Brain pacemaker could curb opioid cravings in hardest cases
NCT ID NCT07214467
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 35 times
Summary
This early study tests whether a personalized deep brain stimulation (DBS) device can safely reduce cravings and opioid use in people with severe, treatment-resistant opioid use disorder. Six adults will undergo brain mapping to identify targets linked to craving, then receive adaptive stimulation. The goal is to see if this approach is safe and shows promise for future larger trials.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
deep brain stimulation (DBS) device
What this could lead to
If it works, this could point toward a new brain-based treatment for people with severe opioid addiction who haven't improved with other therapies.
What could go wrong
This is a very early, small study with only 6 participants, so results may not apply to everyone. The procedure involves brain surgery, which carries risks like infection or bleeding.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.