Treatment resistant depression (TRD)

This trial tests whether maintenance rTMS—a non-invasive brain stimulation technique—can prevent depression from returning better than the medication quetiapine in people with treatment-resistant depression. After an initial course of rTMS, participants are randomly assigned to r…

This study tests whether brain imaging and clinical data can help select the best treatment for people with depression that hasn't improved with standard therapies. Participants receive either repetitive transcranial magnetic stimulation (rTMS) or ketamine, and researchers check …

This study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…

Researchers compare two ways of presenting intravenous ketamine to people with treatment-resistant depression: a psychedelic framing with music, eye masks, and inner-experience support, versus a biomedical framing with standard clinical support. The trial measures changes in depr…

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This study tests whether ketamine injections combined with psychotherapy can help people with treatment-resistant depression. Researchers will use brain scans to see if changes in brain activity link to improvements. About 25 adults will receive 1-2 doses of ketamine and several …

This study tests two types of brain stimulation for people with depression that hasn't improved with medication. About 247 adults will receive either a precise, guided form of stimulation, a standard form, or a fake (sham) procedure. The goal is to see if these treatments can saf…

This study tests a new method of delivering repetitive transcranial magnetic stimulation (rTMS) for people with treatment-resistant depression. Instead of the standard approach, the new method uses brain surface mapping to target a specific area. The trial will compare the two me…

This study aims to develop a brain wave (EEG) test that can measure how ketamine affects depression symptoms. Researchers will give ketamine infusions to 20 adults with treatment-resistant depression and track changes in their mood and brain signals. The goal is to find a reliabl…