville

    Roseville, California, 95661, United States

  • Kaiser Permanente-San Francisco

    San Francisco, California, 94115, United States

  • Kaiser Permanente-Santa Rosa

    Santa Rosa, California, 95403, United States

  • Kaiser Permanente-Santa Teresa-San Jose

    San Jose, California, 95119, United States

  • Kaiser Permanente-South Sacramento

    Sacramento, California, 95823, United States

  • Kaiser Permanente-South San Francisco

    South San Francisco, California, 94080, United States

  • Kaiser Permanente-Stockton

    Stockton, California, 95210, United States

  • Kaiser Permanente-Vallejo

    Vallejo, California, 94589, United States

  • Kaiser Permanente-Walnut Creek

    Walnut Creek, California, 94596, United States

  • Kaiser San Rafael-Gallinas

    San Rafael, California, 94903, United States

  • Kalispell Regional Medical Center

    Kalispell, Montana, 59901, United States

  • Katmai Oncology Group

    Anchorage, Alaska, 99508, United States

  • Kettering Medical Center

    Kettering, Ohio, 45429, United States

  • Kootenai Cancer Clinic

    Sandpoint, Idaho, 83864, United States

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho, 83854, United States

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho, 83814, United States

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania, 18017, United States

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania, 18103, United States

  • Lehigh Valley Hospital-Hazleton

    Hazleton, Pennsylvania, 18201, United States

  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

    Savannah, Georgia, 31405, United States

  • Littleton Adventist Hospital

    Littleton, Colorado, 80122, United States

  • Longmont United Hospital

    Longmont, Colorado, 80501, United States

  • Loyola Center for Health at Burr Ridge

    Burr Ridge, Illinois, 60527, United States

  • Loyola Medicine Homer Glen

    Homer Glen, Illinois, 60491, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • MU Health - University Hospital/Ellis Fischel Cancer Center

    Columbia, Missouri, 65212, United States

  • Macomb Hematology Oncology PC

    Warren, Michigan, 48093, United States

  • Marie Yeager Cancer Center

    Saint Joseph, Michigan, 49085, United States

  • Marjorie Weinberg Cancer Center at Loyola-Gottlieb

    Melrose Park, Illinois, 60160, United States

  • Marshfield Clinic-Minocqua Center

    Minocqua, Wisconsin, 54548, United States

  • Marshfield Medical Center - Weston

    Weston, Wisconsin, 54476, United States

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868, United States

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin, 54482, United States

  • Mary Greeley Medical Center

    Ames, Iowa, 50010, United States

  • Mayo Clinic Health System-Eau Claire Clinic

    Eau Claire, Wisconsin, 54701, United States

  • Mayo Clinic Health System-Franciscan Healthcare

    La Crosse, Wisconsin, 54601, United States

  • McFarland Clinic - Ames

    Ames, Iowa, 50010, United States

  • McFarland Clinic - Boone

    Boone, Iowa, 50036, United States

  • McFarland Clinic - Jefferson

    Jefferson, Iowa, 50129, United States

  • McFarland Clinic - Marshalltown

    Marshalltown, Iowa, 50158, United States

  • McFarland Clinic - Trinity Cancer Center

    Fort Dodge, Iowa, 50501, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medical Oncology and Hematology Associates-Des Moines

    Des Moines, Iowa, 50309, United States

  • Medical Oncology and Hematology Associates-West Des Moines

    Clive, Iowa, 50325, United States

  • Memorial Hospital of Carbondale

    Carbondale, Illinois, 62902, United States

  • Memorial Hospital of South Bend

    South Bend, Indiana, 46601, United States

  • Memorial Medical Center

    Springfield, Illinois, 62781, United States

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325, United States

  • Mercy Health - Saint Anne Hospital

    Toledo, Ohio, 43623, United States

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Mercy Medical Center

    Durango, Colorado, 81301, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa, 50266, United States

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61636, United States

  • Methodist West Hospital

    West Des Moines, Iowa, 50266-7700, United States

  • Miami Valley Hospital

    Dayton, Ohio, 45409, United States

  • Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Michael E DeBakey VA Medical Center

