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Tooth inflammation biomarkers measured in new study

NCT ID NCT06936553

Knowledge-focused Sponsor: Kırıkkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 51 people to compare levels of three substances (IL-8, FGF-1, and VEGF) in teeth that are healthy, mildly inflamed, or severely inflamed. Samples were taken from the tooth pulp, gum fluid, and dentin fluid during routine root canal treatment. The goal was to see if these markers can help tell the difference between healthy and inflamed teeth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

51 people

The number who actually took part.

Started

Mar 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will include patients aged between 16-60 years who presented to Kırıkkale University, Faculty of Dentistry, Department of Endodontics with the indication of root canal treatment and were diagnosed with healthy pulp status (Group 1), symptomatic irreversible pulpitis (Group 2) and asymptomatic reversible pulpitis (Group 3).

Ages

16 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Control group: * Unrestored, caries-free vital teeth with healthy pulp * Orthodontically indicated teeth for extraction * wisdom teeth indicated for extraction in terms of oral hygiene * teeth that require root canal treatment for prosthetic purposes Reversible pulpitis group: * Teeth that react mildly to cold, hot, sour or sweet stimuli * Teeth with no history of spontaneous pain * Teeth that respond to cold test and electric pulp test within normal limits * Teeth that are not sensitive to chewing or percussion Irreversible pulpitis group: * Teeth with a history of continuous moderate or severe spontaneous pain * Teeth sensitive to percussion * Teeth without periapical pathology Exclusion Criteria: * Patients requiring antibiotic prophylaxis. * Patients with diabetes or haematological diseases. * Patients who have used antibiotics or anti-inflammatory drugs in the last three weeks. * Patients who are pregnant during treatment. * Patients with intense plaque and tartar on their teeth, redness and bleeding in the gums. * Patients with severe gingivitis, generalised periodontitis or periodontal pocket depth of more than 3 mm. * Patients with no response to pulp sensitivity tests, presence of sinus tract, presence of periapical pathology on radiography. * Teeth without pulp exposure after caries removal

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biomarkers Healthy pulp Pulp inflammation Pulpitis Reversible pulpitis

Contacts and locations

Locations

  • Kırıkkale University Faculty of Dentistry

    Kirikkale, 71450, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.