RESPIRATORY INSUFFICIENCY

This study looks at whether a sedative called dexmedetomidine is better than a placebo for older patients (65+) who are on breathing machines in the ICU. The goal is to see if it can reduce deaths, time on the ventilator, and confusion. About 300 patients will take part, and neit…

This study tests whether starting breathing support (non-invasive ventilation) early can help people with ALS who are not yet severely weak. Researchers will use a tool to predict who is at high risk of breathing problems within 6 months. 48 participants will either start early v…

This study tests whether using a high-flow nasal cannula (a device that delivers warm, moist oxygen) for 24 hours right after major abdominal surgery can prevent serious lung complications like pneumonia or collapsed lungs. About 580 adults having long abdominal surgeries will be…

This study tests whether an improved non-invasive ventilation (NIV) mask can lower how often people need to breathe compared to a standard mask. About 60 adults who already use NIV for respiratory problems will try both masks for one hour each. Researchers will measure breathing …

This study tests a procedure called cryoablation, which uses cold to temporarily freeze nerves around broken ribs. The goal is to reduce severe pain, improve breathing, and prevent complications like pneumonia. About 30 adults with multiple rib fractures will be randomly assigned…

This study looks at a new way to decide how to close the belly wall during large hernia repair to prevent breathing problems after surgery. Doctors will use standard breathing measurements taken during the operation to guide their closure choice. The study will track how many of …

This study looks at how different levels of pressure from a breathing machine (ventilator) affect the lungs and diaphragm in 25 ICU patients with respiratory failure. Each patient will try three pressure settings to see which one helps them breathe more efficiently and with less …