    Houston, Texas, 77030, United States

  • Michigan Breast Specialists-Grosse Pointe Woods

    Grosse Pointe Woods, Michigan, 48236, United States

  • Michigan Breast Specialists-Macomb Township

    Macomb, Michigan, 48044, United States

  • Michigan Breast Specialists-Warren

    Warren, Michigan, 48093, United States

  • Midlands Community Hospital

    Papillion, Nebraska, 68046, United States

  • Minneapolis VA Medical Center

    Minneapolis, Minnesota, 55417, United States

  • Mission Cancer and Blood - Laurel

    Des Moines, Iowa, 50314, United States

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, California, 93420, United States

  • Mission Hope Medical Oncology - Santa Maria

    Santa Maria, California, 93444, United States

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131, United States

  • Missouri Baptist Outpatient Center-Sunset Hills

    Sunset Hills, Missouri, 63127, United States

  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri, 63080, United States

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York, 10461, United States

  • Montefiore Medical Center-Weiler Hospital

    The Bronx, New York, 10461, United States

  • Mount Sinai Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180, United States

  • Mount Sinai Medical Center

    Miami Beach, Florida, 33140, United States

  • Munson Medical Center

    Traverse City, Michigan, 49684, United States

  • NYP/Weill Cornell Medical Center

    New York, New York, 10065, United States

  • New Hampshire Oncology Hematology PA-Concord

    Concord, New Hampshire, 03301, United States

  • Newland Medical Associates-Clarkston

    Clarkston, Michigan, 48346, United States

  • Newland Medical Associates-Pontiac

    Pontiac, Michigan, 48341, United States

  • Norris Cotton Cancer Center-North

    Saint Johnsbury, Vermont, 05819, United States

  • Northbay Cancer Center

    Vacaville, California, 95687, United States

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois, 60134, United States

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois, 60115, United States

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois, 60555, United States

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois, 60045, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Nyack Hospital

    Nyack, New York, 10960, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Oklahoma Cancer Specialists and Research Institute-Tulsa

    Tulsa, Oklahoma, 74146, United States

  • Oncology Hematology Associates of Saginaw Valley PC

    Saginaw, Michigan, 48604, United States

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada, 89102, United States

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada, 89148, United States

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, 93401, United States

  • Pacific Gynecology Specialists

    Seattle, Washington, 98104, United States

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, 96701, United States

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, 55416, United States

  • Parker Adventist Hospital

    Parker, Colorado, 80138, United States

  • Parkland Health Center - Farmington

    Farmington, Missouri, 63640, United States

  • PeaceHealth Saint John Medical Center

    Longview, Washington, 98632, United States

  • PeaceHealth Saint Joseph Medical Center

    Bellingham, Washington, 98225, United States

  • PeaceHealth Southwest Medical Center

    Vancouver, Washington, 98664, United States

  • PeaceHealth United General Medical Center

    Sedro-Woolley, Washington, 98284, United States

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, 80907, United States

  • Pocono Medical Center

    East Stroudsburg, Pennsylvania, 18301, United States

  • Porter Adventist Hospital

    Denver, Colorado, 80210, United States

  • Presbyterian Kaseman Hospital

    Albuquerque, New Mexico, 87110, United States

  • Presbyterian Rust Medical Center/Jorgensen Cancer Center

    Rio Rancho, New Mexico, 87124, United States

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina, 29640, United States

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina, 29615, United States

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina, 29650, United States

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina, 29672, United States

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina, 29316, United States

  • Prisma Health Greenville Memorial Hospital

    Greenville, South Carolina, 29605, United States

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin, 53149, United States

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin, 53066, United States

  • ProHealth Waukesha Memorial Hospital

    Waukesha, Wisconsin, 53188, United States

  • ProMedica Flower Hospital

    Sylvania, Ohio, 43560, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508, United States

  • Providence Cancer Institute Clackamas Clinic

    Clackamas, Oregon, 97015, United States

  • Providence Newberg Medical Center

    Newberg, Oregon, 97132, United States

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Providence Regional Cancer Partnership

