Psychological distress

This trial tests whether giving a combination of clonazepam, olanzapine, and buprenorphine for just two days can quickly relieve the intense emotional distress of Suicide Crisis Syndrome in hospitalized adults. Participants are randomly assigned to receive one, two, or three of t…

This study tests whether a music group can help children aged 3-10 who have lived in shelters after domestic violence. The group sessions, led by musicians and a music therapist, aim to improve children's ability to recognize and manage emotions and build relationships. Researche…

This study tests whether a daily drink of freeze-dried grape powder can reduce anxiety, depression, and stress in healthy college students aged 18-30. Over 4 weeks, 50 participants will take either the grape powder or a placebo and complete surveys and stool tests. The goal is to…

This study compares two types of talk therapy—Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT)—for HIV/AIDS patients experiencing psychological distress. 72 adults on antiretroviral therapy will receive 8 weekly sessions of either therapy or standard…

This study tests a 7-session, peer-led self-management program for 234 cancer survivors who recently finished treatment with curative intent. The program aims to reduce anxiety and depression by teaching symptom management skills in a group setting. Participants are from central …

This study tests a stepped care approach to reduce depressive symptoms in 600 adolescents aged 13-15 from 40 schools in Rawalpindi, Pakistan. First, all students receive a universal intervention delivered by non-specialists. Those who still have symptoms after 3 months get extra …

This study looks at whether using a mindfulness app on a smartphone for 8 weeks can improve mental health in Korean immigrants aged 60 and older. Participants use the app for about 10-15 minutes daily and have weekly check-ins. The goal is to see if the app is easy to use and hel…

This study tests whether watching short videos with mindfulness exercises (like guided meditation or expressive writing) before and after abdominal cancer surgery can help manage pain and distress. About 95 adults will be assigned to mindfulness videos, standard hospital resource…

This study tests whether a 12-week supervised group exercise program with music can boost emotional well-being in physically inactive women aged 35-60 who feel stressed or down. One hundred women will be randomly assigned to either the exercise group or a waitlist. Researchers wi…

This study tests whether a 5-week heart rate variability biofeedback program can lower stress and anxiety in 50 dentistry students moving from classroom to clinic. Participants in the training group practice slow breathing with real-time feedback, while a control group receives n…

This study tests whether trained LGBTIQA+ community members can provide effective counseling to reduce psychological distress and violence exposure. About 960 LGBTIQA+ adults in Nepal will receive either individual counseling, counseling plus group sessions, or standard care. The…

This study looks at whether a group stress management program called Self-Help Plus (SH+) can improve the mental health of refugee mothers and their preschool children in Uganda. About 725 mothers and their children will take part, with some villages getting the program and other…

This study tests whether a program called Bright IDEAS can help parents of children receiving palliative care feel less anxious, depressed, and stressed. The program teaches parents a step-by-step approach to solving problems. Forty parents will take part in 6-8 sessions and repo…

This study tests whether a World Health Organization program called Self-Help Plus (SH+) can help reduce stress in social service workers. About 50 workers from four institutions in Istanbul will be randomly assigned to either receive SH+ plus usual support, or usual support alon…

This study is observing how people change during psychological therapy at a clinic in Quito, Ecuador. About 340 patients aged 11 and older will fill out short questionnaires before and after sessions to track their distress and well-being. The goal is to learn how routine monitor…