SUBSTANCE USE DISORDER (SUD)

This study tests two digital treatment programs for substance use in 20 adults recently released from Canadian prisons. Participants use the programs for 6 months, and researchers track how often they complete modules, whether they relapse, and if they return to prison. The goal …

This study is testing a new mutual-help group called the TLC Program for transgender adults who use substances or are recently in recovery. The program uses mindfulness and values-based counseling to improve mental health and reduce HIV risk. Researchers will enroll 124 participa…

This study tests a smartphone-based program that gives veterans small rewards for staying smoke-free before and after major elective surgery. Smoking raises the risk of problems like infections and longer hospital stays after surgery. The program uses breath tests to confirm abst…

This study looks at two ways to help pregnant people and new mothers with substance use disorder stay in treatment. One way is to screen for social needs like housing or childcare and connect them to community help. The other uses small rewards to encourage healthy behaviors. The…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. About 640 incarcerated adults from 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests whether a personalized deep brain stimulation (DBS) device can safely reduce cravings and opioid use in people with severe, long-term opioid addiction that hasn't improved with other treatments. Six adults aged 22-75 will undergo brain mapping to identify craving…

This study tests a program to help people with HIV and substance use stick to their HIV medications and stay engaged in care. The program focuses on coping skills, managing substance use, and improving HIV care habits. About 50 adults with HIV who have used substances like cannab…

This study tests a program called MEPS that uses a mobile app, peer mentors, and small rewards to help people recently released from jail get HIV testing, PrEP (a daily pill to prevent HIV), and substance use treatment. About 300 people in California will take part. The goal is t…

This study aims to see if a long-acting injectable HIV prevention drug (cabotegravir) works well for adults who inject drugs. 100 participants will receive the shot along with support services. The main goal is to see how many people stick with the treatment for 7 months.

This study is testing two short videos designed to help teens and their parents cope after a traumatic injury. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. About 92 teens aged 12-17 and their parents will watch the videos and complete surveys ove…

This study tests whether an 8-week person-centered occupational therapy program can improve daily activities, self-confidence, and resilience in people recovering from substance use disorder. About 34 adults who have completed detox will be split into a therapy group and a contro…

This study tests whether a gentle brain stimulation technique called tDCS can reduce cravings in people with cocaine addiction. 120 adults will receive the stimulation while doing cognitive tasks, and brain scans will measure changes. The goal is to develop a tool patients can us…

This study looks at three different ways to manage pain after childbirth in women who are being treated for opioid use disorder. The goal is to find which method works best for pain, and whether it also helps reduce anxiety, depression, and improve overall well-being. About 20 wo…

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study tests whether music therapy can help people with substance use disorder reduce their addiction and improve their lives. 600 adults from several European countries will either join active music groups, listen to music, or receive standard treatment. Researchers will mea…

This study looks at two different approaches to help pregnant and postpartum people get better mental health care. About 1 in 5 experience anxiety or depression during this time. The study will involve 1,270 participants across 32 clinics in the U.S. to see whether a healthcare-o…

This study aims to create a new tool to measure the consequences of substance use in people with substance use disorder. Researchers will interview patients, their close friends or family, and healthcare providers to develop the tool. The goal is to better understand and track tr…

This study follows 400 rural families in Ohio START to see if nearby treatment services and peer mentors help parents recover from substance use and improve child well-being. Participants answer surveys and share their daily locations and social connections over a year. The goal …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used by primary care doctors in Pakistan. 300 doctors from cities and rural areas will be trained using the app. The goal is to check if this approach is practical and …

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people with substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with psychological…

This study looks at whether having peer support workers—people who have personally used drugs—in the emergency department can make patients who use drugs feel more comfortable and less likely to leave before their treatment is done. About 3,181 adults visiting the ER at Vancouver…

This study tests whether a short program with a nurse case manager helps people leaving prison attend more regular doctor visits instead of going to the emergency room. About 488 adults with substance use history and chronic health conditions will be split into two groups: one ge…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study is testing whether a smartphone app can help young people aged 14 to 35 with alcohol or cocaine use disorder by training their brain to say "no" to substance-related cues. Participants will use the app for short training sessions over a month, plus booster sessions. Th…