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New drug combo shows promise in early prostate cancer trial

NCT ID NCT05999968

First seen Mar 06, 2026 · Last updated Apr 29, 2026 · Updated 7 times

Summary

This early-phase study tested the safety of combining two drugs, abemaciclib and darolutamide, in 10 men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The goal was to see if the combination is safe enough to study further. Participants were followed for up to 32 months to monitor side effects and how long the cancer stayed under control.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Highlands Oncology Group

    Springdale, Arkansas, 72762, United States

  • Hospital General Universitario Gregorio Marañon

    Madrid, Madrid, Comunidad de, 28009, Spain

  • Hospital Infanta Cristina

    Badajoz, 06006, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, Comunidad de, 28041, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • Instituto Catalan de Oncologia - Hospital Duran i Reynals

    L'Hospitalet de Llobregat, Catalunya [Cataluña], 8907, Spain

  • Klinikum Rechts Der Isar Der Technischen Universität München

    Munich, Bavaria, 81675, Germany

  • Laura and Isaac Perlmutter Cancer Center

    New York, New York, 10016, United States

  • Perlmutter Cancer Center at NYU Langone Hospital - Long Island

    Mineola, New York, 11501, United States

  • Studienpraxis Urologie

    Nürtingen, Baden-Wurttemberg, 72622, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitätsklinikum Schleswig-Holstein

    Lübeck, Schleswig-Holstein, 23538, Germany

Conditions

Explore the condition pages connected to this study.