SUBSTANCE USE DISORDER (SUD)

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests a program called TBI-RECOVER that screens for brain injury and provides special support in substance use treatment. About 900 adults in outpatient therapy will take part. The goal is to see if the program helps people stay in treatment longer and feel better.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests a cognitive behavioral therapy (CBT)-based psychoeducation program for 44 adults diagnosed with substance use disorder. The goal is to see if the program reduces feelings of social exclusion and hopelessness, and improves their ability to cope with relapse. Parti…

This study tests a program called ADD'Pro that combines addiction treatment with personalized job counseling to help people with substance use disorders return to work. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. Resea…

This early-phase study will give 144 healthy young adults (ages 18-21) a single dose of THC (7.5 mg) or a placebo capsule, then measure their brain activity using fMRI and track their mood and behavior. The goal is to understand why some people respond differently to cannabis, wh…

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study looks at how people recover from substance use disorders while living in therapeutic communities in Mexico. Researchers will track 60 adults over 8 to 12 weeks using surveys and daily check-ins to understand what helps them stay in treatment and avoid relapse. The goal…

This study will test two new services at a large Chicago health center: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction care. The goal is to find more people with undiagnosed HIV or subs…

This study looks at the best ways to get family members involved in supporting a loved one who is getting treatment for substance use disorder. Researchers will test different strategies to see which ones are most helpful and easy for families to use. About 100 family members and…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study looks at how a brief writing therapy called Written Exposure Therapy (WET) works for people with both PTSD and substance use disorders who are in residential treatment. About 108 participants will either do WET or neutral writing alongside their usual care. Researchers…

This study tests a new program for adults in prison who have both ADHD and substance use disorder. The program includes workshops to improve care and support. Researchers will check if the program is acceptable and if it improves quality of life.

This study tests if a special job training program helps people with substance use disorder recover better. About 50 adults in West Virginia who are in a day report program will either get the job training or standard help. Researchers will check if the training improves their re…

This study looks at how communities can better use deflection programs—which guide people with substance use toward treatment instead of arrest. Researchers will test two community engagement strategies across 20 communities in five states. The goal is to see which approach impro…