SUBSTANCE USE DISORDER (SUD)

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This early study tests whether a personalized deep brain stimulation (DBS) device can safely reduce cravings and opioid use in people with severe, treatment-resistant opioid use disorder. Six adults will undergo brain mapping to identify targets linked to craving, then receive ad…

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This study tests a digital group program called WORTH Paths for women aged 18-44 who have been involved in the criminal legal system, have a substance use disorder, and need contraception but aren't using it. The program includes three virtual group sessions with interactive acti…

This study tests two digital treatment programs for people recently released from prison who have a history of substance use problems. The goal is to see if these programs are practical and helpful in preventing relapse and return to prison. About 20 participants will use the dig…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests a program called Mobile Enhanced Prevention Support (MEPS) for people recently released from jail or prison. The program pairs participants with a peer mentor, offers up to $600 in cash incentives for using medical and non-medical services, and provides a smartph…

This study is testing whether a long-acting injectable HIV prevention drug, cabotegravir, works well for people who inject drugs. One hundred adults who have injected non-prescription drugs in the past 6 months and are at risk for HIV through sex will receive the shot along with …

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This study looks at whether peer support workers—people who have personal experience with substance use—can help patients who use drugs feel more supported in the emergency department. The goal is to see if having peers available reduces the number of patients who leave before th…

This early-stage study at Yale University is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty adults will receive the drug in an open-label design (everyone knows…

This study tests a mobile app that rewards veterans with money when they prove they haven't smoked, helping them quit before and after major surgery. About 36 veterans scheduled for surgery will join. The goal is to see if this approach is practical and helps reduce smoking-relat…

This study tests a smartphone app designed to help teens and young adults (ages 14-35) with alcohol or cocaine use disorder. The app provides short training sessions to strengthen self-control when faced with substance-related cues. Researchers want to see if this approach is pra…

This study tests whether a gentle brain stimulation technique called tDCS can lower cravings in people with cocaine addiction. About 120 adults will receive the stimulation while doing thinking tasks, and brain scans will track changes. The goal is to see if this approach can hel…

This study tests whether an 8-week personalized occupational therapy program can help people with substance use disorder perform daily activities better, feel more confident, and bounce back from stress. About 34 adults who have completed detox will be split into a therapy group …

This study looks at three different ways to manage pain after childbirth in women who are on medication for opioid use disorder. The goal is to find which method works best for pain control and whether it also helps reduce anxiety, depression, and improve overall well-being. Abou…

This study tests whether music therapy can help people with substance use disorder reduce their addiction severity and improve their recovery. 600 adults from several European countries will be randomly assigned to active music-making, music listening, or standard treatment. The …

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their lifetime experiences with conditions like depression, …

This study follows 35 men in residential rehab for severe substance use. They write weekly stories about their feelings and challenges, and fill out questionnaires every two weeks. Researchers use natural language processing to analyze the stories and look for patterns that might…

This study follows 400 parents in rural Ohio who are part of the Ohio START program, which connects them to substance use treatment and peer mentors. Researchers want to see if having treatment services close to home and strong social support helps parents recover and improves th…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study looks at two different approaches to help pregnant and postpartum people get better mental health care. One approach focuses on improving care within doctor's offices, while the other partners with community groups. About 1,270 participants across 32 U.S. clinics will …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study aims to develop a new tool to measure outcomes in substance use disorder treatment. Researchers will interview patients, caregivers, and clinicians to identify key themes and create a questionnaire. The goal is to provide a more accurate way to assess treatment effecti…