TYPE 1 DIABETES MELLITUS

This study tests an experimental drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing its own insulin, reducing the need for injected insulin. About 66 participants will receiv…

This study follows about 30 people with type 1 diabetes who have already received islet cell transplants. The goal is to see how long the transplanted cells keep working to produce insulin. Participants must take lifelong immunosuppressive drugs to prevent rejection.

This study tests a new way to manage type 1 diabetes in teens aged 10 to 17 who were just diagnosed. Instead of multiple daily injections, participants use inhaled insulin (Afrezza) along with a long-acting insulin shot. The goal is to see if this combination helps keep blood sug…

This study is testing whether taking a specific probiotic (Desulfovibrio piger) for 4 weeks can lower inflammation and help preserve the body's remaining insulin-producing cells in adults who have had type 1 diabetes for over 5 years. The trial involves 20 participants and compar…

This study tests a new medicine called CNP-103 in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either CNP-103 or a placebo over 90 …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells (the cells that make insulin) placed inside tiny capsules. The goal is to see if transplanting these cells is safe and can help adults with unstable type 1 diabetes who still have dangerous lo…

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if teplizumab can help control blood sugar and reduce the need for insulin at mealtimes. Participants will receive either teplizumab or a placebo …

This early-stage study tests a new drug called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to check safety, how the drug moves through the body, and how well it controls blood sugar compared to a standard insulin. The study has four parts a…

This study tests a drug called MTX228 to see if it can help regrow insulin-producing beta cells in adults with type 1 diabetes. About 24 participants will receive different doses to find the best one. The goal is to reduce the need for insulin injections and improve blood sugar c…

This study tests a new drug called tegoprubart in people with type 1 diabetes who have dangerous low blood sugar episodes and are getting islet cell transplants. The drug aims to prevent the immune system from attacking the transplanted cells without using standard anti-rejection…

This study tests whether a new online survey, called Spotlight AQ, helps teens and young adults (ages 16-25) with type 1 diabetes better manage their blood sugar levels. Participants will use the survey before two clinic visits and share their feedback. The goal is to see if the …

This study tests a drug called frexalimab in 192 people recently diagnosed with type 1 diabetes who are already using insulin. The goal is to see if it can help the pancreas keep making some insulin naturally, reducing the amount of insulin needed. Participants will receive eithe…

This study tests whether the drug Myfortic can prevent the immune system from becoming overly sensitive after an islet transplant has failed in people with type 1 diabetes. The trial involves 18 adults who have lost their islet graft. Participants will take Myfortic alone for two…

This early-stage study tests a new treatment called GNTI-122, made from a person's own blood cells, in 16 adults recently diagnosed with type 1 diabetes. The goal is to see if it is safe and how it affects the body's ability to produce insulin. Participants receive one dose and a…

This study checks if a new insulin pump (NMX8) is safe when used with a continuous glucose monitor in people with type 1 or type 2 diabetes. About 400 participants aged 7 to 85 will use their usual therapy with the sensor for up to 40 days, then use the new pump for 90 days. The …

This study looks at whether a 15-minute brisk walk can help young adults with type 1 diabetes control their blood sugar when they forget to take insulin before a meal. Participants will take insulin after eating and then walk to see if it prevents high blood sugar. The goal is to…

This study tests whether a continuous glucose monitor (CGM) called Accu-Chek SmartGuide helps adults with type 1 or type 2 diabetes spend more time with blood sugar in the target range (70-180 mg/dL) compared to standard fingerstick testing. About 270 adults who use daily insulin…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can help preserve the pancreas cells that make insulin in adults with type 1 diabetes. About 96 people aged 18 to 65 will take either the drug plus insulin or insulin alone for 24 weeks, then …

This study tests a drug called teplizumab in Japanese people aged 8 to 34 who have Stage 2 type 1 diabetes, meaning their blood sugar is starting to rise but they don't need insulin yet. The goal is to see if a 14-day IV treatment can delay or prevent the disease from progressing…

This study looks at whether fluoxetine (Prozac) and/or DHEA (a natural hormone) can help people with type 1 diabetes better defend against low blood sugar (hypoglycemia). About 60 adults with type 1 diabetes will receive either one or both of these substances or a placebo, and th…

