RETINITIS PIGMENTOSA

This study tests a gene therapy called BS01 for people with retinitis pigmentosa, a genetic condition that causes gradual vision loss. The therapy uses a harmless virus to deliver a light-sensitive protein to remaining eye cells, aiming to help them detect light again. The trial …

This early-stage trial tests whether an injection called ZM-02 is safe for people with retinitis pigmentosa, a genetic condition that causes vision loss. Twelve participants with very poor vision will receive one injection in one eye. The main goal is to check for side effects, n…

This study tests the safety of a single injection of lab-grown retinal sheets (made from stem cells) into one eye of adults with retinitis pigmentosa, a genetic condition that causes progressive vision loss. Twelve participants will be split into three groups based on their curre…

This study tests an experimental drug called KIO-301, given as an eye injection, for people with late-stage retinitis pigmentosa—a disease that causes vision loss. The trial includes 36 adults who have no light perception or very low vision. Participants will receive up to three …

This study tests a new retinal implant (AuTNA I) in 7 adults with retinitis pigmentosa, a genetic eye disease that causes vision loss. The implant is placed under the retina and aims to safely improve light sensitivity and vision. Researchers will check safety and measure any vis…

This study tests a one-time gene therapy injection into the eye for people with advanced retinitis pigmentosa caused by mutations in the RHO, PDE6A, or PDE6B genes. The goal is to see if it is safe and can slow vision loss. About 33 adults will take part, and the study will follo…

This study tests the safety of a single injection of jCell, made from retinal cells, in 60 adults with retinitis pigmentosa, a genetic eye disease that causes vision loss. Participants are randomly assigned to get the real injection or a sham procedure. The main goal is to check …

This early-phase study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration. Researchers believe it may reduce harmful activity in the retina. The study involves 15 adults with inherited retinal disease …

This study collects skin, hair, blood, saliva, or urine samples from people with certain eye diseases (like macular degeneration) and healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new drugs…

This study uses a special camera to take extremely detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers want to see how individual cells differ between healthy eyes and eyes with diseases like Stargardt's or age-related macular degenerati…

This study looks at how well people see in the dark to learn more about retinal diseases like retinitis pigmentosa and Stargardt's disease. Researchers will compare healthy volunteers and people with retinal disease to see if dark adaptation tests can detect and track disease sev…

This registry collects health information from people with inherited retinal diseases to help researchers better understand these conditions. Participants create an online profile and can update it over time. The goal is to speed up research and connect people with clinical trial…

This study is for people with severe vision loss from diseases like retinitis pigmentosa or Stargardt disease. The goal is to find out which vision tests work best for people with very low vision, so future treatments can be measured more accurately. About 25 participants will tr…

This study follows 45 adults with retinitis pigmentosa caused by EYS gene mutations to learn how the disease naturally changes over 4 years. Researchers will measure vision and eye function to find the best ways to track the disease in future treatment trials. The goal is to help…

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand eye diseases. About 1,200 people with various eye conditions or healthy …

This study uses a special camera called adaptive optics to take detailed pictures of the back of the eye in people with outer retinal diseases, such as age-related macular degeneration and retinitis pigmentosa. The goal is to develop new ways to diagnose and track these diseases.…

This study is for people with rare inherited retinal diseases like retinitis pigmentosa. It has two parts: a registry that collects genetic and vision information, and a natural history study that follows vision changes over time. No new treatments are tested—the goal is to bette…