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Can breathing exercises help veterans heal from trauma and addiction?

NCT ID NCT07756723

Disease control Sponsor: Coatesville VA Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial tests whether heart rate variability biofeedback (HRVB) — a technique that uses guided breathing to improve the body's stress response — can help veterans with both PTSD and substance use disorder. Participants will be randomly assigned to receive either HRVB or present-centered therapy, a talk therapy focusing on current life challenges. The study will measure changes in PTSD symptoms, substance use, and physiological markers like heart rate and skin conductance. The goal is to see if HRVB offers a unique benefit for this high-risk population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Heart rate variability biofeedback (a technique that uses breathing to improve heart rhythm regulation) compared with present-centered therapy (a talk therapy focused on current life issues)
What this could lead to
If effective, this could offer veterans with PTSD and substance use disorder a new, drug-free way to reduce symptoms and improve heart health, potentially lowering their risk of early death.
What could go wrong
This is a relatively small trial (50 participants) and early-stage, so results may not apply broadly. The biofeedback may not outperform the control therapy, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * PTSD diagnosis * Enrolled in VA healthcare * Attending residential programming at CVAMC * Current substance use difficulty based on screening questions Exclusion Criteria: * Non-English speaking * Inability to complete study procedures * Lack competency to provide consent * Acute intoxication of a substance * Active psychotic symptoms at the study visit * Suicidal or homicidal ideation with intent and planning * Pacemaker or other cardiovascular implants.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Posttraumatic stress disorder (PTSD) Substance use disorder (SUD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Coatesville VA Medical Center

    RECRUITING

    Coatesville, Pennsylvania, 19320, United States

More trials for these conditions

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