DEPRESSIVE DISORDER, TREATMENT-RESISTANT

This study is testing whether an experimental medication called ACP-211 can help adults with major depressive disorder who haven't gotten better with standard antidepressant treatments. Researchers will compare ACP-211 against a placebo (inactive pill) to see if it reduces depres…

This study tests whether esketamine nasal spray can reduce depression symptoms in Korean adults whose depression has not improved with other treatments. About 47 participants will use the spray for 4 weeks, and researchers will measure changes using a standard depression rating s…

This study tests whether giving multiple brain stimulation sessions per day (accelerated) works better than one session per day (conventional) for treating depression in people aged 60 and older. All 280 participants will receive active treatment, but some get the faster schedule…

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This study looks at whether a single dose of intravenous ketamine can rapidly improve symptoms in adults with treatment-resistant depression. Researchers will measure changes in brain chemicals (GABA and glutamate) and depression scores. 30 participants will receive either ketami…

This study compares two types of transcranial magnetic stimulation (rTMS and deep TMS) to see which is better at treating depression that hasn't improved with standard treatments. About 152 adults with resistant depression will receive 20 sessions over 4 weeks, plus follow-ups fo…

This study tests whether adding a text-message support program (Text4Support) to standard brain stimulation therapy (rTMS) helps people with treatment-resistant depression more than rTMS alone. About 200 adults who have not gotten better with at least two antidepressants will tak…