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New study tests faster brain zaps for stubborn depression

NCT ID NCT07264452

Symptom relief Sponsor: Ataturk University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two accelerated forms of transcranial magnetic stimulation (TMS) for people with treatment-resistant depression. 60 participants will receive either intermittent or continuous theta burst stimulation over two weeks, with a 12-week follow-up. The goal is to see which type better reduces depression, anxiety, and suicidal thoughts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS) using a figure-eight coil
What this could lead to
If successful, this could identify a more effective TMS protocol for people with depression that hasn't responded to medication.
What could go wrong
This is a small, early-stage study with only 60 participants. The results may not apply to everyone, and the benefits might not last beyond the 12-week follow-up.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 18 to 65 years old 2. Patients diagnosed with Major Depressive Disorder according to DSM 5 and the severity of their illness 3. Scoring 7 points or more on the Maudsley staging method 4. Having depression unresponsive to 2 different antidepressants 5. No clinical mental retardation 6. Agree to participate in the study 7. Hamilton Depression Rating Scale-17 \[HDRS\] score of 20 or higher 8. Montgomery Asberg Depression Rating Scale \[MADRS\] score of 20 or above 9. Being right hand dominant 10. Having used the same antidepressant at the same dose for the last 4 weeks Exclusion Criteria: 1. Diagnosed with a neurological or metabolic disease that affects cognitive functions (Systemic diseases such as diabetes mellitus, cardiovascular disease, cerebrovascular disease, chronic renal failure, Parkinson's disease, multiple sclerosis, polyneuropathy, inflammatory rheumatologic disease and malignancies) 2. Having a foreign body such as a pacemaker, intracranial implant that can magnetically interact 3. Hearing and visual impairments that prevent communication 4. Unstable or acute medical conditions 5. Pregnancy or breastfeeding 6. Having a primary psychiatric disorder other than major depressive disorder 7. Being diagnosed with severe MDD with psychotic features

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Accelerated protocol Continuous theta burst stimulation Intermittent theta burst stimulation Transcranial magnetic stimulation Treatment resistant depression (TRD) Unilateral RTMS

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ataturk University

    RECRUITING

    Erzurum, 25240, Turkey (Türkiye)

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