TYPE 1 DIABETES MELLITUS

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerous lows and highs. Participants will use the device during hotel and o…

This study tests a flexible digital insulin dose calculator in children under 12 with type 1 diabetes who use multiple daily injections. The tool helps calculate the right insulin dose based on meals and blood sugar levels. The goal is to see if it improves blood sugar control an…

This study compares two treatments to see if a low-dose drug called ATG can delay or prevent type 1 diabetes as well as the approved drug teplizumab. About 60 people aged 4 to 35 who are at high risk (stage 2) will receive either two infusions of ATG or 14 infusions of teplizumab…

This study tests a web-based education program for teens with type 1 diabetes and their mothers. The goal is to improve eating habits, blood sugar control, and self-management. About 72 teens and their mothers will take part, with some receiving the web program and others standar…

This study tests whether tirzepatide, a drug already used for type 2 diabetes, can improve how the body uses insulin and controls blood sugar in people with type 1 diabetes. About 44 adults with type 1 diabetes and a BMI of 27 or higher will receive either tirzepatide or a placeb…

This study tests whether tirzepatide, a weekly medication for type 2 diabetes, can help adults with type 1 diabetes use an automated insulin pump without counting carbohydrates at meals. About 105 participants in Canada and Switzerland will either add tirzepatide to their pump th…

This study tests a newer insulin pump system (Omnipod 6) against an older one (Omnipod 5) in 200 people aged 14-75 with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use each system for a period to see which helps them spend more time in a healthy…

This study tests whether a lower ketone alarm (1.0 mmol/L) is better than a higher one (1.5 mmol/L) at preventing diabetic ketoacidosis (DKA) in people with type 1 diabetes who take the drug dapagliflozin. About 115 adults will use a continuous ketone monitor and receive educatio…

This study tests whether a low-dose glucagon injection before moderate exercise can prevent blood sugar drops in 18 adults with type 1 diabetes who use an automated insulin pump. Participants will exercise after a meal, and researchers will compare blood sugar changes when using …

This study will test whether artificial intelligence (AI) can effectively screen for diabetic retinopathy (eye damage) in 400 children with type 1 diabetes. Participants will have their eyes photographed and the AI's results will be compared to standard exams. The goal is to see …

This study will test if giving parents of children with type 1 diabetes special education and motivational interviews can improve their child's diabetes self-management and quality of life. About 42 parents of children aged 8-12 will take part. The goal is to see if supporting pa…

This study tests if a natural bee product called propolis, delivered into the skin using ultrasound, can help heal diabetic foot ulcers faster. Diabetic foot ulcers are slow-healing wounds that can lead to serious infections. The study will compare the propolis-ultrasound treatme…

This study looks at whether resistance training (like lifting weights) can reduce depression and improve sleep and quality of life in women with type 1 diabetes. Researchers will enroll 78 women who have had diabetes for over 5 years and have mild to moderate depression. Particip…

This study looks at whether fear of hypoglycemia (low blood sugar) affects the heart, physical activity, and exercise ability in children and teens with type 1 diabetes. About 67 participants aged 10-18 will answer surveys and have their heart rate, blood pressure, and oxygen lev…

This study looks at why women with type 1 diabetes are more likely to develop polycystic ovary syndrome (PCOS) and high levels of male hormones. Researchers will compare 60 participants across five groups, including women with and without diabetes and PCOS, as well as men with di…

This study looks at how different temperatures (cold, normal, and hot) affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in three different temperature rooms while researchers monitor their blood sugar, heart rate, and b…

This study will look back at medical records of 500 Chinese adults with type 1 diabetes to see if adding glucose-lowering pills to their insulin helps control blood sugar better than insulin alone. The goal is to understand real-world effects and safety over time. No new treatmen…

This study involves 100 university students with type 1 diabetes. Researchers will test their knowledge of carbohydrate counting and then provide a structured education session. After three months, they will check if blood sugar control (HbA1c) and carb counting skills have impro…

This study looks at how the amount of fat in a meal and the menstrual cycle affect blood sugar levels in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat low-fat and high-fat meals, and women will be tested at different points in their cycle. The goal is to l…

This study looks at whether the arthritis drug sulfasalazine makes the standard diabetes blood test (HbA1c) unreliable. The drug can shorten red blood cell life, which may lower HbA1c levels and hide true blood sugar problems. Researchers will use continuous glucose monitors to g…

This study looks at how to safely use a diabetes medication (SGLT2 inhibitor) in people with type 1 diabetes and mild-to-moderate chronic kidney disease. Researchers will track blood sugar and ketone levels using continuous monitors to identify risk factors for diabetic ketoacido…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young adults with type 1 diabetes. Twenty people aged 15-24 will drink a sports drink and have their blood vessel function measured. The goal is to understand if the…