Ketamine's brain secrets: new study targets Depression's root
NCT ID NCT06668571
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 37 times
Summary
This study looks at how a single dose of ketamine affects key brain chemicals (GABA and glutamate) in 30 adults with treatment-resistant depression. Half receive ketamine, half a placebo, while brain scans and blood tests track chemical changes. The goal is to understand why ketamine can rapidly lift depression, which could lead to better treatments.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine
What this could lead to
If successful, this study could reveal how ketamine rapidly eases depression, pointing toward better treatments for those who haven't improved with standard antidepressants.
What could go wrong
This is a small, early-phase study focused on understanding brain chemistry, not proving a new treatment works. Results may not apply to everyone with depression.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.