SUBSTANCE USE DISORDER (SUD)

This study tests two digital treatment programs for substance use disorder in 20 adults recently released from Canadian prisons. Participants will use the programs for 6 months, and researchers will track how often they complete modules, whether they relapse, and if they return t…

This pilot study tests a personalized brain stimulation approach for people with severe addiction who haven't been helped by other treatments. Ten participants will first undergo detox, then have temporary electrodes placed in their brain to map addiction-related areas, followed …

This pilot study looks at two ways to help pregnant and postpartum people with substance use disorder stay in treatment. One approach screens for social needs like housing or childcare and connects patients to community help. The other uses small rewards to encourage recovery-sup…

This early study tests whether a personalized deep brain stimulation (DBS) device can safely reduce cravings and opioid use in people with severe, treatment-resistant opioid addiction. Six adults aged 22-75 who have used opioids for over 5 years will first undergo brain mapping t…

This study tests a long-acting injectable HIV prevention medication (cabotegravir) in 100 adults who inject drugs and are at risk for HIV. Participants receive the shot along with support services. The goal is to see if people stick with this prevention method over 7 months.

This study tests whether a gentle brain stimulation technique called tDCS can help people with cocaine addiction feel less craving. 120 adults with cocaine use disorder will receive tDCS sessions over 5 weeks while doing cognitive tasks. Researchers will use brain scans to see ho…

This study tests whether an 8-week personalized occupational therapy program can help people recovering from substance use disorder improve their ability to perform daily activities like work, self-care, and leisure. Researchers will measure changes in performance, satisfaction, …

This study tests three different ways to manage pain after childbirth in mothers who have opioid use disorder. Researchers want to see which method works best and whether better pain control also helps reduce anxiety, depression, and improve overall well-being. About 20 women age…

This study tests whether a single dose of psilocybin (25 mg) is safe and tolerable for people struggling with mood, anxiety, trauma, or addiction symptoms that affect daily life. Researchers at Yale will enroll 50 adults and follow them for up to 6 weeks, with optional longer fol…

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care clinics in Pakistan. Researchers will train 300 doctors in three major cities using a smartphone app and telemedicine. The goal is to f…

This study looks at 100 people with substance use disorders who want to quit smoking. Half will get a 6-week smoking cessation program, while the other half continues usual care. Researchers will test blood and stool samples to see how quitting affects gut bacteria and metabolism…

This study is developing and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to see if these videos can help prevent posttraumatic stress disorder (PTSD) and substance use. The study has two phases:…

This study aims to see if using a life history calendar helps people recall past mental health issues more accurately. Researchers will ask 2,500 adults in Hong Kong about their mental health, with half using a calendar as a memory aid. The goal is to improve how we measure lifet…

This study is testing a smartphone app designed to help young people aged 14 to 35 with alcohol or cocaine use disorder strengthen their self-control. Participants will use the app for short training sessions over a month, plus booster sessions. The goal is to see if the app is e…