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New Tooth-Saving technique could replace root canals

NCT ID NCT07355140

Disease control Sponsor: Universidad Central de Venezuela Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a less invasive treatment called vital pulp therapy against standard root canals for teeth with severe pulp inflammation. In the new approach, dentists removed only the inflamed pulp and placed a natural blood-derived material (PRF) to help the tooth heal. Forty-three adults completed the 12-month follow-up. The goal was to see if the tooth could stay alive and healthy without needing a full root canal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich fibrin (PRF) and bioceramic putty
What this could lead to
If successful, this could offer a less invasive alternative to root canals, preserving more of the natural tooth.
What could go wrong
This is a small, completed trial with only 43 participants, so results may not apply to everyone. The procedure may fail if inflammation persists.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

43 people

The number who actually took part.

Started

Jan 2021

Finished

Nov 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

26 to 61 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Posterior teeth with closed apices. * Deep carious lesions radiographically close to the pulp. * Symptoms of symptomatic irreversible pulpitis (spontaneous and/or sharp pain, localized or referred, provoked and persistent to thermal stimuli). * Teeth restored with direct restorations. Exclusion Criteria: * Subgingival caries or restorations. * Moderate or severe periodontitis. * Internal or external resorption. * Calcification of the pulp chamber or root canals. * Uncontrolled pulpal bleeding within 15 minutes.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpitis Pulpitis - irreversible Pulpotomy Root canal therapy

Contacts and locations

Locations

  • Central University of Venezuela

    Caracas, DC, 1050, Venezuela

More trials for these conditions

Other studies related to the condition(s) this trial covers.