TREATMENT RESISTANT DEPRESSION (TRD)
Clinical trials for TREATMENT RESISTANT DEPRESSION (TRD) explained in plain language.
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Could a keto diet supercharge brain therapy for depression?
Symptom relief Not yet recruitingThis study tests whether adding a ketogenic (keto) diet to a personalized brain stimulation treatment can better reduce depression symptoms in adults whose depression hasn't improved with standard treatments. Sixty participants will follow either a keto diet or a standard healthy…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: NA • Sponsor: Sunnybrook Health Sciences Centre • Aim: Symptom relief
Last updated May 26, 2026 05:44 UTC
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New Brain-Mapping technique could boost depression treatment
Symptom relief Not yet recruitingThis study tests a new way to deliver repetitive transcranial magnetic stimulation (rTMS) for people with treatment-resistant depression. Instead of the standard approach, doctors will use a brain-mapping method to target a specific area more precisely. The goal is to see if this…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: Soterix Medical • Aim: Symptom relief
Last updated May 26, 2026 04:37 UTC
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New brain zapping technique aims to lift severe depression faster
Symptom relief Not yet recruitingThis study tests a quick, non-invasive brain stimulation method called accelerated intermittent theta-burst stimulation (aiTBS) for people with depression that hasn't improved with standard treatments. About 247 adults aged 18-65 will be randomly assigned to receive either aiTBS …
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated May 22, 2026 14:03 UTC
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Ketamine therapy holds promise for Treatment-Resistant depression
Symptom relief Not yet recruitingThis study tests whether ketamine, combined with talk therapy, can help people with depression that hasn't improved with other treatments. About 25 adults will receive 1-2 doses of ketamine along with 3-4 psychotherapy sessions. Researchers will use brain scans to see how ketamin…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: University of Rochester • Aim: Symptom relief
Last updated May 22, 2026 14:02 UTC
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Can a depression drug remove the psychedelic trip but keep the mood boost?
Symptom relief Not yet recruitingThis study tests whether combining psilocybin (the active ingredient in magic mushrooms) with the antidepressant trazodone can improve depression symptoms without causing intense psychedelic experiences. About 112 adults with treatment-resistant depression will receive either psi…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: Centre Hospitalier St Anne • Aim: Symptom relief
Last updated May 20, 2026 11:57 UTC
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Brain wave study aims to decode Ketamine's impact on tough depression
Knowledge-focused Not yet recruitingThis study will test whether brain wave (EEG) patterns can serve as a marker for how ketamine affects depression symptoms. Twenty adults with treatment-resistant depression will receive ketamine infusions while researchers monitor their brain activity and mood changes. The goal i…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE1 • Sponsor: Soterix Medical • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC