TREATMENT RESISTANT DEPRESSION (TRD)

This early-phase trial tests a personalized approach to deep brain stimulation (DBS) for people with treatment-resistant depression. Researchers use brain scans and recordings to find the best spot and settings for each patient's implant. The goal is to see if this tailored DBS c…

This study tests whether a personalized, step-by-step treatment plan (algorithm-guided treatment) works better than standard care for people with treatment-resistant depression. About 80 adults aged 18-65 who have not felt well for at least a year will be randomly assigned to one…

This study looks at whether adding a structured exercise program to a type of brain stimulation called iTBS can help people with depression that hasn't responded to medication. The researchers will compare the combination of exercise and iTBS to iTBS alone in 20 physically inacti…

This study looks at whether a single dose of intravenous ketamine can rapidly improve symptoms in adults with treatment-resistant depression. Researchers will measure changes in brain chemicals (GABA and glutamate) and depression scores. 30 participants will receive either ketami…

This study looks at whether adding coaching sessions can improve the effects of ketamine or esketamine treatment for people with treatment-resistant depression. About 20 adults who already get ketamine at Massachusetts General Hospital will try 12 coaching sessions. The goal is t…

This study tests whether a new drug called ALTO-207 can reduce depression symptoms in adults whose depression has not responded to at least 2 other treatments. About 178 people will receive either ALTO-207 or a placebo for several weeks. The main goal is to see if the drug improv…

This study tests whether a safe, at-home brain stimulation method called tDCS can help people with depression that hasn't improved with standard treatments. Ten adults with major depression will use a headset at home for 20-minute sessions, five times a week for two weeks, while …

This study tests whether adding therapy sessions before and after esketamine (Spravato®) nasal spray can improve mood and daily function in adults with treatment-resistant depression. Twenty participants will be randomly assigned to receive esketamine with or without these suppor…

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) on the forehead to help people with treatment-resistant depression. Researchers will compare two different light frequencies (10 Hz and 40 Hz) to see which works better for easing symptoms…

This study tests two forms of transcranial magnetic stimulation (TMS) in 60 adults whose depression hasn't improved with standard treatments. One method uses short bursts of magnetic pulses (iTBS), the other uses continuous pulses (cTBS). Both are given daily for two weeks, then …

This study tests if using magnetic brain stimulation right before electroconvulsive therapy (ECT) can make ECT work better for people with hard-to-treat depression. About 50 adults with severe depression will receive both treatments, and researchers will measure changes in seizur…

This study watches 100 adults with treatment-resistant depression who are taking esketamine nasal spray as part of their normal care. Researchers want to see how well it works, who responds best, and how it affects daily life, work, and mood. They will also look at genetic and br…