SLEEP APNEA

This registry follows 225 adults with moderate to severe obstructive sleep apnea who cannot use standard CPAP machines. They receive an implanted device that stimulates a nerve to keep the airway open during sleep. The study measures how well the device reduces breathing pauses a…

This study tests a device called the Lunair Alpha System for people with moderate to severe sleep apnea who cannot use standard treatments like CPAP. The device is implanted and stimulates nerves to improve breathing during sleep. The trial will check if it is safe and effective …

This study looks at whether a sleep medication (eszopiclone) can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will study 250 adults with sleep apnea to see if raising the brain's arousal threshold…

This study tests a new device called the remedē Dual Channel System for people with severe sleep apnea. The device is implanted in the body to help keep breathing steady during sleep. The study will check if the implant is safe and if it can reduce breathing problems during sleep…

This study tests whether screening for sleep apnea at home can improve quality of life for people with atrial fibrillation (an irregular heartbeat). About 936 participants will either be tested for sleep apnea and treated if needed, or not tested at all. Researchers will track sy…

This study tests whether bexagliflozin, a drug typically used for diabetes, can reduce the severity of sleep apnea in overweight or obese adults. About 164 participants will receive either the drug or a placebo for 6 months, along with routine care. Researchers will measure chang…

This study tests a culturally adapted program called Nuestro Sueno for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The goal is to see if the program helps the patient use CPAP more consistently and improves sleep quality for both partners. Resea…

This pilot study tests whether breathing air with slightly higher carbon dioxide (hypercapnia) for two weeks can improve breathing and reduce sleep apnea in veterans with spinal cord injury. About 30 participants will be enrolled to see if this approach is feasible and helps with…

This study is for Veterans aged 60 and older with mild to moderate sleep apnea. Researchers want to see if three treatments—oxygen, finasteride, and acetazolamide—can help stabilize breathing during sleep. The goal is to find new, effective ways to improve sleep and overall healt…

This study tests treatments for sleep apnea in 100 adults with chronic cervical spinal cord injury (more than 3 months since injury). The goal is to improve breathing during sleep by measuring changes in lung volume, carbon dioxide levels, and apnea severity. Participants must be…

This early-phase study tests whether an oxytocin nose spray can lower the air pressure needed from a CPAP machine during sleep, potentially reducing side effects from low oxygen in people with obstructive sleep apnea. About 40 adults will take part over 35 nights, including three…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study will follow 1,000 adults who are referred to a sleep clinic with possible sleep apnea. Participants will have a sleep test, blood pressure monitoring, and complete questionnaires about sleepiness and quality of life. Those diagnosed with sleep apnea will receive usual …

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep, which can affect how well a cerebrospinal fluid shunt works. Researchers will measure these pressures in 30 people with normal-pressure hydrocephalus to decide whether to drain fluid into th…

This study looks at whether a daytime sleep test works as well as an overnight one to adjust the Inspire device for people with obstructive sleep apnea. About 110 adults who already have the Inspire implant will take part. The goal is to see if daytime testing can save time and r…