    Everett, Washington, 98201, United States

  • Providence Regional Cancer System-Aberdeen

    Aberdeen, Washington, 98520, United States

  • Providence Regional Cancer System-Centralia

    Centralia, Washington, 98531, United States

  • Providence Regional Cancer System-Lacey

    Lacey, Washington, 98503, United States

  • Providence Regional Cancer System-Shelton

    Shelton, Washington, 98584, United States

  • Providence Regional Cancer System-Yelm

    Yelm, Washington, 98597, United States

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, California, 91505, United States

  • Providence Saint Mary Regional Cancer Center

    Walla Walla, Washington, 99362, United States

  • Providence Saint Vincent Medical Center

    Portland, Oregon, 97225, United States

  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii, 96813, United States

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii, 96817, United States

  • Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • Queens Hospital Center

    Jamaica, New York, 11432, United States

  • Reid Health

    Richmond, Indiana, 47374, United States

  • Rocky Mountain Cancer Centers-Longmont

    Longmont, Colorado, 80501, United States

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado, 80907, United States

  • Rush - Copley Medical Center

    Aurora, Illinois, 60504, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Rush-Copley Healthcare Center

    Yorkville, Illinois, 60560, United States

  • SIH Cancer Institute

    Carterville, Illinois, 62918, United States

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, 83706, United States

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, 83605, United States

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho, 83687, United States

  • Saint Alphonsus Medical Center-Baker City

    Baker City, Oregon, 97814, United States

  • Saint Alphonsus Medical Center-Ontario

    Ontario, Oregon, 97914, United States

  • Saint Anthony Hospital

    Lakewood, Colorado, 80228, United States

  • Saint Anthony Regional Hospital

    Carroll, Iowa, 51401, United States

  • Saint Charles Health System

    Bend, Oregon, 97701, United States

  • Saint Charles Health System-Redmond

    Redmond, Oregon, 97756, United States

  • Saint Clare Hospital

    Lakewood, Washington, 98499, United States

  • Saint Elizabeth Hospital

    Enumclaw, Washington, 98022, United States

  • Saint Elizabeth Regional Medical Center

    Lincoln, Nebraska, 68510, United States

  • Saint Francis Hospital

    Federal Way, Washington, 98003, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint Helena Hospital

    St. Helena, California, 94574, United States

  • Saint John Macomb-Oakland Hospital

    Warren, Michigan, 48093, United States

  • Saint Joseph Hospital East

    Lexington, Kentucky, 40509, United States

  • Saint Joseph London

    London, Kentucky, 40741, United States

  • Saint Joseph Mercy Brighton

    Brighton, Michigan, 48114, United States

  • Saint Joseph Mercy Canton

    Canton, Michigan, 48188, United States

  • Saint Joseph Mercy Chelsea

    Chelsea, Michigan, 48118, United States

  • Saint Joseph Mercy Hospital

    Ann Arbor, Michigan, 48106, United States

  • Saint Joseph Mercy Oakland

    Pontiac, Michigan, 48341, United States

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky, 40504, United States

  • Saint Joseph Regional Cancer Center

    Bryan, Texas, 77802, United States

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey, 07503, United States

  • Saint Joseph's/Candler - Bluffton Campus

    Bluffton, South Carolina, 29910, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83686, United States

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho, 83301, United States

  • Saint Luke's Hospital of Duluth

    Duluth, Minnesota, 55805, United States

  • Saint Mary Corwin Medical Center

    Pueblo, Colorado, 81004, United States

  • Saint Mary's Oncology/Hematology Associates of Marlette

    Marlette, Michigan, 48453, United States

  • Saint Mary's Oncology/Hematology Associates of West Branch

    West Branch, Michigan, 48661, United States

  • Saint Patrick Hospital - Community Hospital

    Missoula, Montana, 59802, United States

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri, 63670, United States

  • Saints Mary and Elizabeth Hospital

    Louisville, Kentucky, 40215, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Cancer Center Worthington

    Worthington, Minnesota, 56187, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601, United States

  • Sanford Medical Center Fargo

    Fargo, North Dakota, 58104, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford South University Medical Center

    Fargo, North Dakota, 58103, United States

  • Sanford Thief River Falls Medical Center

    Thief River Falls, Minnesota, 56701, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Seattle Cancer Care Alliance at EvergreenHealth

