PSYCHOLOGICAL DISTRESS

This study tests whether a free online program from the World Health Organization, called Doing What Matters in Times of Stress, can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with elevated stress will either get t…

This study tests whether adding extra support sessions to a standard mental health program helps refugees and asylum seekers feel less distressed and integrate better. About 1200 participants in Switzerland will receive the program, which is delivered by trained non-professionals…

This study tests whether very small, non-hallucinogenic doses of psilocybin (the active ingredient in 'magic mushrooms') can reduce depression, anxiety, and loss of purpose in people with advanced illnesses like cancer. 120 adults receiving palliative care will take either a dail…

This study tests a short counseling program for young adults (ages 25-39) with cancer and their caregiving partners. The goal is to see if the program helps them cope with stress and maintain their relationship. The study will enroll 20 couples and measure how many people join an…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty terminally ill patients will receive either two doses of LSD or a very low-dose active placebo. The goal is to improve psycholog…

This study tests a therapy called EMDR to help people with advanced thyroid cancer who also have PTSD. The therapy combines group and individual sessions to reduce stress and trauma symptoms. Researchers will enroll 25 participants to see if this approach is helpful and practical…

This study tests whether a therapy called Mindful Self-Compassion (MSC) can help people with borderline personality disorder (BPD) reduce self-harm, manage emotions better, and improve their quality of life. The study will involve 60 adults diagnosed with BPD who are not hospital…

This study tests whether a 10-day meditation app can lower anxiety and depression in firefighters. About 192 career firefighters will use pre-recorded audio sessions on their smartphones. The goal is to see if this simple, at-home tool can ease the mental strain of their demandin…

This study looks at whether a 12-session heart rate variability biofeedback program can help members of the Portuguese National Republican Guard feel less distressed and burned out, and improve their overall well-being. About 50 participants will learn breathing techniques and us…

This study tests a therapy called EMDR Toolbox to see if it can improve the emotional well-being of people with cancer. The therapy helps process past stressful events that may make coping with cancer harder. Researchers will enroll 46 adults with early-stage cancer and compare t…

This study is creating and testing a support program for Black transgender women who experience ongoing stigma. The program is designed with help from the community to reduce symptoms of distress, like PTSD and depression. About 40 participants will try the program to see if it i…

This study tests a short, guided self-help program called Self-Help Plus for university students who are behind on at least 3 exams and feeling significant distress. About 210 students will be randomly assigned to the program or usual support. The goal is to see if the program re…

This study tests whether a special, soothing way of talking called hypnotic communication can help patients feel less anxious and stressed during a heart catheterization. About 306 adults will be randomly assigned to receive either this calming talk plus usual care, or usual care…

This study is testing a smartphone app powered by artificial intelligence to help people with oral cancer return to work and manage physical and emotional challenges. Researchers will compare 650 patients who use the app with those who receive standard care. The goal is to see if…

This study looks at whether community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to see if this approach works in real-wo…

This study tests a digital program called Flourish that aims to prevent suicide in teens who have been cyberbullied. About 20 middle and high school students will use the program for 12 weeks. Researchers want to see if schools can easily offer it and if it helps reduce distress …

This study looks at how many adults with type 2 diabetes experience severe emotional distress related to their condition. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their feelings, quality of life, and diet. The goal is to understa…

This study follows 2,000 adults with various cancers to see if psychological distress (like anxiety or depression) impacts how well they stick to treatment, their health outcomes, and their quality of life. Participants complete questionnaires and are tracked for 3 years. The goa…

This study tests a digital program called Flourish designed to help teens aged 12-17 who have been cyberbullied and are at risk for suicide. About 80 teens will either use Flourish plus answer questionnaires or just answer questionnaires alone. Researchers want to see if the prog…

This study looks at how to make the removal of brachytherapy implants more comfortable and less distressing for women being treated for gynecologic cancer. Researchers will track PTSD symptoms and side effects in 36 participants. The goal is to find better ways to support patient…

This observational study follows 340 people receiving psychotherapy for common mental health problems in Ecuador. Participants fill out short well-being questionnaires before their regular therapy sessions. The goal is to understand how much distress typically changes and what fa…