TYPE 1 DIABETES MELLITUS

This study tests whether a daily pill called fenofibrate can slow or prevent worsening of diabetic eye disease (retinopathy) in adults with type 1 diabetes. About 412 participants with early eye changes are taking either the drug or a placebo for several years. The goal is to see…

This phase 3 trial tests whether transplanting insulin-making cells (islets) from donors can help people with type 1 diabetes achieve near-normal blood sugar without dangerous lows. 21 adults with severe hypoglycemia episodes received the transplant plus lifelong immune-suppressi…

This study tests whether giving two immune-modulating drugs (rituximab followed by abatacept) can better preserve the body's ability to produce insulin in people newly diagnosed with type 1 diabetes, compared to rituximab alone. About 74 participants aged 8 to 45 will be followed…

This early-phase trial tests a new vaccine made from a person's own immune cells. The goal is to teach the immune system to stop attacking the pancreas, so the body can keep making some insulin. Six adults with type 1 diabetes who use insulin and have no other diabetes complicati…

This study tests whether taking a probiotic supplement can lower inflammation in children and teens recently diagnosed with type 1 diabetes. The goal is to see if changing gut bacteria can slow the disease's progression. About 43 participants aged 5-17 will receive either the pro…

This study tests an experimental treatment called Diamyd (retogatein) in 321 adolescents and adults recently diagnosed with type 1 diabetes who have a specific genetic marker (HLA DR3-DQ2). The goal is to see if three injections into a lymph node, along with vitamin D, can help p…

This study tests whether transplanting insulin-producing cells from donors can help people with type 1 diabetes control blood sugar better and possibly stop taking insulin. Participants receive anti-rejection drugs to protect the transplanted cells and are followed for five years…

This study tests whether a probiotic called Lactiplantibacillus plantarum 299v can reduce inflammation and help preserve the body's ability to produce insulin in people recently diagnosed with type 1 diabetes. About 60 participants aged 3 to 45 will receive either the probiotic o…

This study tests whether a smartphone app called Diabetes M helps people with type 1 diabetes calculate their insulin doses more accurately than their usual method. Thirty adults will use the app for two weeks and compare their blood sugar control to two weeks without it. The goa…

This study tests whether a hybrid closed-loop insulin pump system (mylife CamAPS FX) can improve blood sugar control and quality of life in 30 adults with type 1 diabetes who have chronically high blood sugar (HbA1c ≥ 9%) and psychological challenges. Participants are randomly as…

This study tests a new drug called brivekimig in people recently diagnosed with type 1 diabetes. The goal is to see if it can help preserve the body's ability to make some insulin, reducing the need for injected insulin. About 84 adults and adolescents will receive either the dru…

This study tests a device called the Cell Pouch, which is implanted in the abdomen to house insulin-producing cells for people with Type 1 Diabetes who have dangerous low blood sugar episodes. The goal is to see if the device is safe and can help the cells survive long-term, pote…

This study looks at whether Swedish massage or yoga can help lower blood sugar levels in children aged 6 to 12 with type 1 diabetes. Both techniques are relaxing and may reduce stress, which can help control blood sugar. The study involves 50 children from Cairo who do not have o…

This study tests a smartphone app called PACTAID in 20 adults with type 1 diabetes who use automated insulin pumps. The app helps manage blood sugar levels during and after exercise. Researchers want to see if the app improves glucose control and heart health.

This study looks at whether improving metabolic health through a 3-month lifestyle or blood sugar program can change epigenetic marks in the sperm of overweight men with type 1 or type 2 diabetes. Researchers will measure sperm concentration and DNA methylation patterns before an…

This study follows over 1,400 people with type 1 diabetes who were part of an earlier trial. Researchers are tracking how early intensive blood sugar control affects long-term health, including eye, kidney, nerve, and heart problems. The goal is to understand risk factors for com…