TREATMENT

This study tests a personalized vaccine (Neo-DC) made from a patient's own immune cells to target unique markers on their advanced solid tumor. The vaccine aims to teach the immune system to attack the cancer. The trial enrolls 9 adults with advanced solid tumors who have not res…

This study is testing a three-drug combination (venetoclax, ivosidenib, and azacitidine) in adults with a specific genetic form of acute myeloid leukemia (AML) called IDH1-mutated. The goal is to see if this combination can improve remission rates and survival. About 23 participa…

This study tests a new treatment for children, teens, and young adults (ages 2 to 34) with newly diagnosed classical Hodgkin lymphoma. The drug brentuximab vedotin replaces two older drugs in the standard chemo mix, with the goal of achieving a faster complete response on PET sca…

This study compares a new drug called daratumumab with the standard drug rituximab in 160 adults with immune thrombocytopenia (ITP) whose condition did not improve or came back after steroid treatment. The goal is to see which drug works better at raising platelet counts and redu…

This study enrolls 544 smokers who want to quit but have had trouble with standard medications. Participants receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks, with treatment adjusted based on individual response. All visits are remote, and the st…

This study tests whether a combination of Chinese herbs and tiny acupuncture needles can help girls with idiopathic precocious puberty (early puberty). The goal is to shrink or stop breast growth and keep bone age from advancing too fast. About 170 girls will be treated for six m…

This early-phase study tests whether stem cells from amniotic fluid can help heal painful skin wounds (calciphylaxis) in people with chronic kidney disease. Nine participants will receive the stem cell treatment, and researchers will measure wound healing and pain levels. The goa…

This study tests whether combining two drugs (rituximab and daratumumab) can safely raise platelet counts in adults with immune thrombocytopenia (ITP) who did not get better with steroids. About 20 participants will receive the combo and be monitored for 12 weeks. The goal is to …

This study tests a special laser (micropulse) to treat diabetic macular edema, a swelling in the back of the eye that can blur vision. Researchers will compare how well it works in people getting treatment for the first time versus those who haven't improved with other treatments…

This study tests whether a newer acid-blocking drug (P-CAB) works better than a standard one (PPI) when used as part of a 4-drug therapy for H. pylori infection. About 320 adults who have not been treated before will take one of the two combinations. The goal is to see which trea…

This study tests two types of special glasses lenses designed to slow the progression of nearsightedness (myopia) in children aged 6 to 14. About 120 children will wear the lenses daily for one year and have regular eye exams. The goal is to see if the lenses reduce how much the …

This study compares two medications, daratumumab and rituximab, in children aged 6 to 17 with immune thrombocytopenia (ITP) whose condition did not improve or came back after steroid treatment. ITP causes low platelet counts, leading to bruising and bleeding. The goal is to see w…

This study tests whether adding an anti-CD38 antibody to the standard drug rituximab works better than rituximab alone for adults with immune thrombocytopenia (ITP) who did not improve or relapsed after steroid treatment. The goal is to safely raise platelet counts and reduce ble…

This study tests a new drug (anti-CD38 antibody) in 60 children aged 6 and older with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The drug aims to raise platelet counts safely in kids who haven't improved with standard …

This study tests whether a higher dose of aerobic exercise, started within two weeks of a concussion, helps teens recover faster. Researchers will measure symptom resolution, brain inflammation markers, and anxiety or depression changes. The goal is to create better rehabilitatio…

This study compares two surgical techniques for removing a uterine septum, a wall of tissue inside the uterus that can cause problems. Researchers want to see if using scissors without electricity is better than using an electric tool. The study will measure surgery time, costs, …

This study is for people with medication-overuse headache, a condition where taking too much pain medicine makes headaches worse. Researchers want to find out which patient factors (like age or headache history) affect how well a nerve block injection works. 70 adults will get an…