    Kirkland, Washington, 98034, United States

  • Sharp Memorial Hospital

    San Diego, California, 92123, United States

  • Shenandoah Oncology PC

    Winchester, Virginia, 22601, United States

  • Solinsky Center for Cancer Care

    Manchester, New Hampshire, 03103, United States

  • South Carolina Cancer Specialists PC

    Hilton Head Island, South Carolina, 29926-3827, United States

  • Southeast Cancer Center

    Cape Girardeau, Missouri, 63703, United States

  • Southeastern Medical Oncology Center-Clinton

    Clinton, North Carolina, 28328, United States

  • Southeastern Medical Oncology Center-Goldsboro

    Goldsboro, North Carolina, 27534, United States

  • Southeastern Medical Oncology Center-Jacksonville

    Jacksonville, North Carolina, 28546, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • Southpointe-Sanford Medical Center Fargo

    Fargo, North Dakota, 58103, United States

  • Southwest Oncology PC

    Durango, Colorado, 81301, United States

  • Sparrow Hospital

    Lansing, Michigan, 48912, United States

  • Spectrum Health Reed City Hospital

    Reed City, Michigan, 49677, United States

  • Spectrum Health at Butterworth Campus

    Grand Rapids, Michigan, 49503, United States

  • Springfield Clinic

    Springfield, Illinois, 62702, United States

  • Springfield Regional Cancer Center

    Springfield, Ohio, 45504, United States

  • Straub Clinic and Hospital

    Honolulu, Hawaii, 96813, United States

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington, 98026, United States

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington, 98029, United States

  • Swedish Medical Center-Ballard Campus

    Seattle, Washington, 98107, United States

  • Swedish Medical Center-Cherry Hill

    Seattle, Washington, 98122-5711, United States

  • Swedish Medical Center-First Hill

    Seattle, Washington, 98122, United States

  • The Carle Foundation Hospital

    Urbana, Illinois, 61801, United States

  • The New York Hospital Medical Center of Queens

    Flushing, New York, 11355, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Toledo Clinic Cancer Centers-Monroe

    Monroe, Michigan, 48162, United States

  • Toledo Clinic Cancer Centers-Toledo

    Toledo, Ohio, 43623, United States

  • TriHealth Cancer Institute-Anderson

    Cincinnati, Ohio, 45255, United States

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45247, United States

  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan, 49503, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Muskegon Hospital

    Muskegon, Michigan, 49444, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan, 48154, United States

  • Trinity Regional Medical Center

    Fort Dodge, Iowa, 50501, United States

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin, 53188, United States

  • Unity Hospital

    Fridley, Minnesota, 55432, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Michigan Health - West

    Wyoming, Michigan, 49519, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87102, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Wisconsin Carbone Cancer Center

    Madison, Wisconsin, 53792, United States

  • UofL Health Medical Center Northeast

    Louisville, Kentucky, 40245, United States

  • VCU Community Memorial Health Center

    South Hill, Virginia, 23970, United States

  • Valley Medical Center

    Renton, Washington, 98055, United States

  • Valley Radiation Oncology

    Peru, Illinois, 61354, United States

  • Veterans Affairs Connecticut Healthcare System-West Haven Campus

    West Haven, Connecticut, 06516, United States

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin, 54904, United States

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin, 53081, United States

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin, 54241, United States

  • Virginia Cancer Institute

    Richmond, Virginia, 23229, United States

  • Virginia Commonwealth University/Massey Cancer Center

    Richmond, Virginia, 23298, United States

  • Wake Forest Baptist Health - Wilkes Medical Center

    Wilkesboro, North Carolina, 28659, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Wake Forest University at Clemmons

    Clemmons, North Carolina, 27012, United States

  • Walter Knox Memorial Hospital

    Emmett, Idaho, 83617, United States

  • Welch Cancer Center

    Sheridan, Wyoming, 82801, United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan, 49007, United States

  • West Suburban Medical Center

    River Forest, Illinois, 60305, United States

  • West Virginia University Charleston Division

    Charleston, West Virginia, 25304, United States

  • Western Illinois Cancer Treatment Center

    Galesburg, Illinois, 61401, United States

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