PULPITIS
Clinical trials for PULPITIS explained in plain language.
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New hope for tooth pain: less invasive therapy matches root canal success
Disease control CompletedThis study tested whether a less invasive treatment called vital pulp therapy (VPT) works as well as standard root canal treatment for people with severe, irreversible tooth pulp inflammation. 43 adults with painful back teeth took part, and after 12 months, both treatments had s…
Matched conditions: PULPITIS
Phase: NA • Sponsor: Universidad Central de Venezuela • Aim: Disease control
Last updated May 26, 2026 06:39 UTC
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Light therapy may soothe root canal pain, study finds
Symptom relief CompletedThis study looked at whether using a special light treatment (photodynamic therapy) during root canal cleaning can reduce pain afterward. 95 adults with infected back teeth were treated, and their pain was tracked for 3 days. The goal was to see if adding light therapy helps more…
Matched conditions: PULPITIS
Sponsor: Atlas University • Aim: Symptom relief
Last updated May 26, 2026 06:38 UTC
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Chill out: cold therapy may ease dental pain after root canals
Symptom relief CompletedThis study tested whether applying cryotherapy (cold therapy) during pulpotomy or root canal treatment reduces pain and improves quality of life for people with deep cavities. 144 adults with deep decay in a molar were randomly assigned to receive either standard treatment or tre…
Matched conditions: PULPITIS
Phase: NA • Sponsor: Ondokuz Mayıs University • Aim: Symptom relief
Last updated May 26, 2026 05:51 UTC
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AI helps dentists save infected teeth without root canals
Symptom relief CompletedThis study tested whether a less invasive dental procedure (full pulpotomy) works as well as a root canal in molars with severe infection. 58 adults with irreversible pulpitis were treated, and an AI tool helped detect hidden infections on X-rays. The goal was to see if the tooth…
Matched conditions: PULPITIS
Phase: NA • Sponsor: Misr International University • Aim: Symptom relief
Last updated May 13, 2026 16:03 UTC
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Tooth pain and stress: scientists find chemical link
Knowledge-focused CompletedThis study looked at 72 adults with and without tooth pain to measure certain nerve chemicals (substance P and CGRP) in their saliva and tooth pulp. The goal was to see how these chemicals relate to pain severity, tooth inflammation, and psychological factors like anxiety and str…
Matched conditions: PULPITIS
Sponsor: Kahramanmaras Sutcu Imam University • Aim: Knowledge-focused
Last updated May 26, 2026 06:39 UTC
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Tooth inflammation study seeks biomarkers to tell reversible from irreversible damage
Knowledge-focused CompletedThis completed study looked at 51 people with healthy teeth, reversible pulpitis (mild inflammation), or irreversible pulpitis (severe inflammation). Researchers measured three inflammation-related proteins (IL-8, FGF-1, and VEGF) in tooth pulp, gum fluid, and dentin fluid. The g…
Matched conditions: PULPITIS
Sponsor: Kırıkkale University • Aim: Knowledge-focused
Last updated May 20, 2026 11:55 UTC