SLEEP APNEA

This study tests a device called the Lunair Alpha System, a neurostimulator implant that aims to treat moderate to severe sleep disordered breathing. It is for people who cannot use or do not tolerate other treatments like CPAP machines. The trial will check if the device is safe…

This study is testing a new device called the remedē Dual Channel System for people with severe sleep apnea. The device is implanted in the body and uses mild electrical stimulation to keep the airway open during sleep. The study will enroll 40 participants to see if the device i…

This study tests a culturally tailored sleep program for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The program includes three telehealth sessions to teach sleep skills and support. Researchers want to see if it improves CPAP use and sleep qual…

This registry follows 225 adults with moderate to severe obstructive sleep apnea who cannot use standard CPAP machines. They receive an implanted device that stimulates a nerve to keep the airway open during sleep. The study measures how well the device reduces breathing pauses a…

This study tests whether a sleep medication called eszopiclone can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. About 250 adults with a new sleep apnea diagnosis will receive either eszopiclone or a placebo f…

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study looks at whether oxygen, finasteride, or acetazolamide can help reduce sleep apnea in adults aged 60 and older with mild to moderate sleep apnea. Researchers will measure breathing stability and sleep quality. The goal is to find new, effective treatments for elderly V…

This study tests whether bexagliflozin, a drug typically used for diabetes, can reduce the severity of sleep apnea in overweight or obese adults. About 164 participants will receive either the drug or a placebo for 6 months, along with routine care. Researchers will measure chang…

This early-phase study tests whether an oxytocin nose spray can lower the air pressure needed from a CPAP machine during sleep, potentially reducing side effects from low oxygen in people with obstructive sleep apnea. About 40 adults will take part over 35 nights, including three…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep, which can affect how well a shunt (a tube that drains fluid from the brain) works. Researchers will study 30 adults with normal-pressure hydrocephalus to see if measuring these pressures hel…

This study looks at whether checking for sleep apnea at home can help people with atrial fibrillation feel better. About 936 adults with AF will either be tested for sleep apnea and treated if needed, or not tested at all. Researchers will track symptoms, activity, and heart rhyt…

This study looks at whether a daytime sleep test can work as well as an overnight one for adjusting the Inspire device, which treats obstructive sleep apnea. About 110 people who already have the Inspire implant will take part. The goal is to see if daytime testing is just as goo…

This study will follow 1,000 adults referred to sleep clinics with suspected obstructive sleep apnea. Participants undergo sleep testing, blood pressure monitoring, and questionnaires over two years. The goal is to gather data on diagnosis, symptoms, and treatment adherence to im…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…