SKIN CANCER

This study is for people with advanced head and neck cancer that has come back or spread. It tests a special device placed directly into the tumor that gives off a unique type of radiation (alpha rays) combined with an immunotherapy drug called pembrolizumab. The goal is to see i…

This study tests a new device that delivers a special type of radiation (alpha rays) directly into tumors on the skin, inside the mouth, or in soft tissues. The goal is to see if it can shrink or control these cancers and to check for side effects. About 30 adults with tumors up …

This study tests a treatment made from your own immune cells (called TILs) that were found inside your tumor. These cells are multiplied in a lab and given back to you along with chemotherapy and a drug called IL-2. The goal is to see if this combination is safe and can shrink tu…

This study tests a drug called atezolizumab in about 200 adults with advanced solid tumors (like breast, lung, or colon cancer) whose tumor DNA suggests the drug might help. Participants get the same dose every 3 weeks, and researchers check if their cancer shrinks or stops growi…

This study tests a new experimental drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The main goal is to check the drug's safety and find the right dose. About 80 adults will take part in two p…

This early-phase study tests a new drug, ONM-501, injected directly into tumors, either alone or with another drug (cemiplimab), in people with advanced solid tumors or lymphomas that have not responded to other treatments. The main goals are to find the safest dose and understan…

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two immunotherapy drugs (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if…

This study tests whether using fractional lasers followed by tirbanibulin ointment can effectively treat two common types of skin cancer: squamous cell carcinoma and basal cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and the…

This study tests whether freezing part of a growing tumor (cryoablation) combined with two immunotherapy drugs (ipilimumab and nivolumab) can help control advanced melanoma that stopped responding to prior treatment. About 37 adults with unresectable melanoma will receive the com…

This study looks at whether high-intensity exercise and a high-fiber diet are possible and helpful for people with advanced melanoma who are receiving immunotherapy. The goal is to see if these lifestyle changes can improve gut health and immune function. The study will involve 4…

This study is testing whether a telemedicine tool can help primary care doctors find skin cancer earlier. About 1,440 people with suspicious moles or light skin types will have their skin lesions photographed and reviewed remotely by a dermatologist. The goal is to see if this ap…

This study tests whether an AI system called Dermalyser can help primary care doctors better identify skin cancer. About 3000 adults with suspicious skin lesions will take part across 30 clinics in 5 countries. Doctors will either use the AI or follow standard care, and patients …

This early-stage trial tests whether taking vitamin A and nicotinamide (a form of vitamin B3) can help prevent skin cancer in kidney transplant recipients who have already had skin cancer. The study will enroll 30 adults and measure changes in blood vitamin levels to see if the s…

This study looks at whether giving people personalized information about their skin cancer risk can encourage them to protect themselves from the sun. About 2,900 adults from community health centers will receive different types of risk messages and be followed for a year. The go…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at whether a single dose of meloxicam (a pain reliever) can control pain better than the usual ibuprofen after Mohs surgery for skin cancer. About 300 adults will be split into three groups: one gets a low dose of meloxicam, one gets a higher dose, and one gets s…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. Researchers will measure changes in food security, di…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors, plus healthy volunteers, to see if the test helps predict when cancer comes back. …

This study is for people with a type of skin cancer called cutaneous squamous cell carcinoma who are waiting to have surgery to remove the tumor. Researchers want to see if injecting the seasonal flu vaccine directly into the tumor can attract more immune cells to fight the cance…

This study collects tumor samples from 2,000 people with various cancers to learn how to predict who will respond to immunotherapy. Participants donate tissue during a routine biopsy. The goal is to understand tumor biology and improve future treatment decisions, not to test a ne…

This study tests whether a personalized discharge letter helps low-risk skin cancer patients feel more reassured and understand their condition better. About 150 patients will receive either standard advice or a tailored letter generated by an AI and reviewed by a doctor. The goa…

This study looks at why some people get sick from heat and sun while others don't. Researchers will test 80 healthy adults from Denmark and Greece by exposing them to controlled heat and UV light. The goal is to create personalized alerts and advice to help people stay safe durin…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study looks at blood samples from 20 people with melanoma or other skin cancers to see if certain markers in the blood can predict how well treatment works or how long patients live. Participants give blood during their regular care. The goal is to find better ways to monito…

This study tests if a special laser probe (Raman spectroscopy) can measure how far skin cancer spreads. About 20 adults with basal or squamous cell skin cancer will have their tumors scanned with the probe. The goal is to see if the laser can tell the difference between cancer an…

This study looks at how electrochemotherapy—a treatment that uses electric pulses to help chemotherapy drugs enter tumor cells—changes the environment around melanoma skin tumors. Researchers will collect tissue samples from 150 adults with melanoma before and after treatment to …

This study is looking at how effective immunotherapy is as a first treatment for metastatic melanoma that has spread. Researchers will check if a marker called PD-L1, found in tumors and blood, can help predict who will respond well. About 100 adults with advanced melanoma will t…