PROSTATIC NEOPLASMS

This small, early-stage study tested the safety of combining two drugs, abemaciclib and darolutamide, in men with advanced prostate cancer that had spread and stopped responding to standard hormone therapy. The main goal was to see if the combination was safe and tolerable for pa…

This early-stage study tested a new drug called CC-94676 in men with advanced prostate cancer that had spread and was no longer responding to standard hormone therapies. The main goal was to find a safe dose and understand how the drug behaves in the body. Researchers also looked…

This study tested whether the drug niraparib could help control advanced prostate cancer that had stopped responding to standard hormone therapies and had spread. It specifically enrolled 289 men whose cancer had specific problems with DNA repair, a genetic weakness the drug is d…

This study tested whether men with advanced prostate cancer who take abiraterone and prednisone pills could safely stop their regular hormone injections. Researchers wanted to see if testosterone levels would stay low enough to control the cancer without the injections. The trial…

This study tested a combination treatment for men newly diagnosed with prostate cancer that had spread to a few other sites in the body. The goal was to see if adding an immunotherapy drug (pembrolizumab), with or without an immune-boosting injection (SD-101), to standard radiati…

This study tested whether adding a new drug called darolutamide to standard hormone therapy helps men whose prostate cancer has spread. It involved 669 men and compared the combination to hormone therapy alone. The main goal was to see if the new combination could delay the cance…

This early-stage study tested a new oral drug called MK-5684 (opevesostat) in 14 Chinese men with advanced prostate cancer that had spread and stopped responding to standard hormone treatments. The main goals were to check the drug's safety, see how well it was tolerated, and mea…

This study tested a new artificial intelligence (AI) tool designed to help pathologists find prostate cancer that has spread to lymph nodes. Researchers compared the AI's accuracy against standard lab reports from 225 patients who had surgery. The goal is to see if the AI can mak…

This study tested a new type of PET scan designed to find and pinpoint prostate cancer tumors more accurately. It involved 195 men with newly diagnosed, high-risk prostate cancer who were scheduled for surgery. Researchers compared the scan results directly to tissue samples from…

This study tested a new, faster way to check PSA levels, a marker for prostate health. Researchers compared a simple test strip that uses a few drops of blood to the standard, more complex lab test. They wanted to see if the quick test was as accurate for monitoring patients with…

This study tested if two new, advanced imaging scans could find prostate cancers that a standard MRI scan might miss in patients planning for a targeted therapy or surgery. The goal was to create a more accurate 'map' of the cancer to help guide treatment decisions. Researchers c…

This study tested a new type of PET scan, using a tracer called [18F]CTT1057, to see how well it could find and locate returning prostate cancer in men whose PSA levels were rising after initial surgery or radiation. About 190 men participated, each receiving the new scan and a s…

This small pilot study tested a supportive care program combining wearable fitness trackers with coaching to help Black and Hispanic men with prostate cancer increase exercise and manage treatment side effects. The program aimed to improve quality of life for patients undergoing …

This study tested whether a remote monitoring app could improve quality of life for people with advanced cancer. It involved 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Researchers compared patients using the app to report symptoms from home against p…

This study created a registry to observe the real-world outcomes of 979 Japanese men with advanced, high-risk prostate cancer that had already spread. It tracked how well standard hormone-based treatments worked over time by measuring cancer progression, survival, and patients' q…

This study observed 50 men having prostate surgery to see if the special positioning used in robotic surgery increases pressure in the breathing tube. Researchers monitored this pressure during surgery and checked patients for sore throat, hoarseness, and swallowing problems afte…

This study compared the total 5-year healthcare costs and patient outcomes between two prostate cancer surgery methods: robotic-assisted surgery and traditional open surgery. Researchers followed 90 patients with localized prostate cancer to track expenses, recovery, side effects…

This study looked at how long men 65 and older with advanced prostate cancer that responds to hormone therapy stayed on newer hormone treatments. Researchers analyzed Medicare insurance claims data from over 3,000 men who were prescribed these medications by their regular doctors…

This study aimed to understand how prostate cancer affects men's quality of life three years after diagnosis, when they're expected to have returned to normal life. Researchers compared 900 men with prostate cancer to similar men without cancer, all living in the same region of F…

This study investigated whether low oxygen levels in prostate tumors make them harder to treat. Researchers measured oxygen in tumors of 186 men before they started radiation therapy. The goal was to see if low oxygen predicts whether cancer will spread or become resistant to hor…