POSTOPERATIVE DELIRIUM

This study tests whether electroacupuncture, a type of acupuncture with mild electrical pulses, can prevent postoperative delirium (sudden confusion) in older adults having total knee replacement. About 1,460 participants aged 65-90 will receive either electroacupuncture or a sha…

This study looks at whether giving ibuprofen during and after lung surgery can help keep the brain well-oxygenated and reduce confusion or memory loss afterward. About 54 adults having keyhole lung surgery with one-lung ventilation will be randomly assigned to receive ibuprofen o…

This study tests whether giving elderly patients a paracetamol injection after non-cardiac surgery can lower their risk of postoperative delirium (sudden confusion). About 1,092 people aged 60 and older in the ICU will receive either paracetamol or a standard opioid painkiller. T…

This study tests whether taking creatine, a supplement often used for muscle strength, can help protect the brain in older adults having surgery. Surgery can sometimes cause confusion or memory problems, especially in older people. Researchers will give creatine to 80 adults sche…

This study tests whether a low dose of esketamine, a common anesthetic, can prevent confusion and memory problems in older adults after non-cardiac surgery. About 120 patients aged 65-90 will receive one of three esketamine doses or a placebo during and after surgery. The goal is…

This study tests whether a sedative called remimazolam can lower the chance of confusion (delirium) after stomach cancer surgery in people aged 65 and older. Half of the 170 participants will get remimazolam, the other half standard sedatives. The goal is to see if remimazolam le…

This study tests whether giving flumazenil after hip replacement surgery can prevent confusion and memory problems. 150 adults having hip surgery under spinal anesthesia will receive either flumazenil or a placebo. Researchers will check thinking skills and delirium rates in the …

This study looks at 400 older adults (65+) having planned hip replacement surgery in the Czech Republic. Researchers want to see if a short memory test given before surgery can predict who might become confused or delirious afterward. The goal is to make routine memory checks sta…

This study looks at whether using an EEG (a brain-wave monitor) during surgery to guide pain medication can lower the risk of delirium—sudden confusion—after the operation. Researchers will enroll 600 adults aged 60 and older who are having non-emergency surgery. The goal is to s…

This study looks at whether a blood sugar measurement taken before surgery can help predict if a patient will develop delirium—a state of confusion—after their operation. Researchers will analyze data from 15,000 adults who had non-brain, non-heart surgeries. The goal is to find …

This study looks at whether measuring the optic nerve sheath (the covering of the nerve at the back of the eye) using ultrasound can help predict delirium—sudden confusion or agitation—after heart surgery. Delirium is common in older adults after surgery and can lead to longer ho…

This study looks at whether measuring how the brain uses sugar (glucose) before surgery can help predict if older adults with type 2 diabetes will become confused or delirious after their operation. Researchers will scan the brains of 154 people aged 65 and older before liver tum…

This study will measure certain brain chemicals in 200 children, ages 1 to 3, before, during, and after hernia surgery. The goal is to see if changes in these chemicals can predict which children might experience confusion or long-term learning problems. Researchers will also com…

This study looks at whether a simple test called the MO-FA2-(TB) score can predict which patients will become confused (delirium) after planned heart surgery. About 100 adults having heart valve or bypass surgery will be checked before and after their operation. The goal is to be…

This study looks at whether the way you sleep before heart surgery is connected to your risk of confusion (delirium) and kidney injury after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to better understand t…