Type 1 diabetes mellitus

Researchers are testing two experimental gene therapies, VV-14299 and VV-14300, in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin pump. The therapies are injected into muscle and are designed to work togeth…

Researchers are testing a gene therapy called VV-14300 in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin delivery system. The therapy uses a harmless virus to deliver the glucokinase gene into muscle, where…

This trial tests whether the GX-01S continuous glucose monitoring system helps adults with type 1 or type 2 diabetes improve their blood sugar control. Participants wear the sensor for about 4.5 months, with the first 15 days blinded to establish a baseline, then full access to r…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This study tests whether a mobile app that provides structured diabetes education can help adolescents with type 1 diabetes improve their blood sugar control, confidence, and self-care habits. Participants aged 10 to 19 with type 1 diabetes and an HbA1c of 7% or higher will use t…

This study tests whether the shingles vaccine Shingrix and the diabetes drug semaglutide, alone or together, can help preserve the body's ability to make insulin in adults recently diagnosed with type 1 diabetes. The goal is to slow the immune attack on insulin-producing cells an…

This early-phase trial tests a three-step immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months). The goal is to preserve the body's remaining insulin production by calming the immune attack and teaching the immune system to tolerate insulin. Sixty …

This study tests a web-based education program for teens with type 1 diabetes and their mothers. The goal is to see if the program helps improve eating habits, blood sugar control, and self-management. About 72 teens and their moms will take part, with some teens getting the prog…

This study tests whether using a continuous ketone monitor with a lower alarm threshold (1.0 vs 1.5 mmol/L) can reduce the risk of diabetic ketoacidosis in people with type 1 diabetes who take dapagliflozin, a drug typically used for type 2 diabetes. 115 adults will wear a dual g…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

Researchers are testing DiaFootCare, a mobile app that teaches foot self-care, sends medication and care reminders, guides users through taking wound photos, and shares information with pharmacists. The trial enrolls 139 adults aged 40 to 60 with diabetes and an active foot ulcer…

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This study tests whether an AI-powered educational platform can help parents of children with type 1 diabetes count carbohydrates more accurately and manage diabetes better. About 80 parents will either use the AI platform plus usual care or usual care alone for 12 weeks. The goa…

This study will test whether resistance training and breathing exercises can reduce depression and improve sleep and quality of life in women with type 1 diabetes. About 78 women with good blood sugar control and mild to moderate depression will take part. The exercises target ma…

This study tests whether teaching parents of children with type 1 diabetes can improve the child's diabetes management and quality of life. About 42 families with children aged 8-12 will take part. Parents will receive special education sessions and motivational interviews. The g…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study looks at how children and teens with type 1 diabetes use the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin based on glucose readings. Researchers will track how quickly families adopt the system, who chooses it, and how it affects blood sugar co…

This pilot study tests a new continuous glucose monitor (CGM) called SAVA in 20 adults with Type 1 Diabetes. Participants wear three SAVA sensors and one standard sensor for 15 days to check how well the SAVA measures blood sugar compared to lab tests. The study also looks at com…

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This study looks at whether fear of hypoglycemia (low blood sugar) affects the heart, physical activity, and exercise ability in children and teens with type 1 diabetes. About 67 participants aged 10-18 will answer questionnaires and have their heart rate, blood pressure, and oxy…

This study looks at how different temperatures—cold, normal, and hot—affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in a special room at each temperature for two hours while researchers monitor their blood sugar, hear…

This study looks at how the amount of fat in a meal and a woman's menstrual cycle affect blood sugar after eating in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat standardized low-fat and high-fat meals while wearing continuous glucose monitors. The goal i…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young people aged 15-24 with type 1 diabetes. Researchers will measure blood vessel function before and after drinking a sweetened sports drink. The goal is to under…

This study will look back at medical records of 500 Chinese adults with type 1 diabetes to see if adding glucose-lowering pills to insulin helps control blood sugar better than insulin alone. The main goal is to check changes in HbA1c (average blood sugar over 2-3 months) and how…

This study looks at how well university students with type 1 diabetes can estimate carbohydrates in their meals and whether that affects their blood sugar control. Researchers will give a one-time educational session on carb counting and insulin adjustment, then check blood sugar…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study looks at menstrual cycle changes in adolescent girls with diabetes compared to those without. Researchers will track cycle length, frequency, and regularity, and check links to blood sugar control and body weight. The goal is to identify risk factors and improve care f…