This study checks how accurate a new glucose sensor called LabPatch is at measuring blood sugar in people with diabetes who use insulin. About 60 adults with type 1 or type 2 diabetes will wear the sensor during a 6-hour visit. Their readings will be compared to standard lab test…

This study is testing how well a new continuous glucose monitor, CareSens Air 3, measures blood sugar levels in adults with type 1 diabetes. About 32 participants will wear the device and have their blood sugar compared to a standard lab test. The goal is to see if the monitor is…

This study tests whether teaching children with type 1 diabetes through fun games (gamification) can improve their health knowledge and quality of life. About 52 kids aged 8-12 will be split into two groups: one gets standard education, the other gets game-based lessons added. Re…

This study tests whether a 4-week online self-compassion training program is helpful and acceptable for adults with type 1 or type 2 diabetes who are struggling with diabetes-related distress. About 50 participants will be randomly assigned to the program or a control group. The …

This study aims to see if there are different subgroups among people with type 1 diabetes by using artificial intelligence to analyze their health data. Researchers will look at clinical records and glucose monitoring information from 800 adults. Participants only need to allow a…

This study looks at how caring for a child recently diagnosed with type 1 diabetes affects parents' work, daily life, and well-being. About 100 Canadian caregivers will fill out surveys about their productivity, healthcare use, and quality of life. The goal is to better understan…

This study looks at whether entering 'fake carbs' into an insulin pump improves blood sugar control in children and teens with type 1 diabetes. Forty participants aged 7-18 will try two weeks with fake carbs and two weeks without. The goal is to see if this common practice actual…

This study follows people who previously took part in type 1 diabetes treatment trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could help…

This study follows people with type 1 diabetes whose islet transplants have stopped working. Researchers want to learn how the body's immune system changes after the graft is lost. Participants must have had at least one islet transplant without any other organ transplant. No new…

This observational study looks at whether a combination of treatments can reduce how much oxygen the heart and kidneys need in people with type 1 diabetes. About 40 adults with long-standing diabetes will be followed for two years. Researchers will use special scans and lab tests…

This study is monitoring the safety and performance of the Twiist insulin delivery system in 1,875 adults and children (ages 6 and up) with type 1 diabetes. Participants are already using the Twiist system, and researchers will track severe low blood sugar events, diabetic ketoac…

This study will enroll 150 adults with type 1 diabetes to see if a structured education program, combined with regular clinic visits, improves blood sugar control and self-management. Participants will attend classes covering diet, exercise, insulin use, and more, then be followe…

This study measures oxidative stress (a type of cell damage) in 150 adults with either type 1 diabetes or LADA. Researchers will take blood samples once and, for newly diagnosed patients, again after 3 months of treatment. The goal is to see if stress markers differ between the t…

This study looks at why diabetes devices like insulin pumps and continuous glucose monitors can cause skin irritation, eczema, or fatty lumps in children with type 1 diabetes. Researchers will use non-invasive tools to measure skin health and blood flow. The goal is to find bette…

This study tests two experimental insulin formulas to see if they work faster than a standard insulin in adults with type 1 diabetes. Twenty participants will receive each insulin type during separate visits, and blood samples will be taken to measure how quickly the insulin is a…

This study explores the many factors that influence physical activity in adolescents with type 1 diabetes, from personal motivation to school and community support. About 55 teens aged 9-18 will wear activity trackers and fill out questionnaires. The goal is to identify barriers …

This study is creating a system to identify people at high risk for type 1 diabetes (T1D) before symptoms appear. Researchers will follow 340 participants—including T1D patients, their close relatives, and healthy volunteers—for up to 4 years. They will collect blood, urine, and …

This early-phase study looks at whether reducing high insulin levels with an SGLT2 inhibitor can improve heart and blood sugar health in people with type 1 diabetes. Researchers will compare results with people who have a mild genetic form of diabetes (GCK-MODY) and healthy volun…

This study looks at whether diabetic ketoacidosis (DKA) causes early injury to the kidneys and heart in children newly diagnosed with type 1 diabetes. Researchers will measure specific markers in the blood and urine of 45 children with and without DKA, plus healthy controls. The …