SUBSTANCE USE DISORDER (SUD)

This study is testing a new peer-led support group called the TLC Program, designed by and for transgender adults. It aims to help transgender women who use substances or are in recovery by teaching mindfulness skills to cope with stress and stigma, with the goal of reducing subs…

This study aims to find the best way to help pregnant and postpartum people get care for anxiety and depression. It will compare two approaches across 32 healthcare sites: one focuses on improving care within clinics, while the other adds a community-based peer support program. T…

This pilot study is testing two practical strategies to help pregnant and postpartum people stay engaged in treatment for substance use disorder. The first strategy involves screening for basic needs like housing and transportation and connecting people to community support servi…

This study is testing whether a smartphone app can help young people (ages 14-35) who are already in treatment for alcohol or cocaine use disorder. The app provides short brain-training games designed to strengthen a person's ability to ignore or resist substance-related cues and…

This early research study is testing whether a personalized brain stimulation device can help people with severe opioid addiction who haven't responded to standard treatments. Researchers will first map brain activity to identify craving signals, then use an implanted device to d…

This study is testing whether a support program helps people connect to regular doctors after leaving prison. It focuses on adults with a history of substance use and chronic health conditions. Researchers will compare if weekly check-in calls from a nurse case manager lead to mo…

This is a small pilot study to see if a new support program is practical and acceptable for people living with HIV who also use substances. The program aims to help participants stick to their HIV medication, manage substance use, and stay engaged with their healthcare. Researche…

This pilot study tests whether two digital treatment programs can help people recently released from prison manage substance use problems and avoid returning to jail. Researchers will follow 20 participants for 6 months to see if they use the programs and whether they relapse or …

This large international study is testing whether adding group music therapy to standard addiction treatment helps people with substance use disorders. It will compare two types of music-based activities—active music-making and music listening—against usual care alone. The main g…

This study is testing if hiring peer support workers—people with personal experience using drugs—in a busy emergency room can help patients who use substances feel safer and more comfortable. The goal is to see if this support encourages patients to stay and complete their medica…

This study is testing whether a combination of gentle brain stimulation and mental training can help people with cocaine addiction reduce their cravings. Researchers will enroll 120 adults with cocaine use disorder to receive either real or fake stimulation while practicing techn…

This study is testing a new mobile app program designed to help Veterans quit smoking before and after major elective surgery. Smoking around surgery greatly increases risks like infections, longer hospital stays, and even death. The program uses financial rewards to motivate par…

This study is testing video programs designed to prevent post-traumatic stress disorder (PTSD) and substance use problems in teenagers who have been seriously injured. Researchers are working with 62 parent-teen pairs at a pediatric trauma center to develop and test these educati…

This study is testing a support program for men recently released from jail or prison who are at risk for HIV and substance use problems. The program uses trained peer mentors, a smartphone app, and small incentives to help participants get HIV prevention medication (PrEP), testi…

This study tests whether group therapy for trauma (PTSD) given in prison helps people after release. It compares group therapy to a self-help workbook to see which better reduces drug use, PTSD symptoms, and re-arrests. About 640 incarcerated adults with trauma and drug use histo…

This study is testing three different methods to control pain after birth for people who are taking medications for opioid use disorder. It aims to find which approach works best for pain relief and if it also helps reduce feelings of anxiety and depression. The study will involv…

This early-stage study from Yale University is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and tolerable for people whose daily lives are impacted by symptoms of depression, anxiety, trauma, or addiction. The study will enroll 50…

This study is testing whether a personalized 8-week occupational therapy program can help people recovering from substance use disorder. The therapy focuses on improving daily life skills like work, self-care, and managing time to build confidence and resilience. Researchers will…

This study is testing whether a new digital training program is practical and acceptable for primary care doctors in Pakistan. The program is based on a World Health Organization guide and teaches doctors how to better help patients with substance use disorders. The research will…

This study aims to see if using a visual life history calendar helps people in Hong Kong remember their mental health history more accurately. Researchers will compare the standard mental health interview with and without the calendar tool. The goal is to improve how we measure h…