PROSTATIC NEOPLASMS

This early-phase study tested the safety and how the body processes the drug MK-5684 in 14 Chinese men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goal was to check for side effects and measure drug levels in the blood. Th…

This study looked at whether men with advanced prostate cancer could safely stop their regular hormone injections (like leuprolide) and just take abiraterone and prednisone pills instead. The goal was to see if testosterone levels stayed low enough without the shots. 31 men parti…

This early-phase study tested a new drug called CC-94676 in 131 men with advanced prostate cancer that had spread and stopped responding to standard hormone treatments. The main goals were to check the drug's safety, find the right dose, and see if it could help control the cance…

This study tested whether adding the drug darolutamide to standard hormone therapy (ADT) helps men with prostate cancer that has spread to other parts of the body. 669 men participated. The goal was to see if the combination could delay cancer growth and improve survival. Results…

This early-stage study tested the safety of a new drug called opevesostat (MK-5684) in 7 Japanese men with a type of advanced prostate cancer that no longer responds to standard hormone therapy and chemotherapy. The goal was to see if the drug is safe and how it works in the body…

This study tested whether adding apalutamide to standard hormone therapy after prostate removal surgery could delay cancer recurrence in 108 high-risk patients. The main goal was to see how many men had no sign of cancer (measured by PSA levels) after 24 months. Results suggest t…

This early-phase study tested the safety of combining two drugs, abemaciclib and darolutamide, in 10 men with advanced prostate cancer that had spread and stopped responding to standard hormone therapy. The main goal was to see if the combination was safe and tolerable. Participa…

This early-phase study tested a new treatment called JNJ-75229414, which uses a patient's own immune cells (CAR-T cells) to target a protein found on prostate cancer cells. The study involved 15 men with metastatic castration-resistant prostate cancer who had already tried other …

This study tested a drug called niraparib in 289 men with a hard-to-treat type of prostate cancer that has spread and has specific DNA repair issues. The goal was to see if the drug could shrink tumors or slow the cancer's growth. Participants had already tried other treatments l…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to targeted radiation could help control prostate cancer that has spread to a few places in the body. Twenty-three men with newly diagnosed, hormone-sensitive prostate cancer took part. The goal was …

This study tested whether two advanced imaging techniques—high-resolution MRI and a special PET-MRI scan—can find prostate cancers that standard MRI might miss. 62 men who were considering focal HIFU therapy or prostate removal took part. The goal was to see if these newer scans …

This study tested a new imaging agent called [18F]CTT1057 for PET scans to find prostate cancer that has come back after initial treatment. About 190 men with rising PSA levels (a sign of possible recurrence) took part. The goal was to see how accurately the scan could locate can…

This study tested a simple, rapid PSA test that uses whole blood to see if it works as well as the standard lab test for prostate cancer screening. Researchers compared results from 94 patients with prostate cancer or benign prostate disease. The goal was to see if the quick test…

This study tested an artificial intelligence (AI) model designed to detect whether prostate cancer has spread to lymph nodes. Researchers compared the AI's accuracy to standard pathology reports from 225 patients who had their prostate and nearby lymph nodes removed. The goal was…

This study tested a new PET imaging agent called [18F]CTT1057 to see how well it can find prostate cancer tumors. 195 high-risk patients who were scheduled for surgery received the scan, and the results were compared to tissue samples taken during surgery. The goal was to see if …

This study tested a remote monitoring system called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Participants used the system (with or without home nursing) or received standard care. The goal was to see if the system improved phy…

This pilot study tested a program called PROWESS that uses fitness trackers and coaching to help Black and Hispanic men with prostate cancer exercise more while on hormone therapy. The goal was to reduce treatment side effects and improve quality of life. Fourteen men participate…

This study looked at the total cost of care over 5 years for men with localized prostate cancer who had either robot-assisted surgery or open surgery. Researchers tracked all medical expenses from the surgery itself to follow-up care. The goal was to see which approach is more co…

This study looked at how prostate cancer patients feel about their quality of life three years after diagnosis, when they are expected to be back to normal. Researchers compared 900 patients to people of the same age without cancer. The goal was to understand the long-term impact…

This study followed nearly 1,000 Japanese men with high-risk metastatic prostate cancer that had not yet been treated with hormone therapy. Researchers tracked how well standard treatments worked in everyday medical practice, including effects on PSA levels, cancer progression, s…

This study looked at genetic changes in prostate cancer tissue from 84 men who had their prostate removed. The goal was to find DNA markers that could predict if the cancer would come back or spread. By identifying these markers, doctors may one day better tailor follow-up care a…

This study looked at insurance records of over 3,000 men aged 65 and older with metastatic prostate cancer that still responds to hormone therapy. Researchers wanted to see how long patients actually take newer hormonal drugs (abiraterone, apalutamide, or enzalutamide) in everyda…

This study looked at 50 men having prostate surgery to see if the special positions used in robotic surgery increase pressure on the breathing tube and cause more throat pain, hoarseness, or trouble swallowing afterward. The researchers measured tube pressure during surgery and c…

This study looked at oxygen levels inside prostate tumors in 186 men with early-stage prostate cancer. Researchers used a special needle to measure oxygen before starting radiotherapy or hormone therapy. The goal was to see if low oxygen (hypoxia) makes treatment less effective o…